Inhibitory Avoidance
Mostrando 1-12 de 74 artigos, teses e dissertações.
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1. Hypericum perforatum chronic treatment affects cognitive parameters and brain neurotrophic factor levels
Objective: To evaluate the effects of Hypericum perforatum (hypericum) on cognitive behavior and neurotrophic factor levels in the brain of male and female rats. Methods: Male and female Wistar rats were treated with hypericum or water during 28 days by gavage. The animals were then subjected to the open-field test, novel object recognition and step-down i
Rev. Bras. Psiquiatr.. Publicado em: 09/08/2018
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2. Behavioral alterations induced by repeated saxitoxin exposure in drinking water
Abstract Background Blooms of the saxitoxin-producing cyanobacterium Cylindrospermopsis raciborskii have been contaminating drinking water reservoirs in Brazil for many years. Although acute effects of saxitoxin intoxication are well known, chronic deleterious outcomes caused by repeated saxitoxin exposure still require further investigation. The aim of th
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 14/06/2016
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3. Environmental enrichment restores cognitive deficits induced by experimental childhood meningitis
Objective: To evaluate the influence of environmental enrichment (EE) on memory, cytokines, and brain-derived neurotrophic factor (BDNF) in the brain of adult rats subjected to experimental pneumococcal meningitis during infancy. Methods: On postnatal day 11, the animals received either artificial cerebrospinal fluid (CSF) or Streptococcus pneumoniae suspen
Rev. Bras. Psiquiatr.. Publicado em: 25/07/2014
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4. Evaluation of neurotransmitters involved in the anxiolytic and panicolytic effect of the aqueous fraction of Paullinia cupana (guaraná) in elevated T maze
This study investigated the effects of repeatedly administration of an aqueous fraction of Paullinia cupana Kunth, Sapindaceae (guaraná) seeds (8 mg/kg) on rats submitted to the elevated T-maze, model of generalized anxiety and panic disorders. The selective serotonin reuptake inhibitor paroxetine (3 mg/kg), was used as a positive control. To evaluate possi
Rev. bras. farmacogn.. Publicado em: 05/03/2013
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5. Avaliação da memória emocional em camundongos : efeito da injeção de midazolam na substância cinzenta periaquedutal
Varios estudos tem demonstrado que os benzodiazepinicos (BDZ), administrados na substancia cinzenta periaquedutal (SCP), podem produzir efeito ansiolitico em diferentes modelos animais de ansiedade e tambem prejudicar a aprendizagem e a memoria em roedores. Apesar do ja conhecido papel da SCP em modular comportamentos defensivos em modelos animais, pouco se
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/12/2012
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6. Um estudo sobre a interação dos sistemas colinérgico nicotínico e dopaminérgico na persistência de memórias aversivas
Long-term memory (LTM) storage requires activation of the ventral tegmental area (VTA)- hippocampus dopaminergic loop and synthesis of brain-derived neurotrophic factor (BDNF) late after learning (Bekinschtein et al., 2007; Rossato et al., 2009). Nicotinic acetylcholine receptors (nAChR) modulate VTA function. Therefore, we analyzed the involvement of these
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2012
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7. Dorsal periaqueductal gray stimulation facilitates anxiety-, but not panic-related, defensive responses in rats tested in the elevated T-maze
The escape response to electrical or chemical stimulation of the dorsal periaqueductal gray matter (DPAG) has been associated with panic attacks. In order to explore the validity of the DPAG stimulation model for the study of panic disorder, we determined if the aversive consequences of the electrical or chemical stimulation of this midbrain area can be dete
Braz J Med Biol Res. Publicado em: 2012-11
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8. Anxiolytic effects of repeated treatment with an essential oil from Lippia alba and (R)-(-)-carvone in the elevated T-maze
Lippia alba (Mill.) N.E. Brown (Verbenaceae) is widely used in different regions of Central and South America as a tranquilizer. The plant’s anxiolytic properties, however, merit investigation. The present study evaluated the effects of repeated daily (14 days) intraperitoneal (ip) treatment with an essential oil (EO) from a chemotype of L. alba (LA, chemo
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
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9. Cafeína reverte prejuízo da memória decorrente da idade com modificações no fator neurotrófico derivado do encéfalo
The beneficial effects of chronic caffeine administration in memory performance have been observed in different conditions and animal models but the underlying mechanisms remain unknown. This study was designed to investigate whether chronic caffeine administration could improve the performance in different memory tasks used in adult and middle-aged rats. In
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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10. O impacto da frequência do exercício físico sobre proteínas sinápticas e o comportamento de ratos durante a fase adulta e no envelhecimento
Physical exercise is considered an important alternative in reducing the risk of many diseases and improves the quality of life. These benefits are most evident when the body becomes more vulnerable, either through the natural process of aging or in the onset of neurodegenerative disease. However, the amount of exercise for these benefits is unkwon. Thus, th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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11. A participação de diferentes sistemas neuromodulatórios no hipocampo, núcleo basolateral da amígdala e córtex pré-frontal ventromedial na extinção de memórias aversivas
Extinction consists of the learned inhibition of retrieval of previously acquired memory. Many forms of learning are modulated by ¿-noradrenergic, D1-dopaminergic and H2-histaminergic receptors on ventromedial prefrontal cortex (vmPFC), basolateral amygdala (BLA) and dorsal hippocampus. Therefore, the aim of this work was investigated the modulation of aver
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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12. Efeito do Butirato de sódio sobre o déficit de memória induzido pela sobrecarga neonatal com ferro
Iron accumulation in the brain has been associated to the pathogenesis of neurodegenerative disorders. We have previously demonstrated that iron overload in the neonatal period results in severe and persistent memory deficits in adult rats. Here, using the animal model of cognitive impairment induced by iron overload we tested the effects of NaBut in amelior
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/03/2011