Lung Physiopathology
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Effect of the systemic administration of methylprednisolone on the lungs of brain-dead donor rats undergoing pulmonary transplantation
OBJECTIVE: Most lung transplants are obtained from brain-dead donors. The physiopathology of brain death involves hemodynamics, the sympathetic nervous system, and inflammatory mechanisms. Administering methylprednisolone 60 min after inducing brain death in rats has been shown to modulate pulmonary inflammatory activity. Our objective was to evaluate the e
Clinics. Publicado em: 2014-02
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2. Effect of methylprednisolone on perivascular pulmonary edema, inflammatory infiltrate, VEGF and TGF-beta immunoexpression in the remaining lungs of rats after left pneumonectomy
Pneumonectomy is associated with high rates of morbimortality, with postpneumonectomy pulmonary edema being one of the leading causes. An intrinsic inflammatory process following the operation has been considered in its physiopathology. The use of corticosteroids is related to prevention of this edema, but no experimental data are available to support this h
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-07
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3. Inactivation of capsaicin-sensitive nerves reduces pulmonary remodeling in guinea pigs with chronic allergic pulmonary inflammation
Pulmonary remodeling is an important feature of asthma physiopathology that can contribute to irreversible changes in lung function. Although neurokinins influence lung inflammation, their exact role in the extracellular matrix (ECM) remodeling remains to be determined. Our objective was to investigate whether inactivation of capsaicin-sensitive nerves modul
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-02
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4. Responsividade do tecido pulmonar periférico de pacientes com doença pulmonar obstrutiva crônica / Hyperresponsiveness of peripheral lung parenchyma in chronic obstructive pulmonary disease
Mais de 60% dos pacientes com Doença Pulmonar Obstrutiva Crônica (DPOC) podem apresentar hiper-responsividade brônquica. Entretanto, não se sabe se, além das vias aéreas, o tecido pulmonar periférico também apresenta uma resposta exagerada a um agonista na DPOC. No presente estudo foi investigado o comportamento mecânico in vitro e as alterações e
Publicado em: 2009
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5. Análise em tempo real da impedância do sistema respiratório e da mobilidade toracoabdominal em portadores de DPOC com obstrução brônquica acentuada / Real-time analysis of respiratory system impedance and thoracoabdominal mobility of COPD patients with severe bronchial obstruction
Introduction: COPD is carachterized by airflow limitation associated abnormal inflammatory response of the lung to noxious particles or gases. The mechanical alterations associated with COPD have been related with dysfunction of the diaphragm, observed since the initial phases of the disease. Several studies have confirmed the high potential of FOT in the as
Publicado em: 2009
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6. Evaluation of the mechanics of the respiratory system using PV curves in patients with idiopathic pulmonary fibrosis / Avaliação da mecânica do sistema respiratório através da obtenção de curva PV em pacientes com pneumonia intersticial idiopática
The objective of this study was to evaluate small airways compromise in Idiopathic Pulmonary Fibrosis (IPF) using pressure-volume (PV) curves of the respiratory system. We collected PV curves from twelve patients before lung biopsy, which confirmed IPF in seven patients and Hipersensitivity Pneumonia in five. All curves were fitted with a sigmoid model, V =
Publicado em: 2008
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7. Effects of the exposure to cigarette smoke and residual oil fly ash (ROFA) in lungs of C57/Bl6 mice / Efeito da exposição à fumaça de cigarro e ao resíduo de óleo diesel (ROFA) em pulmões de camundongos C57/BI6
Many of the mechanisms leading to CPOD (Chronic Pulmonary Obstructive Disease) are not completely understood. In the present study, we exposed C57/Bl6 mice, for two months, to cigarette smoke and/or ROFA (Residual Oil Fly Ash). Animals exposed to cigarette smoke had an increased in proximal airways resistance, probably due to the thickening of airways walls
Publicado em: 2008
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8. Caracterização das fases imediata e tardia da resposta inflamatória de tecido pulmonar periférico de cobaias sensibilizadas / Comparison of early and late responses to antigen of sensitized guinea pigs parenchymal lung strips
The peripheral lung parenchyma has been studied as a component of the asthmatic inflammatory response. During induced constriction, tissue resistance increases in different asthma models. Approximately 60% of the asthmatic patients show early and late responses. The late response is characterized by more severe airway obstruction. In the present study, we ev
Publicado em: 2006
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9. Criação, implementação e avaliação de um recurso didático multimídia como suporte para o ensino presencial de fisioterapia respiratória / Development and evaluation of a multimedia on-line tool for teaching respiratory therapy
Advances in information technology have been widely used in teaching health care professionals; however, we are not aware of any previous study reporting its use in the instruction of respiratory therapists. The objectives of the present study were to develop materials for teaching bronchial hygiene techniques (BHT), lung expansion techniques (LET) and oxyge
Publicado em: 2006
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10. Altered cytokine production by cystic fibrosis tracheal gland serous cells.
Human submucosal tracheal glands are now believed to play a major role in the physiopathology of cystic fibrosis (CF). We successfully developed techniques for culturing human tracheal gland serous cells from normal individuals (HTGS cells) and from CF patients (CF-HTGS cells) and have shown that the cultured cells have retained most of their in vivo epithel