Intratracheal
Mostrando 1-12 de 261 artigos, teses e dissertações.
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1. Tadalafil-loaded PLGA microspheres for pulmonary administration: preparation and evaluation
Tadalafil, a long-acting PED-5 inhibitor, is commonly used for the treatment of pulmonary arterial hypertension (PAH). However, its efficacy and clinical application are severely limited by the poor water solubility, low bioavailability and a series adverse effects (e.g. headaches, indigestion). In this study, tadalafil was prepared and loaded into biodegrad
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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2. Biopersistence of fibrous thermal insulations (AES fibers) after heat exposure using intratracheal instillation technique
Resumo Pelo fato das fibras cerâmicas refratárias (FCR) serem classificadas como agentes possivelmente patogênicos à espécie humana, as fibras de silicato de metais alcalino-terrosos (AES) podem ser utilizadas como potenciais substitutos. Os experimentos in vivo que avaliaram a patogenicidade das fibras AES utilizaram esse produto in natura. A classific
Cerâmica. Publicado em: 2019-01
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3. Effect of hypertonic saline treatment on the inflammatory response after hydrochloric acid-induced lung injury in pigs
OBJECTIVES:Hypertonic saline has been proposed to modulate the inflammatory cascade in certain experimental conditions, including pulmonary inflammation caused by inhaled gastric contents. The present study aimed to assess the potential anti-inflammatory effects of administering a single intravenous dose of 7.5% hypertonic saline in an experimental model of
Clinics. Publicado em: 2015-08
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4. Indicadores de prognósticos clínicos de deglutição funcional em pacientes de um hospital público de grande porte / Clinical prognostic indicators of swallowing functional outcome of patients from a large Brazilian hospital
INTRODUÇÃO: A presença da disfagia pós-extubação é bem documentada na literatura, com alta prevalência na maior parte dos estudos. No entanto, há relativamente poucos estudos que apresentam indicadores específicos referentes ao acompanhamento destes pacientes até o momento da alta hospitalar. O objetivo desta tese é determinar os indicadores de p
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/12/2012
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5. Disfagia orofaríngea em pacientes submetidos à intubação orotraqueal prolongada em UTIs / Oropharyngeal dysphagia in patients submitted to prolonged orotracheal intubation in intensive care units
INTRODUÇÃO: A deglutição é um processo complexo que requer a coordenação precisa de mais de 25 músculos, seis pares de nervos cranianos e os lobos frontais. O comprometimento neste processo, denominado de disfagia, pode aumentar a taxa de morbidade dos pacientes e também o risco para a aspiração, retardando a administração de uma nutrição adeq
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/11/2012
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6. Desenvolvimento, caracterização físico-química e avaliação farmacocinética de nanopartículas auto-organizadas de quitosana / Development, physico-chemical characterization and pharmacokinetic evaluation of self-assembly chitosan nanoparticules
Objectives: Nanoparticles (NP) are useful to modulate the pharmacokinetics (PK) of drugs. The aim of this study was to develop innovative self-assembly nanovesicles (NV) constituted of chitosan and lecithin with isopropyl myristate (IPM) as oil core, able to modify the PK plasma profile of clozapine (CZP) and valproic acid (VPA). Methods: The NV were obtaine
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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7. Resposta molecular do endotélio pulmonar à exposição aguda de material particulado fino / Molecular response of pulmonary endothelial cells to acute exposure to fine particulate matter
Epidemiological studies establish a clear association between air pollution and increased cardiovascular and respiratory morbidity and mortality. However, the molecular mechanisms underlying the effect of fine particulate matter (PM2,5) are still poorly understood. The aim of this study was to characterize the impact of exposure to PM2,5 on the biology of pu
Publicado em: 2010
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8. Rapid sequence intubation evaluation in a tertiary pediatric emergency department / Avaliação da sequência rápida de intubação em pronto-socorro pediátrico terciário
Os primeiros indícios de tentativas de abordagem e manejo da via aérea (VA) datam de cerca de 4000 anos. A intubação traqueal (IT) consiste na introdução de um tubo na luz da traquéia, e é responsável por salvar muitas vidas. O manejo da VA nos serviços de emergência é um dos principais desafios e seguramente um dos momentos mais críticos do cui
Publicado em: 2010
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9. Treatment of hemorrhagic shock with hypertonic saline solution modulates the inflammatory response to live bacteria in lungs
Shock and resuscitation render patients more susceptible to acute lung injury due to an exacerbated immune response to subsequent inflammatory stimuli. To study the role of innate immunity in this situation, we investigated acute lung injury in an experimental model of ischemia-reperfusion (I-R) followed by an early challenge with live bacteria. Conscious ra
Brazilian Journal of Medical and Biological Research. Publicado em: 04/09/2009
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10. High mobility group box 1 as a mediator of endotoxin administration after hemorrhagic shock-primed lung injury
High mobility group box 1 (HMGB1) was discovered as a novel late-acting cytokine that contributes to acute lung injury (ALI). However, the contribution of HMGB1 to two-hit-induced ALI has not been investigated. To examine the participation of HMGB1 in the pathogenesis of ALI caused by the two-hit hypothesis, endotoxin was injected intratracheally in a hemorr
Brazilian Journal of Medical and Biological Research. Publicado em: 31/07/2009
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11. Resistance of melanized yeast cells of Paracoccidioides brasiliensis to antimicrobial oxidants and inhibition of phagocytosis using carbohydrates and monoclonal antibody to CD18
Paracoccidioides brasiliensis, a thermal dimorphic fungal pathogen, produces a melanin-like pigment in vitro and in vivo. We investigated the involvement of carbohydrates and monoclonal antibody to CD18, on phagocytosis inhibition, involving macrophage receptors and the resistance of melanized fungal cells to chemically generated nitric oxide (NO), reactive
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07
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12. Protective effects of phosphodiesterase inhibitors on lung function and remodeling in a murine model of chronic asthma
The aim of the present study was to compare the efficacy of a novel phosphodiesterase 4 and 5 inhibitor, LASSBio596, with that of dexamethasone in a murine model of chronic asthma. Lung mechanics (airway resistance, viscoelastic pressure, and static elastance), histology, and airway and lung parenchyma remodeling (quantitative analysis of collagen and elasti
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-02