Leishmania Pifanoi
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Fusão Homotípica e Heterotípica entre Vacúolos Parasitóforos de Leishmania spp / Homotypic and Heterotypic Fusion between Leishmania spp. Parasitophorous Vacuoles
Most non-viral intracellular pathogens gain entrance into human and animal host cells by classic or modifIed phagocytosis and are thus lodged in phagosomes which they may or not continue to occupy in the course of infection. Their survival and multiplication within host cells depend on modulation of the compositional and functional phenotypes of the phagosom
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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2. Characterization of the pre, pro and CTE domains of the cysteine proteinase 2 (Lpcys2) of Leishmania pifanoi: paper in lysosomal targeting and infection / Caracterização dos domínios pre-pro e C-terminal da cisteína proteinase Lpcys2 de Leishmania pifanoi: papel em endereçamento lisosomal e infecção
O objetivo do presente trabalho foi o estudo das características do domínio pre, pro e C-terminal da cisteína proteinase 2 (Lpcys2) de L. pifanoi e a relação destes domínios com endereçamento ao lisosomo e infecção. Na tentativa de identificar possíveis proteínas que se liguem ao sinal do domínio pro de Lpcys2, inicialmente usamos o sistema de do
Publicado em: 2006
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3. Leishmania pifanoi amastigote antigens protect mice against cutaneous leishmaniasis.
In the search for a leishmaniasis vaccine, extensive studies have been carried out with promastigote (insect stage) molecules. Information in this regard on amastigote (mammalian host stage) molecules is limited. To investigate host immune responses to Leishmania amastigote antigens, we purified three stage-specific antigens (A2, P4, and P8) from in vitro-cu
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4. Leishmania pifanoi Pathogenesis: Selective Lack of a Local Cutaneous Response in the Absence of Circulating Antibody
Recently, a role for B cells in the pathogenesis associated with infection by Leishmania (Leishmania mexicana complex and L. donovani) has been established. In the case of L. mexicana complex parasites (L. mexicana, L. pifanoi, and L. amazonensis), a critical role for immunoglobulin G-mediated mechanisms for the amastigote stage in the host is evident; howev
American Society for Microbiology.
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5. Biochemical and Biological Characterization of the Protective Leishmania pifanoi Amastigote Antigen P-8
The Leishmania pifanoi amastigote antigen P-8 has been previously shown to induce protective immunity in a murine model of cutaneous leishmaniasis (L. Soong, S. M. Duboise, P. Kima, and D. McMahon-Pratt, Infect. Immun. 63:3559–3566, 1995). As this antigen is of interest for further vaccine studies, the biochemical characterization of P-8 was undertaken. So
American Society for Microbiology.
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6. Leishmania pifanoi Amastigote Antigen P-4: Epitopes Involved in T-Cell Responsiveness in Human Cutaneous Leishmaniasis
In experimental murine cutaneous leishmaniasis, the purified Leishmania pifanoi amastigote protein P-4 has been shown to induce significant protection against infection. Further, recent studies examining the response of peripheral blood mononuclear cells (PBMC) from Leishmania braziliensis-infected human patients have demonstrated that the P-4 protein select
American Society for Microbiology.
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7. Upstream tRNA genes are essential for expression of small nuclear and cytoplasmic RNA genes in trypanosomes.
An interesting feature of trypanosome genome organization involves genes transcribed by RNA polymerase III. The U6 small nuclear RNA (snRNA), U-snRNA B (the U3 snRNA homolog), and 7SL RNA genes are closely linked with different, divergently oriented tRNA genes. To test the hypothesis that this association is of functional significance, we generated deletion
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8. DNA Immunization with the Gene Encoding P4 Nuclease of Leishmania amazonensis Protects Mice against Cutaneous Leishmaniasis
Infection with the protozoan parasite Leishmania amazonensis can cause diverse clinical forms of leishmaniasis. Immunization with purified P4 nuclease protein has been shown to elicit a protective response in mice challenged with L. amazonensis and L. pifanoi. To explore the potential of a DNA-based vaccine, we tested the L. amazonensis gene encoding P4 nucl
American Society for Microbiology.