Lipofuscin Granules
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Estudo dos grânulos de lipofucsina e das sinapses do córtex temporal durante o envelhecimento / Study of lipofuscin granules and synapses in the temporal cortex during aging.
Alterações morfológicas e funcionais ocorrem durante o envelhecimento, período da vida com maior incidência de doenças neurodegenerativas. No presente trabalho acompanhou-se a evolução dos grânulos de lipofucsina durante o envelhecimento para investigar alterações sinápticas, assim como proteínas associadas com doenças neurodegenerativas (alfa-
Publicado em: 2011
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2. Spectroscopic and morphological studies of human retinal lipofuscin granules
The emission properties of ocular lipofuscin granules isolated from human retinal pigment epithelial cells are examined by using steady-state fluorescence spectroscopy and spectrally resolved confocal microscopy. The shape of the emission spectrum of a thick sample of lipofuscin granules dried on glass varies with excitation energy. The polarization of this
The National Academy of Sciences.
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3. Ultrastructural changes of posterior lingual glands after hypoglossal denervation in hamsters
Posterior lingual glands consist of two sets of minor salivary glands that serve important functions in oral physiology. To investigate the hypothesis that the hypoglossal nerve provides sympathetic innervation to the posterior lingual glands, we examined ultrastructural changes in the glands following hypoglossal denervation. In the posterior deep lingual g
Blackwell Science Inc.
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4. Lipofuscin and melanin content of the retinal pigment epithelium in a case of Sjögren-Larsson syndrome.
Necropsy material from the eye of a 23-year-old male known to have suffered from the Sjögren-Larsson syndrome, characterised by mental retardation, spastic diplegia or tetraplegia, congenital ichthyosis, and so-called glistening dots in the foveal and parafoveal areas of the fundus of the eye, was investigated ultrastructurally. The retinal pigment epitheli
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5. Portal lymphadenopathy associated with lipofuscin in chronic cholestatic liver disease.
To determine whether portal lymphadenopathy in primary biliary cirrhosis is caused by deposition of lipofuscin pigment in sinus histiocytes and to compare primary biliary cirrhosis with other liver diseases a retrospective study on a consecutive series of 169 livers obtained at transplantation was carried out. There were grouped into eight diagnostic categor
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6. Histological and ultrastructural evaluation of cardiac lesions in idiopathic cardiomyopathy in dogs.
Described are pathological studies of eight dogs which died in congestive heart failure, with a clinical diagnosis of congestive cardiomyopathy. Examination revealed marked dilatation and enlargement of all four chambers of the heart. The ventricular walls were thin with small atrophic papillary muscles. Histological studies on the myocardium revealed scatte
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7. Post-traumatic hyperlipofuscinosis in the human retinal pigment epithelium.
Light microscopy (including fluorescence microscopy) and electron microscopy were applied to a study of the photoreceptor-retinal pigment epithelium (RPE) complex in a human eye which had been severely traumatised nine months prior to enucleation. The main feature of interest was a massive accumulation of lipofuscin in the retinal pigment epithelium at the p
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8. Structural characterization and immunochemical detection of a fluorophore derived from 4-hydroxy-2-nonenal and lysine
Aging and the progression of certain degenerative diseases are accompanied by increases in intracellular fluorescent material, termed “lipofuscin” and ceroid, respectively. These pigments are observed within granules composed, in part, of damaged protein and lipid. Modification of various biomolecules by aldehyde products of lipid peroxidation is believe
The National Academy of Sciences.
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9. Ultrastructure of the pineal gland in the adult rat.
The ultrastructure of the rat pineal gland was studied from 75 days until 10 months of age. Type I pinealocytes of young adults showed nuclei with dispersed chromatin, numerous infoldings of the nuclear envelope and well developed nucleoli. The cytoplasm displayed many mitochondria and clusters of smooth endoplasmic reticulum. With increasing age, there was
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10. Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease.
beta-Amyloid formation requires multiple abnormal proteolytic cleavages of amyloid precursor protein (APP), including one within its intramembrane domain. Lysosomes, which contain a wide variety of proteases (cathepsins) and other acid hydrolases, are major sites for the turnover of membrane proteins and other cell constituents. Using immunocytochemistry, im
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11. Ultrastructure of Leydig cells in human ageing testes.
Ultrastructural study of Leydig cells in elderly men revealed the following Leydig cell types: (1) ultrastructurally normal Leydig cells (46.2%); (2) Leydig cells either with multiple cytoplasmic or intranuclear Reinke crystals or with numerous para-crystalline inclusions (6.1%); (3) multivacuolated Leydig cells with the cytoplasm almost filled by lipid drop
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12. The ultrastructure of the sensory end-organs (baroreceptors) in the atrial endocardium of young mini-pigs.
Light and electron microscopical studies on pig hearts have confirmed the presence in the right and the left atrial endocardium of distinct circumscribed, unencapsulated end-organs (baroreceptors) associated with 4-9 mum thick nerve fibres. The myelin sheath terminates before the entrance of the nerve into the end-organ. The regular presence of thin axon pro