Intrinsic Dissolution
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Solubility evaluation of didanosine: a comparison between the equilibrium method and intrinsic dissolution for biopharmaceutics classification purposes
ABSTRACT BCS (Biopharmaceutics Classification System) and BDDCS (Biopharmaceutics Drug Disposition Classification System) were proposed as tools for classifying drugs into four categories. Both systems consider the solubility as an important characteristic for the classification of compounds in drug development and in vivo disposition prediction. Although so
Braz. J. Pharm. Sci.. Publicado em: 07/08/2017
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2. The effect of dissolution medium, rotation speed and compaction pressure on the intrinsic dissolution rate of amlodipine besylate, using the rotating disk method
A finalidade do presente trabalho foi avaliar o efeito do meio de dissolução, velocidade de rotação e pressão de compactação na velocidade de dissolução intrínseca (VDI) do fármaco anti-hipertensivo besilato de anlodipino, usando o método do disco rotativo. Dessa forma, foi utilizado um planejamento experimental do tipo fatorial facionado (33-1)
Braz. J. Pharm. Sci.. Publicado em: 2014-09
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3. Equilibrium solubility versus intrinsic dissolution: characterization of lamivudine, stavudine and zidovudine for BCS classification
A solubilidade e a taxa de dissolução de fármacos são de grande importância em estudos de pré-formulação de formas farmacêuticas. A melhora na solubilidade permite que os fármacos sejam candidatos potenciais à bioisenção, podendo ser uma boa maneira para desenvolver formulações dose-eficientes. O comportamento de solubilidade da lamivudina, es
Braz. J. Pharm. Sci.. Publicado em: 2013-12
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4. Avaliação do impacto de diferentes variáveis no ensaio de dissolução intrínseca de metronidazol / Evaluation of the impact of different variables in the intrinsic dissolution test for metronidazole
O objetivo do presente trabalho foi avaliar o impacto de diferentes variáveis no ensaio de dissolução intrínseca de metronidazol. Inicialmente, as amostras, com diferentes graus de micronização, foram submetidas à caracterização físico-química, sendo realizados ensaios de solubilidade, tamanho de partícula, análise térmica (DSC/ TG), infraverme
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
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5. Estudos de correlaÃÃo de parÃmetros tÃrmicos e de dissoluÃÃo do fluconazol na caracterizaÃÃo tecnolÃgica de desintegrantes
The real need to develop, to produce and to market drugs with high quality level, allied the diversity of products pharmaceutical resultant of different synthesis and purification processes, do one of the improvement of the control of quality of the raw materials of the great challenges of the pharmaceutical industries. The present work studies the correlati
Publicado em: 2008
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6. Estudos de correlaÃÃo da estabilidade tÃrmica e dissoluÃÃo intrÃnseca do Albendazol e os parÃmetros farmacotÃcnicos das suas formulaÃÃes
A indÃstria farmacÃutica brasileira vem enfrentando novos desafios no desenvolvimento tecnolÃgico em virtude da baixa qualidade das matÃrias-primas farmacÃuticas que sÃo comercializadas no paÃs. O presente trabalho estuda a correlaÃÃo de tÃcnicas analÃticas visando à obtenÃÃo de parÃmetros da qualidade tecnolÃgica da matÃria-prima ativa albe
Publicado em: 2007
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7. Thin films of lead iodide (PbI2) produced by spray pyrolysis / Filmes finos de iodeto de chumbo (PbI2)produzidos por spray pyrolysis
Researchers in the whole world search alternative methods that minimize the time of deposition of thin films of promising semiconductor candidates for medical applications, such as X-rays detectors for digital radiography. Lead iodide (PbI2) has been among those as a good candidate for the fabrication of room temperature detectors. Other authors have fabrica
Publicado em: 2003
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8. The influence of swelling capacity of superdisintegrants in different pH media on the dissolution of hydrochlorothiazide from directly compressed tablets
The purpose of this study was to investigate the efficiency of superdisintegrants in promoting tablet disintegration and drug dissolution under varied media pH. Significant reductions in the rate and extent of water uptake and swelling were observed for both sodium starch glycolate (Primojel) and croscarmellose sodium (Ac-Di-Sol) in an acidic medium (0.1 N H
Springer-Verlag.
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9. Evaluation of the stability of creatine in solution prepared from effervescent creatine formulations
The objectives of this study were to determine the cause of the crystallization in a large volume creatine supplement solution made from effervescent powders containing di-creatine citrate, and to characterize these crystals using thermal analyses and x-ray diffractometry. Creatine effervescent powders were dissolved in deionized water (pH 6.2) and stored bo
Springer-Verlag.
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10. Comparison between gamma and beta irradiation effects on hydroxypropylmethylcellulose and gelatin hard capsules
The effects of electron beam or λ-irradiation on technological performances (capsule hardness, expressed as deforming work and dissolution time) of empty 2-shell capsules made of gelatin or hydroxypropylmethylcellulose (HPMC) were studied. Capsule structural changes induced by radiation treatment were investigated by capillary viscometry and atomic force mi
Springer-Verlag.
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11. Preparation and physicochemical characterization of 5 niclosamide solvates and 1 hemisolvate
The purpose of the study was to characterize the physicochemical, structural, and spectral properties of the 1∶1 niclosamide and methanol, diethyl ether, dimethyl sulfoxide, N,N' dimethylformamide, and tetrahydrofuran solvates and the 2∶1 niclosamide and tetraethylene glycol hemisolvate prepared by recrystallization from these organic solvents. Structura
Springer-Verlag.
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12. Generalization of a prototype intelligent hybrid system for hard gelatin capsule formulation development
The aim of this project was to expand a previously developed prototype expert network for use in the analysis of multiple biopharmaceutics classification system (BCS) class II drugs. The model drugs used were carbamazepine, chlorpropamide, diazepam, ibuprofen, ketoprofen, naproxen, and piroxicam. Recommended formulations were manufactured and tested for diss
Springer-Verlag.