Lactam Bridge
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Estudos da ação de análagos cíclicos da angratensina II nos esporozóitas da Malária / Studies of the action of cyclic analogs of angiotensin II in the Malaria sporozoites
A malária é uma doença infecciosa, grave, causada por parasitas (protozoários do gênero Plasmodium) que são transmitidos principalmente, de uma pessoa para outra pela picada de mosquitos do gênero Anopheles. Mais de 300 milhões de pessoas são infectadas no mundo a cada ano. Drogas como a cloroquina, a mefloquina, entre outras podem ter efeitos colat
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/12/2009
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2. Influence of femB on methicillin resistance and peptidoglycan metabolism in Staphylococcus aureus.
The inactivation of FemB by insertion of Tn551 in the central part of the femB open reading frame was shown to increase susceptibility of methicillin-resistant Staphylococcus aureus strains toward beta-lactam antibiotics to the same extent as did inactivation of femA. Strains carrying the methicillin resistance determinant (mec) and expressing PBP 2' were af
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3. Biosynthesis of peptidoglycan in Gaffkya homari: on the target(s) of benzylpenicillin.
The formation of acceptor for the N epsilon-(D-Ala)-acceptor transpeptidase is an essential feature of nascent peptidoglycan processing. In Gaffkya homari the synthesis of cross-bridges in peptidoglycan includes a variety of penicillin-sensitive enzymes, e.g., transpeptidase, DD-carboxypeptidase, and LD-carboxypeptidase. To determine the primary target, we g
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4. Mechanism and Suppression of Lysostaphin Resistance in Oxacillin-Resistant Staphylococcus aureus
The potential for the development of resistance in oxacillin-resistant Staphylococcus aureus (ORSA) to lysostaphin, a glycylglycine endopeptidase produced by Staphylococcus simulans biovar staphylolyticus, was examined in vitro and in an in vivo model of infection. Following in vitro exposure of ORSA to subinhibitory concentrations of lysostaphin, lysostaphi
American Society for Microbiology.
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5. The CroRS Two-Component Regulatory System Is Required for Intrinsic β-Lactam Resistance in Enterococcus faecalis
Enterococcus faecalis produces a specific penicillin-binding protein (PBP5) that mediates high-level resistance to the cephalosporin class of β-lactam antibiotics. Deletion of a locus encoding a previously uncharacterized two-component regulatory system of E. faecalis (croRS) led to a 4,000-fold reduction in the MIC of the expanded-spectrum cephalosporin ce
American Society for Microbiology.
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6. Compounds which increase the permeability of the Pseudomonas aeruginosa outer membrane.
Hydrolysis of the chromogenic beta-lactam nitrocefin by periplasmic beta-lactamase in intact Pseudomonas aeruginosa cells was used to assess the influence of various compounds on the permeability of the P. aeruginosa outer membrane. In addition to the five previously described outer membrane-active compounds EDTA, polymyxin B, gentamicin, poly-L-lysine, and
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7. A nonpetide integrin antagonist can inhibit epithelial cell ingestion of Streptococcus pyogenes by blocking formation of integrin α5β1-fibronectin-M1 protein complexes
Streptococcus pyogenes can be efficiently internalized by a variety of human epithelial cells. β-lactam antibiotics, commonly used to treat S. pyogenes infections, do not readily permeate mammalian cells. There is growing evidence that the ability of streptococci to enter host cells contributes to the frequent failure of antibiotics to eradicate the or
The National Academy of Sciences.
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8. Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor.
Predictive methods, physicochemical measurements, and structure activity relationship studies suggest that corticotropin-releasing factor (CRF; corticoliberin), its family members, and competitive antagonists (resulting from N-terminal deletions) usually assume an alpha-helical conformation when interacting with the CRF receptor(s). To test this hypothesis f