Ionic Channel
Mostrando 1-12 de 339 artigos, teses e dissertações.
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1. Programa de computador para simulação de modelos de neurônios: aplicação à célula mitral do bulbo olfatório / Computer program for neuron models simulation: application to the olfactory bulb mitral cell
O presente trabalho descreve um programa de computador em linguagem Java que reproduz o modelo compartimental reduzido de célula mitral do bulbo olfativo construído por Davison, Feng e Brown (Brain Res. Bull. 51:393-399,2000), como uma simplificação do modelo detalhado de Bhalla e Bower (J. Neurophysiol., 69:1948-1965, 1993). O modelo reduzido considera
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/06/2011
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2. A computer simulation study of motoneuron models with active dendrites in response to synaptic inputs. / Estudo por simulação computacional de modelos de motoneurônios com dendrito ativo em resposta a entradas sinápticas.
Mathematical models of motoneurons have been developed as an aid to the understanding of phenomena involving the neuromuscular system, but most of these models have been based on the hypothesis of a passive dendritic tree. This holds for anesthetized animals but not necessarily during normal motor behavior of the intact animal. Experiments with decerebrate a
Publicado em: 2010
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3. MHD flow of micropolar fluid in a rectangular duct with hall and ion slip effects
The steady flow of incompressible and electrically conducting micropolar fluid flow through a rectangular channel is considered taking Hall and ionic effects into consideration. An external uniform magnetic field is applied which is directed arbitrary in a plane perpendicular to the flow direction. The governing partial differential equations are solved nume
Journal of the Brazilian Society of Mechanical Sciences and Engineering. Publicado em: 2008-12
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4. A mechanistic view of mitochondrial death decision pores
Mitochondria increase their outer and inner membrane permeability to solutes, protons and metabolites in response to a variety of extrinsic and intrinsic signaling events. The maintenance of cellular and intraorganelle ionic homeostasis, particularly for Ca2+, can determine cell survival or death. Mitochondrial death decision is centered on two processes: in
Brazilian Journal of Medical and Biological Research. Publicado em: 12/04/2007
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5. Estudo do Segmento Consenso Adjacente ao Domínio TM2 e parte do Domínio TM2 do Receptor P2X7: Dinâmica Molecular e Atividade de Canal Iônico. / Study of the segment adjacent consensus to domain TM2 and part of domain TM2 of receiver P2X7: molecular dynamics and activity of ionic canal.
The purinergic receptor P2X7 (P2X7R) is a membrane protein which forms channels in the presence of extracellular ATP. Once opened, the channels allow the transport of cations through the cellular membrane, being expressed preferentially in immune cells. Among all purinergic receptors, P2X7R has distinct characteristics from other P2X (P2XR) members. For exam
Publicado em: 2007
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6. Estudo das propriedades biofísicas e farmacológicas do poro associado ao receptors P2X7 e poros de características similares. / Study of the biophysical and pharmacological properties of the pore associated with receiver P2X7 and pores of similar characteristics.
The P2X7 receptor (EC50= ~100μM) induces cell membrane permeabilization to molecules up to 900 Da when activated by high ATP concentrations. So far, the correlation between the opening of low conductance cationic channel (8 pS) formed after stimulation with low ATP concentrations (EC50= ~1 μM) and the opening of P2X7 related pore is unclear. To dat
Publicado em: 2006
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7. Toxicity of puffer fish: two species (Lagocephalus laevigatus, linaeus 1766 and Sphoeroides spengleri, Bloch 1785) from the Southeastern Brazilian coast
In Brazil, where puffer fish are considered poisonous, there are few documented cases on human consumption and consequent poisoning. In this study, toxicity of two puffer fish species from the Brazilian coast was examined. Specimens of Sphoeroides spengleri and Lagocephalus laevigatus were caught in São Sebastião Channel (North coast of São Paulo State, B
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2003
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8. Microemulsões a base de óleos vegetais: formação, propriedades e emprego na descontaminação EX-SITU de Solo / Vegetable oil-based microemulsions: formation, properties and application for "exsitu" soil decontamination
In the present project, we were interested in assessing the use of Brazilian vegetable oils in the "ex-situ" decontamination of soils from polycyclic aromatic hydrocarbons (PAHs). In this process, contaminated soil is treated with a microemulsion (µE) composed of water (W) /commercial non-ionic surfactant (S) C9/11EO4 /oil (O). The latter term refers to the
Publicado em: 2000
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9. [3H]Phencyclidine: a probe for the ionic channel of the nicotinic receptor.
To evaluate [3H]phencyclidine ([3H]PCP)as a probe for the ionic channel of the nicotinic receptor, the characteristics of its binding to electric organ membranes od Torpedo ocellata and its effects on frog sartorius muscle were studied. Similar to PCP, [3H]PCP depressed the peak amplitude of endplate current, caused nonlinearity in the voltage-current relati
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10. Electrophysiological and biochemical studies on enhancement of desensitization by phenothiazine neuroleptics.
The actions of the phenothiazines chlorpromazine, prochlorperazine, and trifluoperazine were studied on the acetylcholine receptor-ionic channel complex of frog and rat skeletal muscle and of Torpedo californica to determine their role in pharmacological desensitization and their interactions with different states of the receptor-ionic channel complex. The p
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11. The SecY complex forms a channel capable of ionic discrimination
Protein translocation across the bacterial membrane occurs at the SecY complex or channel. The resting SecY channel is impermeable to small molecules owing to a plug domain that creates a seal. Here, we report that a channel loosely sealed, or with a plug locked open, does not, however, lead to general membrane permeability. Instead, strong selectivity towar
Nature Publishing Group.
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12. Endocytosis as a Mechanism for Tyrosine Kinase-dependent Suppression of a Voltage-gated Potassium Channel
The voltage-gated potassium channel Kv1.2 undergoes tyrosine phosphorylation-dependent suppression of its ionic current. However, little is known about the physical mechanism behind that process. We have found that the Kv1.2 alpha-subunit protein undergoes endocytosis in response to the same stimuli that evoke suppression of Kv1.2 ionic current. The process
The American Society for Cell Biology.