Inotropic Activity
Mostrando 1-12 de 62 artigos, teses e dissertações.
-
1. The role of oxytocin in cardiovascular regulation
Studies of body volume expansion have indicated that lesions of the anteroventral third ventricle and median eminence block the release of atrial natriuretic peptide (ANP) into the circulation. Detailed analysis of the lesions showed that activation of oxytocin (OT)-ergic neurons is responsible for ANP release, and it has become clear that activation of neur
Braz J Med Biol Res. Publicado em: 18/03/2014
-
2. Acute exposure to lead increases myocardial contractility independent of hypertension development
We studied the effects of the acute administration of small doses of lead over time on hemodynamic parameters in anesthetized rats to determine if myocardial contractility changes are dependent or not on the development of hypertension. Male Wistar rats received 320 µg/kg lead acetateiv once, and their hemodynamic parameters were measured for 2 h. Cardiac c
Braz J Med Biol Res. Publicado em: 01/02/2013
-
3. EFFECT OF AQUEOUS FRACTION OF LEAVES DE COSTUS SPIRALIS (JACQ.) ROSCOE CONTRACTILE FUNCTION ON HEART MAMMALS. / EFEITO DA FRAÇÃO AQUOSA DAS FOLHAS DE COSTUS SPIRALIS (JACQ.) ROSCOE SOBRE A FUNÇÃO CONTRÁTIL DO CORAÇÃO DE MAMÍFEROS.
Teas and infusions from C. spiralis leaf have largely been used by folk medicine as diuretic, hypotensor, cytotoxic, immunomodulator, antilithiasic, antidiarrheic, antispasmodic, antiurolitic, antimicrobian, antifungic, antioxidant, antileishmania activity, antiinflamatory, and antiedematogenic activity. In spite of these biological effects attributed to the
Publicado em: 2011
-
4. Ventricular performance and Na+-K+ ATPase activity are reduced early and late after myocardial infarction in rats
Myocardial infarction leads to compensatory ventricular remodeling. Disturbances in myocardial contractility depend on the active transport of Ca2+ and Na+, which are regulated by Na+-K+ ATPase. Inappropriate regulation of Na+-K+ ATPase activity leads to excessive loss of K+ and gain of Na+ by the cell. We determined the participation of Na+-K+ ATPase in ven
Brazilian Journal of Medical and Biological Research. Publicado em: 04/09/2009
-
5. Lead reduces tension development and the myosin ATPase activity of the rat right ventricular myocardium
Lead (Pb2+) poisoning causes hypertension, but little is known regarding its acute effects on cardiac contractility. To evaluate these effects, force was measured in right ventricular strips that were contracting isometrically in 45 male Wistar rats (250-300 g) before and after the addition of increasing concentrations of lead acetate (3, 7, 10, 30, 70, 100,
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-09
-
6. Resposta inotropica a catecolaminas em miocitos ventriculares isolados de ratos submetidos a choque nas patas / Inotropic esponsiveness to catecholamines in ventricular myocytes isolated from footshock-stressed rats
Supersensitivity to isoproterenol (ISO) chronotropic effect has been described in right atria from footshock-stressed rats, but information on inotropic responsiveness, particularly of the ventricles, is scarce. The goal of this study was to analyze the inotropic and pro-arrhythmic effect of catecholamines on left ventricular myocytes from footshockstressed
Publicado em: 2007
-
7. Influência do ácido orótico no metabolismo energético cardíaco de ratos
The functional cardiac performance is closely related to energetic metabolism. Studies have shown that the disarrangements usually associated to ischemia and reperfusion, such as ionic imbalance and impairment of contratiles proteins, are consequence of installed metabolic changes, associated with a reduction of ATP levels. Several experimental and clinical
Publicado em: 2007
-
8. Eucalyptol, an essential oil, reduces contractile activity in rat cardiac muscle
Eucalyptol is an essential oil that relaxes bronchial and vascular smooth muscle although its direct actions on isolated myocardium have not been reported. We investigated a putative negative inotropic effect of the oil on left ventricular papillary muscles from male Wistar rats weighing 250 to 300 g, as well as its effects on isometric force, rate of force
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-03
-
9. Cardiac and vascular effects of diltiazem, dobutamine and amrinone, drugs used after myocardial revascularization
Hemodynamic care during postoperative management of myocardial revascularization should include vasorelaxing drugs to insure adequate graft and coronary flow, and stimulation of stroke volume to maintain vascular perfusion pressure. We tested the cardiac (inotropic and lusitropic) and vascular (relaxant) effects of diltiazem (0.1 nM to 0.1 mM), dobutamine (1
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-06
-
10. Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium
Many pharmacological effects have been ascribed to extracts of Psidium guajava L. (guava) leaves. However, in spite of its widespread use in Brazilian folk medicine and a reasonable number of scientific reports about it, we could not find any study dealing with its action on the mammalian myocardium. In the present study, by measuring isometric force, we obs
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-05
-
11. Impaired beta-adrenergic response and decreased L-type calcium current of hypertrophied left ventricular myocytes in postinfarction heart failure
Infarct-induced heart failure is usually associated with cardiac hypertrophy and decreased ß-adrenergic responsiveness. However, conflicting results have been reported concerning the density of L-type calcium current (I Ca(L)), and the mechanisms underlying the decreased ß-adrenergic inotropic response. We determined I Ca(L) density, cytoplasmic calcium ([
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-05
-
12. Cardiovascular effects induced by the aqueous fraction of the ethanol extract of the stem of Solanum stipulaceum in rats
The cardiovascular effects induced by the aqueous fraction of the ethanol extract of the stem (AFS) of Solanum stipulaceum Roem. & Schult were studied in rats. In non-anesthetized rats, AFS injections produced significant and dosedependent hypotension associated with increase in heart rate. In isolated rat superior mesenteric rings, AFS was able to antagoniz
Revista Brasileira de Farmacognosia. Publicado em: 2002