Lamotrigine
Mostrando 1-12 de 25 artigos, teses e dissertações.
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1. Development of a First-Order Derivative UV Spectrophotometric Method for the Assay and Solubility Evaluation of Lamotrigine and Nicotinamide Cocrystals
Pharmaceutical cocrystals are composed of a drug and a coformer and are currently gaining attention due to their possibility of improving drug solubility. Quantitative determination of cocrystals is usually carried out by liquid chromatography method, but an alternative for the same is derivative UV spectrophotometry. Cocrystals of lamotrigine (LAM) were for
J. Braz. Chem. Soc.. Publicado em: 2020-12
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2. Novo Qualis: rumos e rumores
Pharmaceutical cocrystals are composed of a drug and a coformer and are currently gaining attention due to their possibility of improving drug solubility. Quantitative determination of cocrystals is usually carried out by liquid chromatography method, but an alternative for the same is derivative UV spectrophotometry. Cocrystals of lamotrigine (LAM) were for
Rev. Bras. Hist.. Publicado em: 2020-12
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3. Influence of the clinical profile of patients with refractory epilepsy on lamotrigine plasma concentration
ABSTRACT The purpose of this work was to evaluate the influence of the clinical profile on lamotrigine (LTG) plasma concentrations from patients with refractory epileptic seizures. In this cross-sectional study, therapeutic monitoring of LTG, and questionnaires with 75 patients with refractory epileptic seizures of a Hospital in Ribeirão Preto-SP-Brazil wer
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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4. The use of aromatase inhibitors in boys with short stature: what to know before prescribing?
ABSTRACT Aromatase is a cytochrome P450 enzyme (CYP19A1 isoform) able to catalyze the conversion of androgens to estrogens. The aromatase gene mutations highlighted the action of estrogen as one of the main regulators of bone maturation and closure of bone plate. The use of aromatase inhibitors (AI) in boys with short stature has showed its capability to imp
Arch. Endocrinol. Metab.. Publicado em: 2017-08
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5. Identifying the incidence of rash, Stevens-Johnson syndrome and toxic epidermal necrolysis in patients taking lamotrigine: a systematic review of 122 randomized controlled trials
ABSTRACT Lamotrigine is an antiepileptic drug used for the treatment of epilepsy, bipolar disorder and numerous off-label uses. The development of rash significantly affects its use. The most concerning of these adverse reactions is Stevens-Johnson syndrome/toxic epidermal necrolysis. We performed a systematic review of randomized controlled trials using lam
An. Bras. Dermatol.. Publicado em: 2017-02
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6. Pharmacotherapy of bipolar disorder in children and adolescents: an update
Objective: To review the options for acute and maintenance pharmacological treatment of bipolar disorder in children and adolescents, including the treatment of bipolar depression and comorbid attention deficit/hyperactivity disorder (ADHD). Methods: Narrative review of randomized clinical trials and open-label studies published from 2000 to 2012. The Pub
Rev. Bras. Psiquiatr.. Publicado em: 2013-12
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7. Lamotrigine as an adjuvant treatment for acute bipolar depression: a Brazilian naturalistic study
Lamotrigine is indicated according to several recent treatment guidelines as a first-line medication for the treatment of bipolar depression. However, its efficacy in acute bipolar depression has not been well established. In the present naturalistic study, patients with bipolar depression (n = 20), predominantly bipolar type I, were treated with lamotrigine
Psychol. Neurosci.. Publicado em: 2013-06
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8. Coadministração lamotrigina e valproato de sódio em crianças e adolescentes com epilepsia refratária: estudo clínico / Lamotrigine and sodium valproate coadministration in children and adolescents with refractory epilepsy: clinical study
A associação de ácido valpróico/ divalproato de sódio e lamotrigina tem se mostrado eficaz no tratamento das epilepsias refratárias, tendo como limitador ao seu uso os efeitos adversos, principalmente numa população de crianças e adolescentes, onde esses efeitos são maximizados. Este estudo clínico tem como objetivo avaliar as propriedades farmaco
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/03/2012
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9. Interchangeability among therapeutic equivalents of lamotrigine: evaluation of quality of life
Epilepsia é o distúrbio neurológico grave mais comum no mundo todo. Aproximadamente 70% dos pacientes com epilepsia têm suas crises controladas com tratamento clínico e farmacológico. Esta pesquisa avaliou a possível interferência da intercambialidade entre equivalentes terapêuticos da lamotrigina na condição clínica e na qualidade de vida dos pa
Brazilian Journal of Pharmaceutical Sciences. Publicado em: 2012-03
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10. Development of a dissolution test for lamotrigine in tablet form using an ultraviolet method
A finalidade deste estudo foi desenvolver e validar um método de dissolução para o fármaco lamotrigina na forma farmacêutica comprimido. Este método também foi utilizado para comparar o perfil de dissolução entre o Neural® e o produto de referência Lamictal®. O procedimento analítico foi realizado utilizando-se espectrofotometria de absorção n
Brazilian Journal of Pharmaceutical Sciences. Publicado em: 2010-06
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11. Sensitive spectrophotometric determination of lamotrigine in bulk drug and pharmaceutical formulations using bromocresol green
Two new, simple, rapid and reproducible spectrophotometric methods have been developed for the determination of lamotrigine (LMT) both in pure form and in its tablets. The first method (method A) is based on the formation of a colored ion-pair complex (1:1 drug/dye) of LMT with bromocresol green (BCG) at pH 5.02±0.01 and extraction of the complex into dichl
Eclética Química. Publicado em: 2010
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12. Efeitos adversos tardios no uso de valproate e lamotrigina
Lamotrigina (LTG) é uma droga antiepiléptica bem tolerada com eficácia em diferentes formas de epilepsia, parcial e generalizada. Os efeitos adversos da lamotrigina estão freqüentemente associados com a sua introdução e a sua titulação. Este risco encontra-se aumentado em crianças e quando a LTG é usada em associação com o valproato. Nós relata
Journal of Epilepsy and Clinical Neurophysiology. Publicado em: 2007-12