Intracellular Persistence
Mostrando 1-12 de 101 artigos, teses e dissertações.
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1. Deciphering the contribution of lipid droplets in leprosy: multifunctional organelles with roles in Mycobacterium leprae pathogenesis
Leprosy is an infectious disease caused by Mycobacterium leprae that affects the skin and nerves, presenting a singular clinical picture. Across the leprosy spectrum, lepromatous leprosy (LL) exhibits a classical hallmark: the presence of a collection of M. leprae-infected foamy macrophages/Schwann cells characterised by their high lipid content. The signifi
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
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2. Avaliação das populações de linfócitos produtores de IFN-g e IL-17 em pacientes sépticos e relação com o desfecho clínico. / Evaluation of lymphocyte populations producing IFN-g and IL-17 in septic patients and relation to clinical outcome.
The inflammatory response is modulated during sepsis and up or down regulation of cell activity depends on cells and functions evaluated. IFN-g and IL-17 are cytokines characteristics of lymphocyte subsets Th1 and Th17, respectively, and play an important role in immune response, linking innate and adaptative immunity. Objective: To evaluate the presence of
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/07/2010
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3. Aderência, invasão e persistência intracelular de estreptococos do grupo B em células epiteliais respiratórias A549 / Adhesion, invasion and intracellular persistence of group B Streptococci in respiratory epithelial cells A549
Estreptococos do grupo B (EGB) comumente colonizam adultos saudáveis, sem sintomas, mas sob certas circunstâncias possui a capacidade de invadir tecidos do hospedeiro, evadir da detecção imunológica e causar doenças invasivas graves. Por conseguinte, os EGB continuam sendo uma das principais causas de mortalidade neonatal, pneumonia, sepse e meningite.
Publicado em: 2010
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4. Avaliação do estresse oxidativo sob a resposta imune de bovinos infectados pelo vírus da leucose enzoótica bovina / Evaluation of oxidative stress on the immune response of bovine leukemia virus-infected dairy cows
Abundant observations of multiple pathogenic interactions between reactive oxygen species (ROS) and the pathogenesis of some retroviruses have drawn attention to role of ROS on disease progression and/or persistence of infection. Therefore, the role of the oxidative stress resulted from the modulation of the antioxidant system in dairy cows naturally infecte
Publicado em: 2010
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5. Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection
Proline racemase is an important enzyme of Trypanosoma cruzi and has been shown to be an effective mitogen for B cells, thus contributing to the parasite's immune evasion and persistence in the human host. Recombinant epimastigote parasites overexpressing TcPRAC genes coding for proline racemase present an augmented ability to differentiate into metacyclic i
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-12
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6. Swimming against the current: genetic vaccination against Trypanosoma cruzi infection in mice
Vaccines have had an unquestionable impact on public health during the last century. The most likely reason for the success of vaccines is the robust protective properties of specific antibodies. However, antibodies exert a strong selective pressure and many microorganisms, such as the obligatory intracellular parasite Trypanosoma cruzi, have been selected t
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07
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7. Development and evaluation of residual virulence of a mutant strain of Brucella Abortus / Desenvolvimento e avaliação da virulência residual de uma cepa mutante de Brucella abortus
Brucella spp. is an intracellular facultative gram-negative bacteria which is pathogenic for many species of mammals, causing brucelosis, a worldwide spread zoonosis. Therefore the search for more efficient alternatives of control, as the development of new strains that can be tested as potential immunogens, is necessary. In this study, we knockouted virB10
Publicado em: 2009
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8. Mycobacteriosis in the compromised host
The studies of rare genetic defects, the preliminary results of population-based studies, being validated by the experimental immunocompromised animal models and the current observations accumulated in immunocompromised patients with mycobacterial diseases provide us with insights into the importance of the macrophage activation pathway in controlling human
Memórias do Instituto Oswaldo Cruz. Publicado em: 2000
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9. Utilidade da pesquisa de anticorpos IgA anti-toxoplasma gondii para o diagnostico sorologico da toxoplasmose aguda adquirida
Toxoplasmosis, an infection caused by the intracellular parasite Toxoplasma gondii, is generally asymptomatic or is associated with mild, nonspecific clinical manifestations in immunocompetent subjects. The detection of Toxoplasma-specific antibodies has been considered the most valuable tool for diagnosing toxoplasmosis. Serological diagnosis of acute toxop
Publicado em: 1996
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10. Bioluminescence as a Reporter of Intracellular Survival of Bordetella bronchiseptica in Murine Phagocytes
The uptake and persistence of Bordetella bronchiseptica was characterized in murine phagocytes by using a novel bioluminescence-based reporter system. A mini-Tn5 promoter probe carrying the intact lux operon from the terrestrial bacterium Photorhabdus luminescens which allowed measurement of light output without the addition of exogenous substrate was constr
American Society for Microbiology.
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11. Intracellular Tryptophan Pool Sizes May Account for Differences in Gamma Interferon-Mediated Inhibition and Persistence of Chlamydial Growth in Polarized and Nonpolarized Cells
Gamma interferon (IFN-γ) is an important factor in the modulating inhibition of intracellular chlamydial growth and persistence. In human epithelial cells and macrophages, this inhibition is the result of depletion of the essential amino acid tryptophan via the IFN-γ-induced enzyme indoleamine 2,3-dioxygenase. Under these conditions, chlamydiae must succes
American Society for Microbiology.
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12. Selection of Small-Colony Variants of Salmonella enterica Serovar Typhimurium in Nonphagocytic Eucaryotic Cells
Salmonella enterica strains are enteropathogenic bacteria that survive and proliferate within vacuolar compartments of epithelial and phagocytic cells. Recently, it has been reported that fibroblast cells are capable of restricting S. enterica serovar Typhimurium intracellular growth. Here, we show that prolonged residence of bacteria in the intracellular en
American Society for Microbiology.