Isoprenoids
Mostrando 1-12 de 70 artigos, teses e dissertações.
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1. Cloning and Characterization of the Gene Encoding 3-hydroxy-3- Methylglutaryl-coenzyme A (HMG-CoA) Reductase from Fritillaria Cirrhosa D. Don
ABSTRACT The enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR; EC1.1.1.34) catalyzes the first committed step of isoprenoids biosynthesis in Mevalonate (MVA) pathway. Here we report for the first time the cloning and characterization of a full-length cDNA encoding HMGR from Fritillaria cirrhosa (FcHMGR), a bulbous medicinal plant. The full-length cDNA o
Braz. arch. biol. technol.. Publicado em: 29/11/2018
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2. Developing Commercial Production of Semi-Synthetic Artemisinin, and of β-Farnesene, an Isoprenoid Produced by Fermentation of Brazilian Sugar
The antimalarial drug artemisinin and the specialty chemical β-farnesene are examples of natural product isoprenoids that can help solve global challenges, but whose usage has previously been limited by supply and cost impediments. This review describes the path to commercial production of these compounds utilizing fermentation of engineered yeast. Developm
J. Braz. Chem. Soc.. Publicado em: 2016-08
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3. Processos naturais de biodegradação do petróleo em reservatórios
Petroleum biodegradation in reservoirs is a process caused by different microorganisms affecting many oil deposits which modifies the oil composition in a quasi-stepwise process starting from n-alkanes and isoprenoids through to diasteranes. This causes oil souring and increased viscosity, sulfur and metal content, having a direct impact on oil production an
Quím. Nova. Publicado em: 2012
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4. Biossíntese de vitamina E nos estágios intraeritrocitários de P. falciparum. / Vitamin E biosynthesis in intraerythrocytic stages of Plasmodium falciparum.
The study of isoprenoid biosynthesis in Plasmodium falciparum by 2C-methyl-D-erythritol-4-phosphate pathway (MEP) it is presented as a therapeutic target once that it is absent in humans. It was found in intraerythrocytic stages of P. falciparum the biosynthesis of isoprenoids by the MEP pathway. The shikimate and MEP pathways are the precursors of biosynthe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/02/2011
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5. Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum
The development of new drugs is one strategy for malaria control. Biochemical pathways localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are excellent targets because they are different or absent in the human host. Isoprenoids are a large and highly diverse group of natural products with many functions and their synt
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-08
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6. Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis
β-ionone (βI), a cyclic isoprenoid, and geraniol (GO), an acyclic monoterpene, represent a promising class of dietary chemopreventive agents against cancer, whose combination could result in synergistic anticarcinogenic effects. The chemopreventive activities of βI and GO were evaluated individually or in combination during colon carcinogenesis induced by
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-06
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7. Clonagem, caracterização e expressão de genes envolvidos na síntese de compostos isoprenóides em Eucalyptus grandis
Isoprenoids are essential to all organisms and are the most structurally and functionally diverse group of plant metabolites. In plants, more than 30,000 compounds of this class were identified to date. All plants produce isoprenoids that can play essential roles as carotenoids, chlorophylls and plastoquinone (photosynthesis); ubiquinone (respiration); regul
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
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8. Preparação e avaliação farmacológica de derivados dos lipídios fenólicos do líquido da casca da castanha de caju
The present work describes the utilization of Cashew Nut-Shell Liquid (CNSL), abundant source of phenolic non-isoprenoids lipids from our country, as raw material for preparation of compounds with synthetic applications as well as biological useful. The extraction, separation and characterization of CNSL phenolic nonisoprenoids lipids were done by procedures
Publicado em: 2008
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9. Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum
In Plasmodium falciparum, the formation of isopentenyl diphosphate and dimethylallyl diphosphate, central intermediates in the biosynthesis of isoprenoids, occurs via the methylerythritol phosphate (MEP) pathway. Fosmidomycin is a specific inhibitor of the second enzyme of the MEP pathway, 1-deoxy-D-xylulose-5-phosphate reductoisomerase. We analyzed the effe
Memórias do Instituto Oswaldo Cruz. Publicado em: 2007-06
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10. Determinação de fontes de hidrocarbonetos policíclicos aromáticos e alifáticos em sedimentos de ambientes aquáticos
Numerical values of polycyclic aromatic hydrocabons and n-alkanes distribution indexes of sediments are important tools to elucidate the origins of hydrocarbons mixtures. Polycyclic aromatic ratios are sensitive indicators of petrogenic and pyrogenic inputs, while n-alkanes distribution usualy discriminates biogenic from petrogenic sources. The study area of
Publicado em: 2006
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11. Estudo químico e perfil cromatográfico das cascas de Aspidosperma parvifolium A. DC. ("pau-pereira")
Four known alkaloids, uleine, epiuleine, apparicine and desmethyluleine, besides the isoprenoids lupeol and stigmasterol were isolated from the stem bark of Aspidosperma parvifolium. Their identification was based on spectroscopic analysis (UV, IR, ¹H-NMR, 13C-NMR, MS). The chromatographic profile of the ethanolic extract was obtained by HPLC and uleine, ep
Química Nova. Publicado em: 2004-12
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12. Atividade quimiopreventiva do farnesol e geraniol em ratos Wistar submetidos ao modelo de hepatocarcinogênese do hepatócito resistente" / Farnesol and gernariol chemopreventive activity in Wistar rats submitted to the "resistant hepatocyte"model of hepatocarcinogenesis
In the present study, the chemopreventive activity of farnesol (FR) and geraniol (GR), isoprenoids present in fruits and herbs, was evaluated when administered to Wistar rats during the initiation and/or selection/promotion phases of the "resistant hepatocyte" (RH) model of hepatocarcinogenesis. In Experimental Protocol 1, animals received during 8 consecuti
Publicado em: 2004