Leishmanial Effect
Mostrando 1-12 de 28 artigos, teses e dissertações.
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1. Ascorbate peroxidase overexpression protects Leishmania braziliensis against trivalent antimony effects
Ascorbate peroxidase (APX) is a redox enzyme of the trypanothione pathway that converts hydrogen peroxide (H2O2) into water molecules. In the present study, the APX gene was overexpressed in Leishmania braziliensis to investigate its contribution to the trivalent antimony (SbIII)-resistance phenotype. Western blot results demonstrated that APX-overexpressing
Mem. Inst. Oswaldo Cruz. Publicado em: 14/11/2018
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2. Planejamento de inibidores das enzimas diidroorotato desidrogenase de Trypanosoma cruzi e Leishmania major / Design of inhibitors for dihydroorotate dehydrogenase from Trypanosoma cruzi and Leishmania major
Dihydroorotate dehydrogenase (DHODH) catalyses the conversion of dihydroorote to orotate, the fourth step and only redox reaction in the de novo pyrimidine biosynthetic pathway. DHODH has been exploited as a validated target for therapy against proliferative and parasitic diseases, and in particular, has been considered to be an attractive target for drug de
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/04/2012
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3. Avaliation of the vitro and in vivo antimalarial activity of violacein extrated from Chromobacteriuim violaceum / Avaliação in vivo e in vitro da atividade anti-plasmodial da violaceina extraida da Chromobacterium violaceum
Violacein is a violet pigment extracted from the bacteria Gram-negative Chromobacterium violaceum. Growing bodies of evidences have implicated violacein as an antimicrobial, antifungal, antitumoral, and a moderate trypanocidal and leishmanial activity has also been observed. Herein, we evaluated the anti-malarial activity of violacein against murine and huma
Publicado em: 2008
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4. x / Dinâmica de formação da reação inflamatória dérmica induzida pela Leishmania (Viannia) braziliensis no modelo primata Macaca mulatta.
The outcome of leishmanial infection of macrophages depends on factors particular to each host-parasite combination, involving not only intrinsic properties of the parasite, but also genetically determined characteristics of the host cell or of its interactions with immunocompetente cells. Human LTA caused by Leishmania (Viannia) braziliensis has a diversity
Publicado em: 2006
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5. Síntese e caracterização estrutural de N,N`-Diaribenzomidinas com atividade Leishmanicida
The synthesis of fourteen amidine derivatives of N,N-diarylbenzamidine class in the neutral and saline forms were realized by two methodologies. Basically, in both synthetical methods the same starting reagents were utilized, but involving a solid reaction and reflux conditions, respectively. The structural characterization was realized by spectroscopic tech
Publicado em: 2004
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6. Efeitos da hipoxia e do oxigenio hiperbarico nos modelos in vitro e in vivo da leishmaniose
Infections can cause the formation of hypoxic areas (low PO2). The altered blood flow, isquemia, cell proliferation and the presence of microorganisms causes hypoxia in injured tissues. Macrophages adapt to the presence of hypoxia and alter their metabolism, pro-inflammatory lymphokines production and phagocytosis activity. Lesions induced by Leishmania amaz
Publicado em: 2003
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7. Effect of barbatimão [Stryphnodendron adstringens (Mart.) Coville] infusion on the labling of blood elements with technetium-99m
The Barbatimão is a tree which bark is rich in tannin. It is used on popular medicine as a wound healing agent, in the treatment of gastric lesions, as anti-leishmanial agent and as anti-inflammatory. Red blood cells (RBC) are labeled with technetium-99m (Tc-99m) and are utilized in many procedures in nuclear medicine. Some authors have reported that drugs
Revista Brasileira de Farmacognosia. Publicado em: 2002
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8. Evaluation of leishmanicidal effects in vitro and in vivo of active chemical constiturnts derived of medicinal plants / AvaliaÃÃo do efeito leishmanicida in vitro e in vivo de constituÃntes quÃmicos ativos derivados de plantas medicinais
Antimonials, drugs of choice for the treatment of leishmaniasis, provide good results but have side effects and cases of resistance have been reported. In recent years, there has been an increase in the search for new antiparasitic drugs developed from plants extracts. This study aims to evaluate the leishmanicidal effects, both in vitro and in vivo, of two
Publicado em: 1999
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9. Effect of mitonafide analogs on topoisomerase II of Leishmania chagasi.
Mitonafide (4-nitro-benzoisoquinolinedione) and a number of structural analogs were synthesized and studied in order to determine the structural requirements for inhibition of leishmanial nuclear and kinetoplast topoisomerase II and human topoisomerase II. The structure-activity relationship studies with the mitonafide analogs demonstrated that there was sel
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10. Effect of visceral leishmaniasis on congenitally athymic mice.
Congenitally athymic mice were more susceptible to challenge with amastigotes of Leishmania donovani than were their thymus-intact littermates. This increased susceptibility correlated with a lack of Arthus and delayed-type responses when animals were skin tested with leishmanial antigen.
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11. Immunogenicity of soluble and particulate antigens from Leishmania donovani: effect of glucan as an adjuvant.
The protective efficacy of glucan as an adjuvant with killed promastigotes of Leishmania donovani was compared with that of soluble or particulate fractions of the parasite. When these vaccine preparations were injected either intravenously or subcutaneously in CF-1 mice, glucan potentiated resistance against L. donovani infections as reflected by significan
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12. Vaccination with Plasmid DNA Encoding TSA/LmSTI1 Leishmanial Fusion Proteins Confers Protection against Leishmania major Infection in Susceptible BALB/c Mice
We have recently shown that a cocktail containing two leishmanial recombinant antigens (LmSTI1 and TSA) and interleukin-12 (IL-12) as an adjuvant induces solid protection in both a murine and a nonhuman primate model of cutaneous leishmaniasis. However, because IL-12 is difficult to prepare, is expensive, and does not have the stability required for a vaccin
American Society for Microbiology.