L Type Calcium Channel
Mostrando 1-12 de 195 artigos, teses e dissertações.
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1. Cardiac function and intracellular Ca2+ handling proteins are not impaired by high-saturated-fat diet-induced obesity
Obesity is often associated with changes in cardiac function; however, the mechanisms responsible for functional abnormalities have not yet been fully clarified. Considering the lack of information regarding high-saturated-fat diet-induced obesity, heart function, and the proteins involved in myocardial calcium (Ca2+) handling, the aim of this study was to t
Braz J Med Biol Res. Publicado em: 27/05/2019
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2. Influence of antihypertensive drugs on aortic and coronary effects of Ang-(1-7) in pressure-overloaded rats
This study investigated the influence of antihypertensive drugs, such as angiotensin-converting enzyme inhibitors (ACEIs), AT1 receptor blockers (ARBs), voltage-gated L-type calcium channel blockers, and mineralocorticoid receptor antagonists (MRAs), on the effects of angiotensin-(1-7) [Ang-(1-7)] on aorta and coronary arteries from pressure-overloaded rats.
Braz J Med Biol Res. Publicado em: 23/03/2017
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3. Mibefradil reduces blood glucose concentration in db/db mice
OBJECTIVE: Numerous recent studies suggest that abnormal intracellular calcium concentration ([Ca2+]i) is a common defect in diabetic animal models and patients. Abnormal calcium handling is an important mechanism in the defective pancreatic β-cell function in type 2 diabetes. T-type Ca2+ channel antagonists lower blood glucose in type 2 diabetes, but the
Clinics. Publicado em: 2014-01
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4. Erythroxylum pungens elicits vasorelaxation by reducing intracellular calcium concentration in vascular smooth muscle cells of rats
The cardiovascular effects elicited by the ethanolic extract obtained from the roots of Erythroxylum pungens O.E. Schulz, Erythroxylaceae (EEEP) and the vasorelaxant effect induced by its main tropane alkaloid (pungencine) were investigated. In normotensive rats, administration of EEEP (1, 10, 30 and 60 mg/kg i.v., randomly) produced dose-dependent hypotensi
Revista Brasileira de Farmacognosia. Publicado em: 06/01/2012
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5. Expressão gênica e protéica do canal de cálcio do tipo L e seu envolvimento com o mecanismo de secreção de insulina em ilhotas de langerhans de ratos submetidos à restrição protéica e suplementados com leucina / Gene and protein expression of L type calcium channel and your involvement in the mechanism of insulin secretion in islets of Langerhans of rats submitted to protein restriction and supplementation with leucine
Voltage-dependent calcium channels (CaV) are plasma membrane proteins that lead calcium, and are activated by depolarization of the same by promoting the influx of this ion, which serves as an intracellular second messenger, turning electrical signals into chemical. This process controls several intracellular events such as exocytosis, endocytosis, muscle co
Publicado em: 2010
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6. A computer simulation study of motoneuron models with active dendrites in response to synaptic inputs. / Estudo por simulação computacional de modelos de motoneurônios com dendrito ativo em resposta a entradas sinápticas.
Mathematical models of motoneurons have been developed as an aid to the understanding of phenomena involving the neuromuscular system, but most of these models have been based on the hypothesis of a passive dendritic tree. This holds for anesthetized animals but not necessarily during normal motor behavior of the intact animal. Experiments with decerebrate a
Publicado em: 2010
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7. Participação Do Cálcio Citosólico Sobre A Ação Espasmolítica Do Ácido Ent-7a-Acetoxitraquiloban-18-Óico E De Seu Derivado Hidroxilado Em Íleo Isolado De Cobaia / Partipation of cytosolic calcium in spasmolytic action of ent-7a-acetoxytrachyloban-18-oic acid and its hidroxylated derivated on guinea-pig ileum
From the stem bark of Xylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae), popularly known as pimenteria da terra, was isolated the diterpene ent-7-α-acetoxytrachyloban-18-oic acid (trachylobane-360) from which it was made a structural modification in which the acetoxy group was substituted by hydroxy generating the ent-7a-hidroxitrachyloban-18-oic aci
Publicado em: 2010
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8. Efeitos pré e pós sinápticos dos inibidores da acetilcolinesterase na neurotransmissão em musculatura lisa.
Justification: The present work considers the effects of new inhibitors of acetylcholinesterase (AChE) on the reactivity and neurotransmission in rats and mice. The new anticholinesterase compounds, ITH12118 and ITH12117, have an hybrid stucture, derived from the molecule of of the anticholinesterase Tacrine and the 1,4 dihydropyridine nimodipine, a blocker
Publicado em: 2010
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9. Avaliação do efeito relaxante do BAY 41-2272 em detrusor isolado de coelhos / Evaluation of relaxant effect of BAY 41-2272 in rabbit isolated detrusor
Overactive bladder (OAB) is a highly prevalent condition that affects millions of people worldwide with a profound effect on quality of life. The bladder overactivity is related to spontaneous contractions of the detrusor smooth muscle causing an increase in the intravesical pressure and consequently stimulation of the micturirion reflex. Evidences suggest t
Publicado em: 2009
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10. Obesity induces upregulation of genes involved in myocardial Ca2+ handling
Obesity is a complex multifactorial disorder that is often associated with cardiovascular diseases. Research on experimental models has suggested that cardiac dysfunction in obesity might be related to alterations in myocardial intracellular calcium (Ca2+) handling. However, information about the expression of Ca2+-related genes that lead to this abnormality
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-07
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11. Influence of the 15-HETE on cytosolic [ Ca2+] i of the rabbit pulmonary artery smooth muscle cells
Extracellular Ca2+ influx was blocked by L-type Ca2+ channel blocker nifedipine to observe the effects of 15-hydroxyeicosatetraenoic acid on the constriction of rabbit pulmonary artery rings and on the changes of Ca2+ level in the rabbit pulmonary artery smooth muscle cells, and further to investigate the mechanism of the calcium mobilization induced by the
Brazilian Archives of Biology and Technology. Publicado em: 2008-04
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12. Effects of low-dose ionising radiation on pituitary adenoma: is there a role for L-type calcium channel?
Adenomas de pituitária constituem cerca de 6-18% dos tumores cerebrais em adultos. A ativação de correntes de cálcio dependentes de voltagem podem levar à super-excreção de hormônio do crescimento produzindo acromegalia e aumentando a mortalidade. Íons Ca2+ como mediadores de sinalização intracelular são cruciais no desenvolvimento da apoptose. N
Brazilian Archives of Biology and Technology. Publicado em: 2005-10