Investigational
Mostrando 1-12 de 158 artigos, teses e dissertações.
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1. The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics
Social anxiety disorder (SAD) is a highly prevalent psychiatric disorder that presents with an early age of onset, chronic disease course, and increased risk of psychiatric comorbidity. Current treatment options for SAD are associated with low response rates, suboptimal efficacy, and possible risk of adverse effects. Investigation of new neurobiological mech
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Calcineurin inhibitors revisited: A new paradigm for COVID-19?
Abstract The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can cause mild, moderate or severe disease (COVID-19). In severe disease, there is hyperinflammation causing severe symptoms. Severe COVID-19 is an immunological phenomenon, rather than a direct viral damage disease. Therapies for COVID-19 are all investigational therapies. In case of
Braz J Infect Dis. Publicado em: 2020-08
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3. Treatment and research lines for the patient with COVID-19. What do we have and where are we going?
ABSTRACT Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the most significant global public health crisis of this generation. From the beginning of the pandemic, several publications and on-line resources about different treatment lines have been done, and development effort in response to
Int. braz j urol.. Publicado em: 2020-07
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4. Use of remdesivir for patients with Covid-19: a review article
RESUMO O agente etiológico da COVID-19, que causa doenças respiratórias graves, como pneumonia e insuficiência pulmonar, foi confirmado como um novo coronavírus, agora conhecido como coronavirus de síndrome respiratória aguda grave 2 (SARS-CoV-2). Não existem atualmente medicamentos autorizados para o tratamento de COVID-19, nem estão também autori
Rev. Assoc. Med. Bras.. Publicado em: 2020-06
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5. ATTENTION ON CONTRACEPTION BY FAMILY HEALTH TEAMS: CONVERGENCE OF EDUCATIONAL AND INVESTIGATIONAL PRACTICES
RESUMO Objetivo: construir ações de saúde em conjunto com equipes de Saúde da Família para aperfeiçoar a atenção em anticoncepção. Método: pesquisa qualitativa, na modalidade convergente-assistencial, com suporte teórico-metodológico do Apoio Paideia. Coleta de dados por meio de entrevistas semiestruturadas e grupos de convergência. Participa
Texto contexto - enferm.. Publicado em: 09/12/2019
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6. Postoperative Cognitive Dysfunction after Coronary Artery Bypass Grafting
Abstract Postoperative cognitive dysfunction is a common complication following cardiac surgery. The incidence of cognitive dysfunction is more pronounced in patients receiving a cardiac operation than in those undergoing a non-cardiac operation. Clinical observations demonstrated that pulsatile flow was superior to nonpulsatile flow, and membrane oxygenator
Braz. J. Cardiovasc. Surg.. Publicado em: 2019-02
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7. Efficiency of Single Site Phase Transfer Catalyst in Free Radical Polymerization of Butyl Methacrylate - A Kinetic Study
ABSTRACT The effectiveness of single site phase transfer catalyst- 2- benzoylethyldecyldimethylammonium bromide has been studied with the help of kinetics of free radical polymerization of butyl methacrylate. The radical polymerization was catalysed with single site phase transfer catalyst, initiated by water soluble potassium peroxydisulphate initiator in e
Braz. arch. biol. technol.. Publicado em: 23/01/2017
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8. Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies
The process of drug development involves non-clinical and clinical studies. Non-clinical studies are conducted using different protocols including animal studies, which mostly follow the Good Laboratory Practice (GLP) regulations. During the early pre-clinical development process, also known as Go/No-Go decision, a drug candidate needs to pass through severa
Braz J Med Biol Res. Publicado em: 12/12/2016
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9. Neurotoxic Effects Associated with Current Uses of Organophosphorus Compounds
Organophosphorus compounds (OPs) are a large and diverse class of chemicals that have been synthesized, since the XIX century for several purposes like chemical weapons, flame-retardants, ectoparasiticides and investigational new drugs, but mainly as agrochemicals in agriculture and indoor. Although the amount of OP pesticides being used is declining, especi
J. Braz. Chem. Soc.. Publicado em: 2016-05
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10. Guidelines for diagnosis and treatment of Hunter Syndrome for clinicians in Latin America
This review aims to provide clinicians in Latin America with the most current information on the clinical aspects, diagnosis, and management of Hunter syndrome, a serious and progressive disease for which specific treatment is available. Hunter syndrome is a genetic disorder where iduronate-2-sulfatase (I2S), an enzyme that degrades glycosaminoglycans, is ab
Genet. Mol. Biol.. Publicado em: 2014-06
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11. A review of continuous vs intermittent androgen deprivation therapy: Redefining the gold standard in the treatment of advanced prostate cancer. Myths, facts and new data on a perpetual dispute
Objectives: To review the literature and present new data of continuous androgen deprivation therapy (ADT) vs intermittent androgen deprivation (IAD) as therapies for prostate cancer in terms of survival and quality of life and clarify practical issues in the use of IAD. Materials and Methods: We conducted a systematic search on Medline and Embase databas
Int. braz j urol.. Publicado em: 2014-01
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12. Artroplastia total de disco com Mobi-C(r) depois de três anos
Objetivo: Avaliar a segurança e a eficácia da artroplastia total de disco (ATD) em dois níveis, usando o disco cervical artificial Mobi-C(r) aos 36 meses de acompanhamento. Métodos: Realizou-se estudo clínico prospectivo, randomizado, controlado e multicêntrico de disco cervical artificial (Mobi-C(r)) regido pelas regulamentações de Investigational D
Coluna/Columna. Publicado em: 2014