Iodocyclization
Mostrando 1-3 de 3 artigos, teses e dissertações.
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1. Synthesis and Cytotoxic Evaluation of 1H-1,2,3-Triazol-1-ylmethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-diones
ABSTRACT The 1,2-naphthoquinone compound was previously considered active against solid tumors. Moreover, glycosidase inhibitors such as 1,2,3-1H triazoles has been pointed out as efficient compounds in anticancer activity studies. Thus, a series of eleven 1,2-naphthoquinones tethered in C2 to 1,2,3-1H-triazoles 9a-k were designed, synthesized and their cyto
An. Acad. Bras. Ciênc.. Publicado em: 15/02/2018
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2. Synthesis of Diiodo-Functionalized Benzo[b]furans via Electrophilic Iodocyclization
An electrophilic iodocyclization reaction involving alkynylated 2-iodoanisoles and molecular iodine in the presence of sodium bicarbonate was developed and diiodo-functionalized benzo[b]furans were obtained in yields from 45 to 99%.
J. Braz. Chem. Soc.. Publicado em: 2017-10
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3. β-enamine esters as precursors of GABA and dihydropyridines analogues / bβ-enamino ésteres como precursores de análogos do GABA e de di-hidropiridinas
This thesis presents a study of iodo-cyclization of β-enamino esters in order to obtain conformationally restricted analogues of γ-amino butiric acid (GABA) and of 1,4-dihydropyridines (DHPs). Trisubstituted cyclopentanes were obtained from iodo-β-enamino esters and the mechanism of their formation was proposed and corroborated by (+)-ESI-MS/M
Publicado em: 2006