Lethal Dosages
Mostrando 1-12 de 28 artigos, teses e dissertações.
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1. Evaluation of activity of synthetic chemical acaricides, botanical extract on Rhipicephalus sanguineus and action of essential oils on Amblyomma cajennense. / Avaliação da atividade de acaricidas químicos sintéticos, extrato botânico sobre Rhipicephalus sanguineus e ação dos óleos essenciais sobre Amblyomma cajennens.
Amblyomma cajennense (Fabricius, 1787) (Acari, Ixodidae) known as tick-star, is a ixodid heteroxenous tree-host found too often in horses. Have little specific parasite, particularly in periods of larvae and nymph, is considered the most important in ixodid transmission of spotted fever to humans in Brazil. Rhipicephalus sanguineus, tick ectoparasite mainly
Publicado em: 2008
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2. Evaluation of activity of synthetic chemical acaricides, botanical extract on Rhipicephalus sanguineus and action of essential oils on Amblyomma cajennense. / Avaliação da atividade de acaricidas químicos sintéticos, extrato botânico sobre Rhipicephalus sanguineus e ação dos óleos essenciais sobre Amblyomma cajennens.
Amblyomma cajennense (Fabricius, 1787) (Acari, Ixodidae) known as tick-star, is a ixodid heteroxenous tree-host found too often in horses. Have little specific parasite, particularly in periods of larvae and nymph, is considered the most important in ixodid transmission of spotted fever to humans in Brazil. Rhipicephalus sanguineus, tick ectoparasite mainly
Publicado em: 2008
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3. ESTUDO DA ECOLOGIA DE INFECÇÃO DOS NEMATÓIDES ENTOMOPATOGÊNICOS Heterorhabditis riobravus e Steinernema carpocapsae (RHABDITIDA: HETERORHABDITIDAE, STEINERNEMATIDAE) EM Alphitobius diaperinus (COLEOPTERA: TENEBRIONIDAE)
Aphitobius diaperinus (Panzer), known as cascudinho or "lesser mealworm" colonizes the substrate found at farms, developing itselves in high populations, causing sanitary and economical problems. They affect the health and performance of the birds, being also transmitters of diseases. Their control is based on the application of insecticides, which increase
Publicado em: 2006
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4. Detecção e efeito de drogas no crescimento e desenvolvimento de formas imaturas e adultas de Chrysomya Albiceps (Wiedemann) e Chrysomia Putoria (Wiedemann) (Diptera: Calliphoridae), duas moscas varejeiras de interesse forense
The toxicological analysis of biological samples such as imature stages and adults of insects can contribute to criminal investigations to improve the estimate the post mortem interval and to determine the absence or presence of a drug in the corpse. Two blow fly species: Chrysomya albiceps (Wiedemann) and Chrysomya putoria (Wiedemann) (Diptera: Calliphorida
Publicado em: 2005
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5. Evaluation of Various Analogues of Tilorone Hydrochloride Against Venezuelan Equine Encephalitis Virus in Mice
The antiviral activity of tilorone hydrochloride and three of its analogues (11,002, 11,567, and 11,877) was assessed by oral and intraperitoneal (i.p.) administration to Venezuelan equine encephalitis (VEE) virus-infected mice. Significant increases in the percentage of survival (P < 0.01) were apparent after oral administration of tilorone and analogue 11,
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6. Endotoxin toxicity in rats with 6-sulfanilamidoindazole arthritis.
Seven oral administrations of 6-sulfanilamidoindazole (6-SAI) to 10- to 12-month-old rats sensitized the animals to endotoxin, with dosages as small as 2.5 microgram causing death in 80% of animals. Endotoxin in a dosage of 3,000 microgram was not lethal for nonmedicated control animals. 6-SAI-treated 1-month-old rats were not as sensitive to endotoxin as ag
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7. Efficacy and safety of amphotericin B colloidal dispersion compared with those of amphotericin B deoxycholate suspension for treatment of disseminated murine cryptococcosis.
The efficacy and safety of amphotericin B colloidal dispersion (ABCD) were compared with those of amphotericin B deoxycholate suspension (ABDS) (Fungizone) in a murine model of disseminated cryptococcosis. Mice were treated intravenously with either ABDS at 0.2, 0.8, or 3.2 mg/kg of body weight per dose or ABCD at 0.8, 3.2, 6.4, 12.8, or 19.2 mg/kg dose thre
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8. Prophylactic administration of interleukin-2 protects mice from lethal challenge with gram-negative bacteria.
Prophylactic administration of recombinant human interleukin-2 (IL-2) in mice enhanced survival and produced complete recovery from an otherwise lethal acute bacterial infection. IL-2 was administered as a single intraperitoneal or intravenous bolus dose to CDI mice 18 h before challenge with a lethal dose of a clinical isolate of Escherichia coli type O2 (m
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9. Mutagenesis in CAENORHABDITIS ELEGANS. II. a Spectrum of Mutational Events Induced with 1500 R of γ-RADIATION
We previously established a γ-ray dose-response curve for recessive lethal events (lethals) captured over the eT1 balancer. In this paper we analyze the nature of lethal events produced, with a frequency of 0.04 per eT1 region, at a dose of 1500 r. To do so, we developed a protocol that, in the absence of cytogenetics, allows balanced lethals to be analyzed
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10. Toxicity of LY303366, an Echinocandin Antifungal, in Mice Pretreated with Glucocorticoids
LY303366 is a semisynthetic derivative of the echinocandin class. During preclinical studies, lethal toxicity was observed in DBA/2 mice pretreated with a cortisone acetate dose followed by treatment with LY303366 at doses ranging from 12.5 to 50 mg/kg of body weight/day given intraperitoneally (i.p.). In the cortisone-treated, uninfected controls, 90% given
American Society for Microbiology.
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11. Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell–mediated graft-versus-host disease model
Minor histocompatibility antigens with expression restricted to the recipient hematopoietic compartment represent prospective immunological targets for graft-versus-leukemia therapy. It remains unclear, however, whether donor T cell recognition of these hematopoietically derived minor histocompatibility antigens will induce significant graft-versus-host dise
American Society for Clinical Investigation.
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12. Efficacy of SCH 39304 in treatment of experimental invasive aspergillosis.
The efficacy of SCH 39304 (SCH) against Aspergillus fumigatus was assessed with an immunosuppressed, temporarily leukopenic rabbit model of invasive aspergillosis. Therapy with SCH at 10 or 15 mg/kg of body weight per day was begun 24 h after lethal challenge and compared with therapy with amphotericin B at 1.5 mg/kg/day. Compared with untreated controls, SC