Lactic Acidosis
Mostrando 1-12 de 102 artigos, teses e dissertações.
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1. Orthotopic Liver Transplantation in Glycogen Storage Disease Type 1a: Perioperative Glucose and Lactate Homeostasis
Abstract Glycogen storage disease type 1a (GSD 1a) is a rare inborn error of metabolism. It causes severe fasting intolerance and lactic acidosis due to the deficiency of glucose-6-phosphatase enzyme. Blood glucose and lactate concentrations from 2 patients with GSD 1a were retrospectively compared to a control group of patients with familial amyloid polyneu
J. inborn errors metab. screen.. Publicado em: 30/05/2019
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2. Arginine and Citrulline for the Treatment of MELAS Syndrome
Abstract Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a maternally inherited mitochondrial disease with a broad spectrum of manifestations. In addition to impaired energy production, nitric oxide (NO) deficiency occurs in MELAS syndrome and leads to impaired blood perfusion in microvasculature that can contri
J. inborn errors metab. screen.. Publicado em: 16/05/2019
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3. Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain
2-Hydroxybutyric acid appears at high concentrations in situations related to deficient energy metabolism (e.g., birth asphyxia) and also in inherited metabolic diseases affecting the central nervous system during neonatal development, such as "cerebral" lactic acidosis, glutaric aciduria type II, dihydrolipoyl dehydrogenase (E3) deficiency, and propionic ac
Publicado em: 2010
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4. Efeitos da acidose lática nos processos da contratilidade cardíaca do teleósteo de água doce matrinxã, Brycon cephalus
In the majority of the fish species already studied, cardiac force contraction is sensitive to small changes in the extracellular pH. During intense swimming, the increased lactic acid (LA) levels significantly reduce the Fc, impairing the myocardial contractile performance. The freshwater teleost matrinxã, Brycon cephalus, is a reofilic species presenting
Publicado em: 2009
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5. Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus
The introduction of highly active antiretroviral therapy (HAART) for the treatment of acquired immunodeficiency syndrome (AIDS) has resulted in greater survival of patients infected with the human immunodeficiency virus (HIV). However, the use of these drugs has been associated with lipodystrophic syndrome (LS), which is characterized by metabolic alteration
Brazilian Journal of Infectious Diseases. Publicado em: 2008-08
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6. Estudo associativo entre polimorfismos nos genes ND2 e ND3 que codificam para subunidades da NADH desidrogenase em DNA mitocondrial de pacientes esquizofrênicos
A esquizofrenia é uma doença neuropsiquiátrica que afeta cerca de 1% da população mundial e que, devido aos seus diversos sintomas, acarreta um enorme custo social direto (hospitalizações, atendimentos, medicações) e indireto (improdutividade, repercussões familiares). Os estudos de genética populacional indicam que a esquizofrenia tenha um compon
Publicado em: 2007
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7. Identification methods of physiological transition thresholds from intermittent progressive protocols with pause / Métodos de identificação do limiar de transição fisiológica em protocolo progressivo intermitente com pausa
The purpose of this work was to study identification methods of physiological transition thresholds from intermittent progressive protocols with pause. In addition, compare the values of speed, heart rate (HR) and blood lactate concentration ([La]) between different methods used. The participants were 10 male football players, with mean age of 19,99 1,75 yea
Publicado em: 2006
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8. An acid-sensing ion channel that detects ischemic pain
Ischemic pain occurs when there is insufficient blood flow for the metabolic needs of an organ. The pain of a heart attack is the prototypical example. Multiple compounds released from ischemic muscle likely contribute to this pain by acting on sensory neurons that innervate muscle. One such compound is lactic acid. Here, we show that ASIC3 (acid-sensing ion
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-11
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9. Determination of anaerobic threshold in rats using the lactate minimum test
The break point of the curve of blood lactate vs exercise load has been called anaerobic threshold (AT) and is considered to be an important indicator of endurance exercise capacity in human subjects. There are few studies of AT determination in animals. We describe a protocol for AT determination by the "lactate minimum test" in rats during swimming exercis
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-11
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10. Caracterização das principais mutações de ponto do DNA mitocondrial em um grupo de pacientes com doenças neurodegenerativas
Mitochondrial disease are genetic and clinic heterogeneous entities that are variable in age of onset, clinical severity and evolution. They are classified in abnormalities of nuclear DNA or mitochondrial DNA (mtDNA). Point mutations are found in mitochondrial genomes and most frequent phenotypes are MELAS (mitochondrial encephalomyopathy, lactic acidosis, a
Publicado em: 2002
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11. Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain
2-Hydroxybutyric acid appears at high concentrations in situations related to deficient energy metabolism (e.g., birth asphyxia) and also in inherited metabolic diseases affecting the central nervous system during neonatal development, such as "cerebral" lactic acidosis, glutaric aciduria type II, dihydrolipoyl dehydrogenase (E3) deficiency, and propionic ac
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-05
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12. Comparação da susceptibilidade de bovinos das raças Jersey e Gir à acidose láctica ruminal, induzida experimentalmente com sacarose / Studies on the susceptibility of Jersey (Bos taurus) and Gir (Bos indicus) steers to rumen lactic acidosis induced experimentally with sucrose
Foram utilizados neste experimento quatro garrotes Jersey (J) e quatro Gir (G), providos de cânula ruminal. Dois meses antes da indução da acidose láctica ruminal (ALR), os animais foram alimentados com dieta padronizada a base de feno e concentrado. A ALR foi induzida experimentalmente por meio da administração de sacarose intraruminal, correspondente
Publicado em: 2000