Lipotoxicity
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. AKT inhibitor suppresses hyperthermia-induced Ndrg2 phosphorylation in gastric cancer cells
Hyperthermia is one of the most effective adjuvant treatments for various cancers with few side effects. However, the underlying molecular mechanisms still are not known. N-myc downstream-regulated gene 2 (NDRG2), a tumor suppressor, has been shown to be involved in diverse cellular stresses including hypoxia, lipotoxicity, etc. In addition, Ndrg2 has been r
Braz J Med Biol Res. Publicado em: 05/04/2013
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2. O efeito pró-apoptótico de oligômeros da amilina humana não é potencializado pela lipotoxicidade em ilhotas pancreáticas de rato em cultura / The pro-apoptotic effect of human amylin oligomers is not potentiated by lipotoxicity in rat pancreatic islets in culture
The amyloid deposit is a common histopathological feature in patients with type 2 diabetes mellitus (T2DM) and it seems to be related to the pancreatic beta cell dysfunction characteristic of this disease. A study previously developed in our laboratory found that human amylin oligomers decrease mRNA expression of the glucose-dependent insulinotropic polypept
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/07/2012
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3. Efeito in vivo e in vitro do guaraná nos distúrbios metabólicos e nos biomarcadores inflamatórios associados à lipotoxicidade / The In vivo and in vitro effect of guaraná on metabolic diseases and inflammatory markers associated to lipotoxicity
A prevalência mundial da obesidade tem aumentado consideravelmente, nas últimas décadas. Os indivíduos obesos apresentam riscos de desenvolvimento de resistência à insulina, diabetes tipo 2, dislipidemia, doenças cardiovasculares, síndrome metabólica (SM) e câncer. Além disso, a obesidade tem sido relacionada a alterações oxidativas e a uma infl
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/03/2012
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4. ASSOCIAÇÃO ENTRE O POLIMORFISMO +3954 DO GENE DA INTERLEUCINA-1 BETA, OBESIDADE, LDL-OXIDADO E SEU POTENCIAL EFEITO LIPOTÓXICO / ASSOCIATION BETWEEN INTERLEUKIN-1 BETA GENE, OBESITY, LDL-OXIDADE AND ITS LIPOTOXICITY EFFECT POTENCIAL
A obesidade é um inflamação sistêmica de baixo grau associado a elevada liberação de moléculas pró-inflamatórias pelo tecido adiposo. O aumento da adiposidade resulta em necrose tecidual e liberação de ácidos graxos, a partir dos adipócitos, que tendem a se acumular em outros tecidos corporais causando um fenômeno conhecido como lipotoxicidade.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/03/2012
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5. Lipotoxicidade na leptospirose humana: aspectos prognósticos e potencial efeito benéfico da administração de albumina / Lipotoxicity in human leptospirosis: prognostic aspects and potental beneficial effect of albumin administration
A leptospirose humana é uma doença infecciosa aguda de amplo espectro clínico e que cursa com alterações metabólicas e dislipidêmicas envolvendo colesterol total e frações, triglicerídeos e ácidos graxos não esterificados (AGNEs). Dentre os mecanismos celulares envolvidos na sua fisiopatologia encontram-se a inibição da enzima Na, K ATPase pela
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/04/2011
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6. Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Excess lipid accumulation in non-adipose tissues is associated with insulin resistance, pancreatic β-cell apoptosis and heart failure. Here, we demonstrate in cultured cells that the relative toxicity of two common dietary long chain fatty acids is related to channeling of these lipids to distinct cellular metabolic fates. Oleic acid supplementation leads t
The National Academy of Sciences.
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7. Myocardial lipid accumulation and lipotoxicity in heart failure1
The American Society for Biochemistry and Molecular Biology.
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8. Skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes
Blackwell Science Inc.
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9. Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice
The physiologic function of the progressive hyperleptinemia of diet-induced obesity is unknown. However, that lipotoxicity in nonadipose tissues of congenitally unleptinized obese rodents is far greater than in hyperleptinemic diet-induced obesity rodents has suggested an antilipotoxic role. To test this hypothesis, mice with severe lipotoxic cardiomyopathy,
National Academy of Sciences.
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10. Perilipin Is Present in Islets of Langerhans and Protects against Lipotoxicity When Overexpressed in the β-Cell Line INS-1
Lipids have been shown to play a dual role in pancreatic β-cells: a lipid-derived signal appears to be necessary for glucose-stimulated insulin secretion, whereas lipid accumulation causes impaired insulin secretion and apoptosis. The ability of the protein perilipin to regulate lipolysis prompted an investigation of the presence of perilipin in the islets
The Endocrine Society.
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11. Sterol and Diacylglycerol Acyltransferase Deficiency Triggers Fatty Acid-mediated Cell Death*
Deletion of the acyltransferases responsible for triglyceride and steryl ester synthesis in Saccharomyces cerevisiae serves as a genetic model of diseases where lipid overload is a component. The yeast mutants lack detectable neutral lipids and cytoplasmic lipid droplets and are strikingly sensitive to unsaturated fatty acids. Expression of human diacylglyce
American Society for Biochemistry and Molecular Biology.
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12. Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats
To determine whether the antidiabetic action of troglitazone (TGZ), heretofore attributed to insulin sensitization, also involves protection of β cells from lipoapoptosis, we treated prediabetic Zucker Diabetic Fatty rats with 200 mg/kg per day of TGZ. Their plasma-free fatty acids and triacylglycerol fell to 1.3 mM and 111 mg/dl, respectively, compared wit
The National Academy of Sciences.