Lipid Dispersions
Mostrando 1-12 de 49 artigos, teses e dissertações.
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1. Effect of different stress conditions on the stability of quercetin-loaded lipid microparticles produced with babacu ( Orbignya speciosa ) oil: evaluation of their potential use in food applications
Lipid micro and nanoparticles have been extensively investigated as carriers for hydrophobic bioactives in food systems because they can simultaneously increase the dispersibility of these lipophilic substances and help improve their bioavailability. In this study, lipid microparticles of babacu oil and denatured whey protein isolate were produced, and their
Food Sci. Technol. Publicado em: 05/02/2016
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2. Comparative study of sustained-release lipid microparticles and solid dispersions containing ibuprofen
O ibuprofeno é um dos antiinflamatórios não esteróides mais utilizados no tratamento de patologias associadas a processos inflamatórios. Este fármaco, quando no seu estado puro, apresenta características físicas e mecânicas pouco satisfatórias e a sua utilização em formas sólidas só é possível se forem adicionados excipientes que permitam mel
Braz. J. Pharm. Sci.. Publicado em: 2012-09
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3. Nanoemulsões como sistemas de liberação parenteral de fármacos
Lipid nanoemulsions have recently been proposed as parenteral delivery systems for poorly-soluble drugs. These systems consist of nanoscale oil/water dispersions stabilized by an appropriate surfactant system in which the drug is incorporated into the oil core and/or adsorbed at the interface. This article reviews technological aspects of such nanosystems, i
Quím. Nova. Publicado em: 2012
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4. Preparação e caracterização de suspensões coloidais de nanocarreadores lipídicos contendo resveratrol destinados à administração cutânea
Solid lipid nanoparticles (SLN), nanoemulsions (NE), and microemulsions (ME) were prepared by the hot solvent diffusion method, using tristearin or castor oil as oily phase, and soy lecithin and Solutol HS 15 as surfactants. Mean particle sizes ranged from 20 to 215 nm and negative zeta potentials were obtained for all nanocarriers. A HPLC method used to det
Química Nova. Publicado em: 2011
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5. Dispersões lipídicas de dimiristoil fosfatidilglicerol: um estudo termo-estrutural / Lipid dispersions of dymiristoyl phosphatidylglycerol: a thermo-structural study
Dispersions of the saturated anionic phospholipid dimyristoyl phosphatidyl glycerol (DMPG) have been extensively studied regarding their peculiar thermo-structural behavior. At low ionic strength, the gel-fluid transition is spread along nearly 17 ºC, displaying several thermal events in the calorimetric profile, quite different from the single sharp peak a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/12/2010
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6. Caracterização estrutural de agregados formados pelo antifúngico anfotericina B e lipídios catiônicos: uma possível formulação farmacológica / Structural characterization of aggregates formed by the antifungal drug amphotericin B and cationic lipids: a possible pharmacological formulation
Amphotericin B (AB) is a natural antibiotic, produced by Streptomyces nodosus, with a very potent antifungal activity. It is a polyene macrolide molecule, isolated in 1953. Since then, it has been extensively used in the treatment of systemic mycotic infections. Considering AB very low solubility in aqueous medium, it has been largely used as an aqueous disp
Publicado em: 2008
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7. Dipropionato de beclometasona em formulação lipossomal como po inalavel para o tratamento de doenças pulmonares
The liposomal drug encapsulation for medical applications is in many instances the most efficient way to ensure good storage, transport, targeting, and controlled release of the drug, thus reducing toxicity. Liposomes have been extensively studied as vehicles for efficient drug delivery. The objective of the present work is to develop a formulation of the co
Publicado em: 2007
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8. Rheology and transition shapes of elastic liposomes in nanopores membranes / Reologia e transição de formas de lipossomas elasticos em membranas de nanoporos
In this work, liposomes prepared with comercial egg lecithin and octaoxyethylenelaurate-ester (PEG-8L) were characterized and studied in respect to PEG-8L incorporation, shape transitions, elasticity and rheology in nanopores membranes. Conventional liposomes (without PEG-8L) were used as control. The concentrated caffeine, extracted of guarana seeds, was in
Publicado em: 2007
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9. Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique
The basic objectives of this study were to prepare and characterize solid dispersions of poorly water-soluble drug etoricoxib using lipid carriers by spray drying technique. The properties of solid dispersions were studied by diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), differential scanning calorimetry (DSC), hotstage microscopy (HS
Springer-Verlag.
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10. Surfactant protein B: lipid interactions of synthetic peptides representing the amino-terminal amphipathic domain.
The mechanisms by which pulmonary surfactant protein B (SP-B) affects the surface activity of surfactant lipids are unclear. We have studied the peptide/lipid interactions of the amino-terminal amphipathic domain of SP-B by comparing the secondary conformations and surface activities of a family of synthetic peptides based on the native human SP-B sequence,
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11. Cellular cholesterol ester accumulation induced by free cholesterol-rich lipid dispersions.
The influence of lipoprotein composition on free cholesterol (RC) esterification and accumulation of esterified cholesterol (EC) was studied in cells of Fu5AH rat hepatoma exposed to culture media supplemented with (FC/P) ranging from 0.6 to 2.8. In the presence of normal human serum, FC-lecithin dispersions witb a FC/P greater than one stimulated both the e
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12. Modification of red cell membrane structure by cholesterol-rich lipid dispersions. A model for the primary spur cell defect.
Cholesterol-rich membranes are the hallmark of "spur" red cells. Spur cells accumulate cholesterol from cholesterol-rich serum lipoproteins. Previous studies suggested that this added cholesterol is responsible for both the altered morphology and the destruction of spur cells. To examine this process in the absence of other serum factors, cholesterol-lecithi