Kelch Proteins
Mostrando 1-12 de 21 artigos, teses e dissertações.
-
1. Análise do transcriptoma regulado pela YakA e do papel de KeaA no desenvolvimento de Dictyostelium discoideum / Analysis of the YakA-regulated transcriptome and the role of KeaA in the regulation of Dictyostelium discoideum development
A YakA é uma proteína quinase necessária para a regulação da resposta a diversos estresses em Dictyostelium e é uma efetora chave da transição do crescimento para desenvolvimento nesse organismo. O gene keaA foi isolado como um supressor do mutante yakA- em uma busca para revelar genes envolvidos na sobrevivência a estresse nitrosoativo. O gene keaA
Publicado em: 2009
-
2. Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals
BioMed Central.
-
3. Mutations in Conserved Regions of the Predicted RAG2 Kelch Repeats Block Initiation of V(D)J Recombination and Result in Primary Immunodeficiencies†
The V(D)J recombination reaction is composed of multiple nucleolytic processing steps mediated by the recombination-activating proteins RAG1 and RAG2. Sequence analysis has suggested that RAG2 contains six kelch repeat motifs that are predicted to form a six-bladed β-propeller structure, with the second β-strand of each repeat demonstrating marked conserva
American Society for Microbiology.
-
4. Novel β-Propeller of the BTB-Kelch Protein Krp1 Provides a Binding Site for Lasp-1 That Is Necessary for Pseudopodial Extension*♦
Kelch-related protein 1 (Krp1) is up-regulated in oncogene-transformed fibroblasts. The Kelch repeats interact directly with the actin-binding protein Lasp-1 in membrane ruffles at the tips of pseudopodia, where both proteins are necessary for pseudopodial elongation. Herein, we investigate the molecular basis for this interaction. Probing an array of overla
American Society for Biochemistry and Molecular Biology.
-
5. Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I
BioMed Central.
-
6. Combining Single-Molecule Optical Trapping and Small-Angle X-Ray Scattering Measurements to Compute the Persistence Length of a Protein ER/K α-Helix
A relatively unknown protein structure motif forms stable isolated single α-helices, termed ER/K α-helices, in a wide variety of proteins and has been shown to be essential for the function of some molecular motors. The flexibility of the ER/K α-helix determines whether it behaves as a force transducer, rigid spacer, or flexible linker in proteins. In thi
The Biophysical Society.
-
7. Formation of the Drosophila Ovarian Ring Canal Inner Rim Depends on Cheerio
In Drosophila oogenesis, the development of a mature oocyte depends on having properly developed ring canals that allow cytoplasm transport from the nurse cells to the oocyte. Ring canal assembly is a step-wise process that transforms an arrested cleavage furrow into a stable intercellular bridge by the addition of several proteins. Here we describe a new ge
-
8. Characterization of Mayven, a Novel Actin-binding Protein Predominantly Expressed in Brain
The cytoskeleton plays an important role in neuronal morphogenesis. We have identified and characterized a novel actin-binding protein, termed Mayven, predominantly expressed in brain. Mayven contains a BTB (broad complex, tramtrack, bric-a-brac)/POZ (poxvirus, zinc finger) domain-like structure in the predicted N terminus and “kelch repeats” in the
The American Society for Cell Biology.
-
9. BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase
The concentrations and functions of many eukaryotic proteins are regulated by the ubiquitin pathway, which consists of ubiquitin activation (E1), conjugation (E2), and ligation (E3). Cullins are a family of evolutionarily conserved proteins that assemble by far the largest family of E3 ligase complexes. Cullins, via a conserved C-terminal domain, bind with t
American Society for Microbiology.
-
10. VP16 targets an amino-terminal domain of HCF involved in cell cycle progression.
The herpes simplex virus (HSV) regulatory protein VP16 activates HSV immediate-early gene transcription through formation of a multiprotein-DNA complex on viral promoters that includes the preexisting nuclear proteins HCF and Oct-1. The HCF protein is a complex of amino- and carboxy-terminal polypeptides derived from a large (approximately 2,000-amino-acid)
-
11. Clock-associated genes in Arabidopsis: a family affair.
The identification of components of the plant circadian clock has been advanced recently with the success of two forward genetics approaches. The ZEITLUPE and TOC1 loci were cloned and each was found to be part of two separate, larger gene families with intriguing domain structures. The ZTL family of proteins contains a subclass of the PAS domain coupled to
-
12. NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation
Cells respond to oxidants and electrophiles by activating receptor/transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) to coordinate the induction of cytoprotective genes critical for defense against oxidative and other stresses. Activation involves blocking the ubiquitination-proteasomal degradation of Nrf2. Modification of cysteine thio
The American Society for Pharmacology and Experimental Therapeutics.