Liver Fibrogenesis
Mostrando 1-12 de 46 artigos, teses e dissertações.
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1. Candesartan, rather than losartan, improves motor dysfunction in thioacetamide-induced chronic liver failure in rats
Minimal hepatic encephalopathy is more common than the acute syndrome. Losartan, the first angiotensin-II receptor blocker (ARB), and candesartan, another widely-used ARB, have protected against developing fibrogenesis, but there is no clear data about their curative antifibrotic effects. The current study was designed to examine their effects in an already-
Braz J Med Biol Res. Publicado em: 21/09/2017
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2. Dynamic expression of desmin, α-SMA and TGF-β1 during hepatic fibrogenesis induced by selective bile duct ligation in young rats
We previously described a selective bile duct ligation model to elucidate the process of hepatic fibrogenesis in children with biliary atresia or intrahepatic biliary stenosis. Using this model, we identified changes in the expression of alpha smooth muscle actin (α-SMA) both in the obstructed parenchyma and in the hepatic parenchyma adjacent to the obstruc
Braz J Med Biol Res. Publicado em: 15/08/2014
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3. Efeito do Ácido Gálico sobre a fibrogênese hepática murina / Effect of Gallic Acid in murine hepatic fibrogenesis
The fibrogenic processes activate by mechanisms such as oxidative stress can lead to a picture of liver cirrhosis, which represents a major cause of death in West. However, in some studies, phenolic substances, such as Gallic Acid (GA) shown to inhibit and even regress theses processes. The aim of this study was to investigate the effects of the phenolic com
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/04/2012
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4. Effects of the administration of pentoxifylline and prednisolone on the evolution of portal fibrogenesis secondary to biliary obstruction in growing animals: immunohistochemical analysis of the expression of TGF-β and VEGF
OBJECTIVE: During the neonatal and infancy periods, some chronic liver diseases may lead to progressive hepatic fibrosis, which is a condition that can ultimately result in the loss of organ function and severe portal hypertension necessitating hepatic transplantation. In a previous report, pharmacological interventions were demonstrated to modulate hepatic
Clinics. Publicado em: 2012-12
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5. Participação das conexinas 43 e 32 no desenvolvimento da fibrose hepática: estudo em camundongos geneticamente modificados / Role of connexins 43 and 32 on the development of hepatic fibrosis: a study in genetically modified mice
A fibrose hepática resulta da cronicidade da injúria celular, ocasionando acúmulo dos componentes da matriz extracelular (MEC) pela ativação, principalmente, de células estreladas e fibroblastos portais em miofibroblastos. Estas células se conectam através de junções comunicantes do tipo gap, formadas por proteínas denominadas conexinas (Cx). As j
Publicado em: 2010
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6. Potentiation of carbon tetrachloride hepatotoxicity by pentosan polysulfate in rats
Few data are available in the literature regarding the effect of pentosan polysulfate (PPS) on normal and fibrotic rat livers. In addition, the combination of PPS and carbon tetrachloride (CCl4) has not been studied so far. The objective of this study was to assess the effect of PPS on rat livers treated or not with CCl4 for the induction of liver fibrosis.
Publicado em: 2010
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7. Potent anti-fibrogenic effects of snitroso-n-acetylcysteine (SNAC) in liver carcinogenesis and fibrogenesis: in vitro studies
Publicado em: 2008
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8. Oxidized low-density-lipoprotein accumulation is associated with liver fibrosis in experimental cholestasis
OBJECTIVE: The aim of the present study was to examine the probable relationship between the accumulation of oxLDL and hepatic fibrogenesis in cholestatic rats. INTRODUCTION: There is growing evidence to support the current theories on how oxidative stress that results in lipid peroxidation is involved in the pathogenesis of cholestatic liver injury and fibr
Clinics. Publicado em: 2008
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9. Alterações da matriz extracelular do fígado, baço e linfonodos cervicais de cães naturalmente infectados com Leishmania (Leishmania) chagasi
The aim of this work was study the extracellular matrix alterations in liver, spleen and cervical lymph nodes in dogs naturally infected with Leishmania (Leishmania) chagasi correlating with clinical aspects, histological, parasitological and immunological. This study was carried out with 30 dogs, divided at three groups: ten not infected animals (group cont
Publicado em: 2008
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10. Esteatose hepática em ratos: efeitos de dieta com diferentes níveis de substituição lipídica por dieptanoína e trieptanoína.
Hepatic steatosis is characterised by accumulation of triacylglycerols in the cytoplasm of hepatocytes at a level that reaches 5 to 40% of the weight of the liver. Its prevalence has increased worldwide, having a strong relationship with diabetes mellitus type 2 and obesity, diseases that constitute a global epidemic. Despite having been considered for a con
Publicado em: 2007
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11. O papel da cirurgia de descompressão portal e o desenvolvimento de insuficiência hepática no curso evolutivo da esquistossomose hepatoesplênica.
Morbidity and mortality of hepatosplenic schistosomiasis (HSS) are basically determined by portal hypertension and gastrointestinal bleeding due to rupture of esophageal and gastric varices. Based on the classic concept that HSS is a fibrosing condition, which does not affect liver function, the surgical treatments have been considered an efficient and safe
Publicado em: 2007
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12. On the presence of hepatic stellate cells in portal spaces
Previous studies in mice with hypervitaminosis A have demonstrated that fat-storing cells (hepatic stellate cells-HSCs) participate in schistosomal granuloma fibrogenesis. The origin of such cells in portal areas, away from the Disse spaces, was herein investigated. HSCs were identified in frozen sections of the liver by means of Sudan III staining. They app
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-05