Leukotriene B4
Mostrando 1-12 de 223 artigos, teses e dissertações.
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1. Leukotriene B4 Loaded in Microspheres Inhibits Osteoclast Differentiation and Activation
Resumo O objetivo deste trabalho foi Investigar a formação de osteoclastos in vivo e se o leucotrieno B4 (LTB4) incorporado em microesferas (MS) poderia ser usado como estratégia terapêutica para promover uma entrega sustentada do mediador e prevenir a diferenciação dos osteoclastos. Métodos: In vivo, a periodontite apical foi induzida em camundongos
Brazilian Dental Journal. Publicado em: 2022
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2. Leukotriene B4 in equine asthma syndrome: what do we know so far?
RESUMO: Recentemente, o termo “síndrome da asma equina” (SAE) foi proposto devido à semelhança da doença equina à asma humana. Os leucotrienos causam constrição dos brônquios, especialmente nas vias aéreas posteriores e aumentam a secreção de muco no sistema respiratório. O leucotrieno B4 (LTB4) foi descoberto como um forte fator quimiotátic
Pesq. Vet. Bras.. Publicado em: 04/11/2019
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3. Estudo da ativação eosinofílica e de matriz extracelular de tecido pulmonar periférico em cobaias com inflamação alérgica pulmonar: efeitos do tratamento com dexametasona e antagonista do receptor do cisteinil-leucotrieno D4
Aims: Compare the effects of montelukast or dexamethasone treatments on eosinophilic recruitment, eotaxin, RANTES, fibronectin, IGF-I and NF-B positive cells of distal lung parenchyma and also in airway walls of guinea pigs (GP) with chronic allergic inflammation. Methods: GP were inhaled with ovalbumin (OVA group-2x/week/4weeks). After 4th inhalation, GP we
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/08/2012
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4. Evidence for eosinophil recruitment, leukotriene B4 production and mast cell hyperplasia following Toxocara canis infection in rats
It is well known that eosinophilia is a key pathogenetic component of toxocariasis. The objective of the present study was to determine if there is an association between peritoneal and blood eosinophil influx, mast cell hyperplasia and leukotriene B4 (LTB4) production after Toxocara canis infection. Oral inoculation of 56-day-old Wistar rats (N = 5-7 per gr
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-04
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5. Atividades in vitro e in vivo de microesferas biodegradáveis contendo leucotrieno B4 e/ou antígenos livres de células de Histoplasma capsulatum / In vitro and in vivo activities of biodegradable microspheres containing leukotriene B4 and/or cell-free antigens from Histoplasma capsulatum
O Histoplasma capsulatum é um fungo dimórfico responsável por infecções pulmonares graves caracterizadas por reação granulomatosa. Sua incidência vem aumentando nos últimos anos devido principalmente às alterações imunológicas relacionadas ao comprometimento da imunidade celular. Anteriormente, nosso grupo de pesquisa demonstrou o envolvimento d
Publicado em: 2010
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6. Componentes da resposta inflamatória aguda que favorecem a progressão do melanoma e, modelo murino. / Components of the acute inflammatory response that promote the progression of melanoma in a murine model
Chronic inflammation is one of the main factors that predispose to cancer development and contribute to tumor progression. However, some studies show that acute inflammation is also able to generate a microenvironment favorable to the growth of certain tumors. In our laboratory, Correa et al. showed that injection of a large amount of apoptotic cells creates
Publicado em: 2009
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7. Role of leukotrienes in immune protection conferred by the heterologous immunization BCG/DNA-HSP65 against tuberculosis / Papel dos leucotrienos na proteção conferida pela imunização heteróloga BCG/DNA-HSP65 contra tuberculose
Tuberculosis is responsible for more than 2 millions of death for year. The immune response against tuberculosis is related to activation of IFN-g-producing CD4+ and CD8+ cells. IFN-g increases the microbicidal mechanisms of macrophages to kill intracellular bacilli. Recently, the lipid mediator leukotriene B4 (LTB4) has been related to protection against se
Publicado em: 2009
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8. Studies about the effects of the in vivo administration of Leukotriene B4 or Prostaglandin E2-loaded biodegradable microspheres on model of murine histoplasmosis / Estudos sobre os efeitos da administração in vivo de microesferas biodegradáveis contendo Leucotrieno B4 ou Prostaglandina E2 em modelo de histoplasmose murina
Leukotrienes and prostaglandins are arachidonic acid metabolites, which participate in the inflammatory response and modulate cytokines release in both adaptive and innate immune responses. However, some physicochemical characteristics of these mediators, such as poor solubility in water and chemical instability, make them difficult to administer in vivo. In
Publicado em: 2008
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9. The supplementation with fatty poliinsaturated omega-3 acids reduced the plasmatic concentration of pro-inflammatory eicosanoids of the lactate desidrogenase enzyme and muscular lesions in rats submitted to sessions of swimming. / A suplementação com acidos graxos polinsaturados omega-3 reduziu a concentração plasmatica de eicosanoides pro-inflamatorios, da enzima lactato desidrogenase e de lesões musculares em ratos submetidos a sessões de natação.
The use of antiinflammatory drugs is common among athletes in which the prevalence of muscular lesions is elevated in training and competition periods. However, some of those drugs have an immunosuppression action, and when used in high dosages or for long time can provoke a decrease in the immunological responses. The objective of the present Thesis was to
Publicado em: 2007
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10. Study of participation of nitric oxide about acute cellular migration in the arthritis and peritonitis induced by zymosan or lipopolysaccharide in experimental models / Estudo da participação do óxido nítrico na migração celular aguda na artrite e peritonite induzidas por zymosan ou lipopolissacarídeo em modelos experimentais
Cell influx (CI) to synovium participates in physiopathology of rheumatoid arthritis (RA). There are controversies about the nitric oxide (NO) action in modulation of neutrophil influx to inflammatory sites, with NO decreasing or increasing it. This study investigated the effect of nitric oxide synthase (NOS) inhibitors on acute CI in animals submitted to ar
Publicado em: 2005
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11. Erythrocyte-neutrophil interactions: formation of leukotriene B4 by transcellular biosynthesis.
Studies on the mechanism of leukotriene B4 biosynthesis in suspensions composed of neutrophils plus erythrocytes indicate that human erythrocytes convert neutrophil-derived leukotriene A4 into leukotriene B4. Leukotriene B4 formation by neutrophils in the presence of erythrocytes exceeded that from corresponding suspensions of neutrophils alone. The increase
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12. Leukotriene B4 Augments Neutrophil Phagocytosis of Klebsiella pneumoniae
Neutrophils play a critical role in the clearance of bacteria from the lung and other organs by their capacity for phagocytosis and killing. Previously, we identified an important role for the leukotrienes in rat alveolar macrophage phagocytosis of Klebsiella pneumoniae. In this report, we explored the possibility that the leukotrienes play an important role
American Society for Microbiology.