Inorganic Drugs
Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. METHODS FOR EXTRACTION AND ISOLATION OF AGATHISFLAVONE FROM POINCIANELLA PYRAMIDALIS
Agathisflavone is a natural biflavone with restricted occurrence in plants. This biflavone presents several biological activities and can be important to developing new drugs. Obtaining such a molecule on a large scale for in vivo tests is a challenge. To date, there are no reports regarding its synthesis; thus, it is important to improve and develop methods
Química Nova. Publicado em: 2022
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2. Study of Inorganic Profiles of Street Cocaine Samples Using ICP-MS and ICP OES
Determining inorganic constituents in illicit drugs can indicate its purity and presence of adulterants. In this study, we analyzed 52 street cocaine samples, seized in three different regions of Espírito Santo, state of Brazil. Inductively coupled plasma optical emission spectrometry was used to determine Al, Ca, Cu, Fe, Mn, Mg, Zn concentrations and induc
J. Braz. Chem. Soc.. Publicado em: 2021-01
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3. Hidróxidos duplos lamelares: nanopartículas inorgânicas para armazenamento e liberação de espécies de interesse biológico e terapêutico
Studies about the inorganic nanoparticles applying for non-viral release of biological and therapeutic species have been intensified nowadays. This work reviews the preparation strategies and application of layered double hydroxides (LDH) as carriers for storing, carrying and control delivery of intercalated species as drugs and DNA for gene therapy. LDH sho
Química Nova. Publicado em: 2010
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4. Estudo do potencial genotóxico, citotóxico e antitumoral do composto Cloreto de cis-tetraaminodiclororutênio(III) sobre diferentes células tumorais / To study the potential genotoxic, cytotoxic and antitumor compound Chloride, cis-tetraaminodiclororutênio (III) on various tumor cells
Current inorganic drugs such cisplatin and related compounds widely used in the treatment cancer, however its application is limited by its severe toxicity and drug resistence. These limitations have prompted a search for news metal-based antitumor agents. Ruthenium (III) complexes represent a new family of promising metal-based anticancer drugs. In the pres
Publicado em: 2010
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5. Intercalação de fármacos com atividade antiinflamatória (ácido mefenâmico e piroxicam) em hidróxido duplo lamelar / Intercalation of drugs with antiinflammatory activity (mefenamic acid and piroxicam) in layered double hydroxide
A intercalação de espécies de interesse biológico e terapêutico em Hidróxidos Duplos Lamelares (HDLs) vem se mostrando uma estratégia interessante para a obtenção de sistemas de armazenamento ou carregadores de drogas. No presente trabalho foram investigadas rotas sintéticas e parâmetros experimentais para a intercalação dos ânions derivados do
Publicado em: 2007
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6. SYNTHESIS AND CHARACTERIZATION OF MAGNETIC COBALT FERRITE NANOPARTICLES COVERED WITH 3-AMINEPROPYLTRIETHOXYSILANE FOR USE AS HYBRID MATERIAL IN NANOTECHNOLOGY / "Síntese e caracterização de nanopartículas magnéticas de ferrita de cobalto recobertas por 3-aminopropiltrietoxissilano para uso como material híbrido em nanotecnologia"
Nowadays with the appear of nanoscience and nanotechnology, magnetic nanoparticles have been finding a variety of applications in the fields of biomedicine, diagnosis, molecular biology, biochemistry, catalysis, etc. The magnetic functionalized nanoparticles are constituted of a magnetic nucleus, involved by a polymeric layer with active sites, which ones co
Publicado em: 2006
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7. Talinum patens: Análise por ativação neutrônica instrumental e prospecção fitoquímica
The use of plants for many diseases treatment is a millenary knowledge. These are the great importance for the formation of actual medicine bases. Actually, more than 25 % of the all drugs prescribed in the world are obtained from plants. The medicinal plants and other vegetable materials market reach to around two billions dollars. The researches of natural
Publicado em: 2005
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8. Planejamento racional de drogas contra tripanosomatídeos: gGAPDH de Trypanosoma cruzi e XPRT de Leishmania major / Rational design of anti-trypanosomatids drugs: T. cruzi gGAPDH and Leishmania major XPRT
Aiming at discover molecules with good inhibitory activity against tripanosomatides enzymatic targets, the crystallographic structures of glyceraldehydes-3-phosphate dehydrogenase in complex with 1,3 bisfosfoglyceric acid analogues (30 and 33)were solved, molecular modeling studies were undertaken and xprt (xanthine phosphorybosil transferase) gene from Leis
Publicado em: 2004
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9. Síntese, caracterização e atividade catalítica de novos catalisadores metaloporfirínicos suportados / Synthesis, characterization and catalytic activity of novel anchored metalloporphyrin catalysts
In this work the second generation metalloporphyrin Me(TFPP)Cl (Me = Fe and Mn) [5,10, 15, 20 ? tetrakis(pentafluorophenyl) porphyrin iron (III) or manganese (III) chloride] was covalently anchored to aminofunctionalyzed supports, through nucleophilic substituition of the para-fluorine atoms of the pentafluorophenyl meso-aryl groups, with the objective of ob
Publicado em: 2004
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10. Interaction of rhodium(II) complexes with human serum albumin / Interações de Complexos de Ródio(II) com Albumina Humana
Vários complexos de ródio Rh2(L)4 (L = acetato, propionato, butirato, trifluoroaceta-to e trifluoroacetamidato) ligam-se à albumina de soro humana (HSA) em relações mola-res de aproximadamente 8:1. Medidas de dicroísmo circular mostraram que os carboxila-tos mais lipossolúveis (butirato e trifluoroacetato) provocaram as maiores alterações na estrutu
Publicado em: 2000
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11. Polyphosphate kinase is essential for biofilm development, quorum sensing, and virulence of Pseudomonas aeruginosa
The human opportunistic pathogen Pseudomonas aeruginosa causes a variety of infections in immunocompromised hosts and in individuals with cystic fibrosis. A knockout mutation in the polyphosphate kinase (ppk) gene, encoding PPK responsible for the synthesis of inorganic polyphosphate from ATP, renders P. aeruginosa cells unable to form a thick and differenti
The National Academy of Sciences.
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12. [3H]nitrendipine-labeled calcium channels discriminate inorganic calcium agonists and antagonists.
[3H]Nitrendipine binds with high affinity to brain membranes with a drug specificity indicating association with sites mediating the pharmacologic actions of dihydropyridine slow-calcium-channel antagonist drugs. In brain membranes, [3H]nitrendipine binding is absolutely dependent on the presence of calcium ions. Interactions of cation with [3H]nitrendipine