Intracellular Transport
Mostrando 1-12 de 1738 artigos, teses e dissertações.
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1. Expression of myo-inositol cotransporters in the sciatic nerve and dorsal root ganglia in experimental diabetes
The transport of myo-inositol is the main mechanism for the maintenance of its high intracellular levels. We aimed to measure the mRNA and protein levels of myo-inositol cotransporters in the sciatic nerve (SN) and dorsal root ganglia (DRG) during experimental diabetes. Streptozotocin-induced (STZ; 4, 8, and 12 weeks; 65 mg/kg; ip) diabetic rats (DB) and age
Braz J Med Biol Res. Publicado em: 03/06/2019
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2. Familial Dysautonomia: Mechanisms and Models
Abstract Hereditary Sensory and Autonomic Neuropathies (HSANs) compose a heterogeneous group of genetic disorders characterized by sensory and autonomic dysfunctions. Familial Dysautonomia (FD), also known as HSAN III, is an autosomal recessive disorder that affects 1/3,600 live births in the Ashkenazi Jewish population. The major features of the disease are
Genet. Mol. Biol.. Publicado em: 04/08/2016
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3. Insights into the Melipona scutellaris (Hymenoptera, Apidae, Meliponini) fat body transcriptome
The insect fat body is a multifunctional organ analogous to the vertebrate liver. The fat body is involved in the metabolism of juvenile hormone, regulation of environmental stress, production of immunity regulator-like proteins in cells and protein storage. However, very little is known about the molecular mechanisms involved in fat body physiology in sting
Genet. Mol. Biol.. Publicado em: 2013
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4. Desenvolvimento de vetores não virais para entrega gênica baseados na cadeia leve de dineína Rp3 = : Development of non viral vectors for gene delivery based on dynein light chain Rp3 / Development of non viral vectors for gene delivery based on dynein light chain Rp3
Gene delivery is a promising technique with great medical potential that consists in the introduction of exogenous nucleic acids, and can be applied for gene therapy as well as DNA vaccination. However, its use is still limited by the lack of an ideal delivery vector, which is both safe and efficient. Although much more effective, viral vectors still raise s
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/07/2012
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5. Aperfeiçoamento da fermentação de sacarose através da modificação da expressão dos genes SUC2 e AGT1 em linhagens diploides de Saccharomyces cerevisiae. / Improvement of sucrose fermentation by modifying the expression of SUC2 and AGT1 genes in diploid Saccharomyces cerevisiae strains.
Currently, the S. cerevisiae strains used in industrial production of fuel alcohol in Brazil are diploid yeasts that of metabolize sucrose through its extracellular hydrolysis by the periplasmic invertase, followed by the transport of the formed glucose and fructose into the cells, and further metabolism through glycolysis. In this study, utilizing genetic e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/03/2012
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6. Modulação do transporte de prótons em osteoclastos: efeitos da acidose e do fluxo de fluido extracelular. / Modulation of proton transport in osteoclasts. Effects of acidosis and extracellular fluid flow.
Metabolic acidosis can cause a loss of bone mineral and the mechanic stimulation can cause adaptative bone remodeling. The bone resorption characteristic of these bone changes aforementioned depends on the extracellular acidification by osteoclastmediated proton secretion. The H+ secretion by vacuolar H+-ATPase together with Clsecretion through a Cl-/H+ exch
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/10/2011
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7. Expressão do receptor de macrófago com estrutura de colágeno (MARCO) em macrófagos, células dendríticas e células tumorais após internalização de nanotubos de carbono / Expression of macrophage receptor with collagen structure (MARCO) in macrophages, dendritic cells and tumor cells after internalization of carbon nanotubes
The aplication of nanotechnology emerges with potential for application in the biomedical area, pathological diagnosis and treatment, drug transport and intracellular transport of molecules. Among the nanoparticles, carbon nanotubes (NT) belong to a new class of material for application in the biomedical area. Due to its small size, the NT can be internalize
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
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8. Caracterização fisiológica e genética do transporte de arginina em Leishmania (Leishmania) amazonensis / Physiologic and genetic characterization of arginine transport in Leishmania (Leishmania) amazonensis
Protozoan of genus Leishmania are digenetic parasites that present a stage in the life in insect gut (promastigotes) and an intracellular phase (amastigotes) inside vertebrate host macrophages. The study of L-arginine influx consists in an interesting matter, since the amino acid is used on NO production pathway (the main macrophage microbial pathway) but ar
Publicado em: 2011
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9. Albumina modificada por glicação avançada no diabete melito tipo 1 e 2 prejudica o transporte reverso de colesterol e favorece o acúmulo de lípides em macrófagos / Impairment in reverse cholesterol transport and macrophage lipid accumulation induced by advanced glycated albumin drawn from uncontrolled type 1 and type 2 diabetes mellitus patients
Advanced glycation end products are prevalent in diabetes mellitus and alter lipids and lipoprotein metabolism. In this study we analyzed the role of albumin, isolated from control individuals (C, n = 12) and uncontrolled type 1 (DM 1, n = 13) and type 2 (DM 2, n = 11) diabetes mellitus patients on macrophage cholesterol removal, intracellular lipid accumula
Publicado em: 2011
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10. Physiological implications of the regulation of vacuolar H+-ATPase by chloride ions
Vacuolar H+-ATPase is a large multi-subunit protein that mediates ATP-driven vectorial H+ transport across the membranes. It is widely distributed and present in virtually all eukaryotic cells in intracellular membranes or in the plasma membrane of specialized cells. In subcellular organelles, ATPase is responsible for the acidification of the vesicular inte
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-02
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11. Transporte de hormônios tireoideanos em hemácias de pacientes com hipertireoidismo ou hipotireoidismo primário
Thyroid hormones (THs) have important effects on cellular growth, differentiation and metabolism. They bind to thyroid hormone receptors (TRs), which belong to the nuclear hormone receptor superfamily. Because TRs are located intracellularly, TH action requires its transport from the extracellular compartment into target cells. It has become increasingly cle
Publicado em: 2009
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12. Effect of glucose on pHi recovery in HEK-293 cells. / Efeito da glicose sobre recuperação do pHi em células HEK-293.
Os estudos foram realizados em cultura de células HEK-293 (human embrionic kidney cells). Por microscopia de fluorescência, avaliou-se a velocidade de recuperação do pHi (dpHi/dt). Por Western blot, avaliou-se a expressão de SGLTs e NHEs e a translocação dos SGLTs foi avaliada por imunofluorescência. Resultados: No controle, a dpHi/dt foi de 0,169 ±
Publicado em: 2009