Lever Mechanism
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Dispositivo automático para auxiliar a manipulação de cargas. / Automatic device to assist the handling materials.
The material handling is one task in which robot is commonly employed to replace the human work because it has some advantages such as, higher precision in the handling and higher speed of the task, and to increase operator safety. Despite these advantages, the robotic device is most employed only in situation that speed and precision are essential; in other
Publicado em: 2009
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2. A monomeric myosin VI with a large working stroke
Myosin VI is involved in a wide variety of intracellular processes such as endocytosis, secretion and cell migration. Unlike almost all other myosins so far studied, it moves towards the minus end of actin filaments and is therefore likely to have unique cellular properties. However, its mechanism of force production and movement is not understood. Under our
Nature Publishing Group.
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3. Myosin VI is a processive motor with a large step size
Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. To carry out its cellular functions myosin VI moves toward the pointed end of actin, backward in relation to all other characterized myosins. Myosin V, a motor that moves toward the barbed end of actin, is processive, undergoing multiple catalytic cycles and mechanical
The National Academy of Sciences.
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4. Intrinsic flexibility and gating mechanism of the potassium channel KcsA
The gating mechanism of the potassium channel KcsA was studied by normal mode analysis. The results provided an atomic description of the locations of the pivot points and the motional features of key structural elements in the gating process. Two pivot points were found in the motions of the inner TM2 helical bundle that directly modulate the size of the ce
The National Academy of Sciences.
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5. Structure and orientation of lung surfactant SP-C and L-alpha-dipalmitoylphosphatidylcholine in aqueous monolayers.
SP-C, a pulmonary surfactant-specific protein, aids the spreading of the main surfactant phospholipid L-alpha-dipalmitoylphosphatidylcholine (DPPC) across air/water interfaces, a process that has possible implications for in vivo function. To understand the molecular mechanism of this process, we have used external infrared reflection-absorption spectroscopy
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6. Reversal of the Myosin Power Stroke Induced by Fast Stretching of Intact Skeletal Muscle Fibers
Force generation and movement in skeletal muscle result from a cyclical interaction of overlapping myosin and actin filaments that permits the free energy of ATP hydrolysis to be converted into mechanical work. The rapid force recovery that occurs after a step release imposed on a muscle is thought to result from a synchronized tilting of myosin lever arms t
The Biophysical Society.
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7. The αβ T Cell Receptor Is an Anisotropic Mechanosensor*
Thymus-derived lymphocytes protect mammalian hosts against virus- or cancer-related cellular alterations through immune surveillance, eliminating diseased cells. In this process, T cell receptors (TCRs) mediate both recognition and T cell activation via their dimeric αβ, CD3ϵγ, CD3ϵδ, and CD3ζζ subunits using an unknown structural mechanism. Here, si
American Society for Biochemistry and Molecular Biology.
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8. Relationship between nucleotide binding and ion channel gating in cystic fibrosis transmembrane conductance regulator
We have employed rate-equilibrium free energy relationship (REFER) analysis to characterize the dynamic events involved in the allosteric regulation of cystic fibrosis transmembrane conductance regulator (CFTR) function. A wide range of different hydrolysable and poorly hydrolysable nucleoside triphosphates were used to elucidate the role of ATP hydrolysis i
Blackwell Science Inc.
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9. Response-reinforcement learning is dependent on N-methyl-d-aspartate receptor activation in the nucleus accumbens core
The nucleus accumbens, a site within the ventral striatum, is best known for its prominent role in mediating the reinforcing effects of drugs of abuse such as cocaine, alcohol, and nicotine. Indeed, it is generally believed that this structure subserves motivated behaviors, such as feeding, drinking, sexual behavior, and exploratory locomotion, which are eli
The National Academy of Sciences of the USA.
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10. Mutant G protein α subunit activated by Gβγ: A model for receptor activation?
How receptors catalyze exchange of GTP for GDP bound to the Gα subunit of trimeric G proteins is not known. One proposal is that the receptor uses the G protein's βγ heterodimer as a lever, tilting it to pull open the guanine nucleotide binding pocket of Gα. To test this possibility, we designed a mutant Gα that would bind to βγ in the tilted con
The National Academy of Sciences.