Kappa Opioid Receptor
Mostrando 1-12 de 50 artigos, teses e dissertações.
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1. Mecanismos opióides centrais envolvidos no efeito protetor da testosterona no desenvolvimento da dor da ATM em ratos / Central mu- kappa opioid receptor cooperativity mediates the protective effect of testosterone on temporomandibular joint nociception development in rats
Disfunções temporomandibulares são condições dolorosas que envolvem a articulação temporomandibular e os músculos mastigatórios com maior prevalência, severidade e duração no sexo feminino. Recentemente foi demonstrado que a testosterona apresenta um efeito protetor ao diminuir o risco de ratos desenvolverem dor na Articulação Temporomandibular
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2012
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2. Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression
The periaqueductal gray (PAG) has been reported to be a location for opioid regulation of pain and a potential site for behavioral selection in females. Opioid-mediated behavioral and physiological responses differ according to the activity of opioid receptor subtypes. The present study investigated the effects of the peripheral injection of the kappa-opioid
Braz J Med Biol Res. Publicado em: 2012-10
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3. Efeito da ativação local do receptor capa opióide no extravasamento plasmático e migração de neutrófilos na articulação temporomandibular de ratos / Effect of local activation of opioid kappa receptors in plasma extravasation and neutrophil migration in the temporomandibular joint in rats
In an attempt to decrease central side effects associated with the use of opioids, some strategies have been developed by targeting peripheral opioid receptors. In this context, kappa opioid receptors are of major interest, since, in contrast to other opioid receptors, their activation is not associated with potent peripheral side effects. We have recently d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2011
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4. Estudo dos mecanismos envolvidos no dimorfismo sexual da analgesia mediada por receptores opioides capa na articulação temporomandibular / Evaluation of mechanisms involved in a sexual dimorphism of analgesia mediated by kappa opioid receptor in temporomandibular joint
Recentemente foi demonstrado que a ativação de receptores capa opióides localizados na ATM de ratos reduz o comportamento nociceptivo induzido pela injeção se formalina na ATM de ratos, especialmente nas fêmeas na fase diestro do ciclo estral. Sendo a fase diestro aquela que representa baixos níveis hormonais, estes resultados indicam que os hormônio
Publicado em: 2006
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5. Participação dos receptores opioides capa perifericos na modulação da resposta nociceptiva induzida pela administração de formalina na ATM de ratos de diferentes sexos e fases do ciclo estral
Este estudo avaliou as diferenças sexuais na resposta nociceptiva induzida pela administração de formalina na articulação temporomandibular (ATM) com ou sem a co-administração do U50,488 (agonista do receptor opióide capa). As fases do ciclo estral das fêmeas foram citologicamente determinadas e apenas aquelas que apresentavam-se na fase diestro ou
Publicado em: 2004
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6. kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.
Using the mouse delta-opioid receptor cDNA as a probe, we have isolated genomic clones encoding the human mu- and kappa-opioid receptor genes. Their organization appears similar to that of the human delta receptor gene, with exon-intron boundaries located after putative transmembrane domains 1 and 4. The kappa gene was mapped at position q11-12 in human chro
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7. Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands.
Here we report the expression cloning of cDNA encoding a putative opioid receptor from a human placenta cDNA library. Placental opioid receptors are of the kappa type. As the dynorphin opioid peptides are kappa-selective, a dynorphin ligand was used in an affinity-enrichment (panning) procedure to select transiently transfected COS-7 cells expressing kappa r
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8. Primary structure and functional expression of a guinea pig kappa opioid (dynorphin) receptor.
A full-length cDNA encoding the guinea pig kappa opioid (dynorphin) receptor has been isolated. The deduced protein contains 380 aa and seven hydrophobic alpha-helices characteristic of the G protein-coupled receptors. This receptor is 90% identical to the mouse and rat kappa receptors, with the greatest level of divergence in the N-terminal region. When exp
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9. Cloning and pharmacological characterization of a rat kappa opioid receptor.
A full-length cDNA was isolated from a rat striatal library by using low-stringency screening with two PCR fragments, one spanning transmembrane domains 3-6 of the mouse delta opioid receptor and the other unidentified but homologous to the mouse delta receptor from rat brain. The novel cDNA had a long open reading frame encoding a protein of 380 residues wi
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10. Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors.
kappa opioid receptors (kappa receptors) have been characterized in homogenates of guinea pig and rat brain under in vitro binding conditions. kappa receptors were labeled by using the tritiated prototypic kappa opioid ethylketocyclazocine under conditions in which mu and delta opioid binding was suppressed. In the case of guinea pig brain membranes, a singl
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11. kappa-Opioid receptors also increase potassium conductance.
Decrease of calcium conductance induced by opioid agonists has been reported by others for mu-, delta-, and kappa-opioid receptors. On the other hand, only mu- and delta-opioid receptors have been reported to increase potassium conductance. Intracellular recordings were made from guinea pig substantia gelatinosa neurons in a brain slice. A subset of cells (2
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12. Immunomodulatory activity of mu- and kappa-selective opioid agonists.
Opioids and opioid peptides have been shown by numerous laboratories to modulate various parameters of the immune response, but little attention has been given to the type of opioid receptor that might be involved. This study focuses on the in vitro influences of morphine and DAMGE (Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol), mu-selective agonists, and U50,488H and U69,