Ldlr Deficient
Mostrando 1-12 de 33 artigos, teses e dissertações.
-
1. Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties
Pequi is the fruit of Caryocar brasiliense and its oil has a high concentration of monounsaturated and saturated fatty acids, which are anti- and pro-atherogenic agents, respectively, and of carotenoids, which give it antioxidant properties. Our objective was to study the effect of the intake of a cholesterol-rich diet supplemented with pequi oil, compared t
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-07
-
2. Effect of citrate and Vimang TRADEMARK treatment on experimental atherosclerosis in hypercholesterolemic LDL receptor deficient mice / Efeito do tratamento com citrato e Vimang?MARCA REGISTRADA? sobre a aterosclerose experimental em camundongos hipercolesterolemicos deficientes de receptor de LDL
A aterosclerose é uma das principais doenças causadoras de morbidade e mortalidade nas populações ocidentais. Uma das teorias mais consistentes para explicar os mecanismos celulares e moleculares da aterogênese é a chamada "hipótese oxidativa", que aponta a oxidação da LDL como evento central na gênese e no desenvolvimento das lesões. Recentemente
Publicado em: 2009
-
3. Antibodies against electronegative LDL inhibit atherosclerosis in LDLr-/- mice
In order to determine the effect of antibodies against electronegative low-density lipoprotein LDL(-) on atherogenesis, five groups of LDL low receptor-deficient (LDLr-/-) mice (6 per group) were immunized with the following antibodies (100 µg each): mouse anti-LDL(-) monoclonal IgG2b, rabbit anti-LDL(-) polyclonal IgG or its Fab fragments and mouse irrelev
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-12
-
4. O papel do receptor toll-like 4 na aterogênese em modelo experimental de aterosclerose / Role of toll-like receptor 4 in atherogenesis in an experimental model of atherosclerosis
A crucial role has been suggested for toll-like receptor 4 (TLR4) in atherosclerotic plaque formation and development. TLR4 was described primarily, as a receptor for gram-negative bacteria lipopolisacharide; later it was showed that its expression is increased in atherosclerotic plaques and patients that carries a TLR4 dysfunctional polymorphism are less su
Publicado em: 2008
-
5. Avaliação da hiperhomocisteinemia leve na evolução da aterosclerose em camundongos normais, com hemofilia B, deficiencia dos receptores para LDL ou da apolipoproteina E / Evaluation of mild hyperhomocysteinemia in the development of atherosclerosis in normal, hemophiliac B, LDL receptor-deficient or apolipoprotein E-deficient mice
This study evaluated the effect of controlled mild hyperhomocysteinemia (HHcy) in the development of atherosclerosis using normal, apolipoprotein E-deficient (apoE-/-), LDL receptor-deficient (LDLR-/-), or hemophilia B mice. We quantified atherosclerotic lesions at the aortic sinus and analyzed endoplasmic reticulum (RE) stress by western-blot technique. Con
Publicado em: 2008
-
6. Anti-inflamatory effect of the S-nitroso-N-acetyleysteine (SNAC) on left ventricular hypertrophy in hypercholesterolemic LDLr/mice / Efeito antiinflamatorio da S-nitroso-N-acetilcisteina (SNAC) na hipertrofia ventricular esquerda (HVE) em camundongos hipercolesterolemicos knockout para o receptor de LDL (LDLr-/-)
Recently, it has been that S-nitroso-N-acetylcysteine (SNAC) attenuate in 55% the plaque development in low-density lipoprotein-receptor-deficient (LDLr-/-) mice fed a hypercholesterolemic diet for 15 days. The present study was designed to verify whether deletion of the low-density lipoprotein (LDL) receptor gene may affect the hemodynamic profile and adren
Publicado em: 2006
-
7. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor–deficient mice
Human atherosclerotic lesions overexpress the lysosomal cysteine protease cathepsin S (Cat S), one of the most potent mammalian elastases known. In contrast, atheromata have low levels of the endogenous Cat S inhibitor cystatin C compared with normal arteries, suggesting involvement of this protease in atherogenesis. The present study tested this hypothesis
American Society for Clinical Investigation.
-
8. The combined role of P- and E-selectins in atherosclerosis.
P- and E-selectins are adhesion molecules mediating the first step in leukocyte extravasation. Because their function in leukocyte adhesion is overlapping, we hypothesized that there might be a combined effect of these selectins on the development of atherosclerotic lesions. We bred P- and E-selectin-double-deficient mice onto the low-density lipoprotein rec
-
9. Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice.
The role of the low density lipoprotein receptor (LDLR) in the clearance of apo-B48-containing lipoproteins and the role of the LDLR-related protein (LRP) in the removal of apo-B100-containing lipoproteins have not been clearly defined. To address these issues, we characterized LDLR-deficient mice homozygous for an "apo-B48-only" allele, an "apo-B100-only" a
-
10. Hyperlipoproteinemia enhances susceptibility to acute disseminated Candida albicans infection in low-density-lipoprotein-receptor-deficient mice.
Recent studies have suggested the use of lipoproteins as an adjuvant treatment of lethal gram-negative infections. However, other important microorganisms for the etiology of sepsis, such as Candida species, grow better in lipid-rich environments. We investigated the effect of hyperlipoproteinemia on systemic candidiasis in low-density-lipoprotein-receptor-d
-
11. Dietary Fish Oil Exerts Hypolipidemic Effects in Lean and Insulin Sensitizing Effects in Obese LDLR−/− Mice1–3
Obesity is often associated with dyslipidemia, insulin resistance, and hypertension. Together, these metabolic perturbations greatly increase the risk of developing cardiovascular disease and diabetes. Although fish oil is a well-established hypolipidemic agent, the mechanisms by which it mediates its lipid-lowering effects are not clear. In addition, it has
American Society for Nutrition.
-
12. LDL receptor–related protein mediates cell-surface clustering and hepatic sequestration of chylomicron remnants in LDLR-deficient mice
It has been proposed that in the liver, chylomicron remnants (lipoproteins carrying dietary lipid) may be sequestered before being internalized by hepatocytes. To study this, chylomicron remnants labeled with a fluorescent dye were perfused into isolated livers of LDL receptor–deficient (LDLR-deficient) mice (Ldlr–/–) and examined by confocal microscop
American Society for Clinical Investigation.