Lasom 65
Mostrando 1-3 de 3 artigos, teses e dissertações.
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1. Bioanalytical method for the quantification of the monastrol derivative anticancer candidate lasom 65 in pre-clinical pharmacokinetic investigations
A simple HPLC/UV method was developed for the determination of the anticancer candidate LaSOM 65 in rat plasma. Samples were cleaned by protein precipitation with acetonitrile (recovery > 95%), after which they were subjected to chromatography under the isocratic elution of an acetonitrile:water (45:55, ν/ν) solution with detection at 303 nm. The method wa
Quím. Nova. Publicado em: 2014-06
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2. Avaliação pré-clínica da farmacocinética e da toxicidade aguda em roedores do candidato a fármaco antitumoral LaSOM 65 / Pre-clinical evaluation of the pharmacokinetics and acute toxicity in rodents of the anticancer candidate LaSOM 65
Objetivo: Contribuir para o desenvolvimento do candidato a antitumoral (LaSOM 65) através da avaliação farmacocinética pré-clínica em roedores de diferentes doses pelas vias i.v., p.o e i.p. e avaliação da toxicidade aguda do composto. Metodologia: LaSOM 65 foi administrado a ratos Wistar nas doses de 1 mg/kg i.v. bolus (n = 8), 10 e 30 mg/kg p.o. e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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3. Atividade anti-tumoral do composto LaSOM 65, derivado do monastrol, em linhagens de gliomas
Gliomas are the most common primary cancer in the central nervous system. Despite recent progress in the treatment of glioblastoma, the median survival of the patients still remains at 15 months. Kinesin Spindle Protein (KSP) has been reported as an interesting target for cancer therapy. Followed by the first specific KSP inhibitor, Monastrol, several other
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011