Malignant Gliomas
Mostrando 1-12 de 56 artigos, teses e dissertações.
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1. Antitumor activity of irinotecan with ellagic acid in C6 glioma cells
SUMMARY OBJECTIVE: Irinotecan-based combination chemotherapies in malignant gliomas need to be examined. The aim of this study was to investigate the synergetic effect of ellagic acid, a natural polyphenolic antioxidant compound, with irinotecan, an inhibitor of topoisomerase I enzyme, on the growth, cadherin switch, and angiogenic processes of a glioma cel
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. 4-Nerolidylcatechol induces autophagy in human glioblastoma cells
ABSTRACT Gliomas account for the majority of primary malignant brain tumors and present invasive behavior into adjacent healthy tissue. While 4-NC had previously shown to induce apoptotic cell death in a melanoma model, for the glioma model described in this paper 4-NC is cytotoxic for the cells with the induction of the autophagic pathway. Trypan blue exclu
Braz. J. Pharm. Sci.. Publicado em: 01/02/2018
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3. PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3K/Akt/mTOR pathway
PCI-24781 is a novel histone deacetylase inhibitor that inhibits tumor proliferation and promotes cell apoptosis. However, it is unclear whether PCI-24781 inhibits Enhancer of Zeste 2 (EZH2) expression in malignant gliomas. In this work, three glioma cell lines were incubated with various concentrations of PCI-24781 (0, 0.25, 0.5, 1, 2.5 and 5 M) and analyze
Genet. Mol. Biol.. Publicado em: 21/10/2014
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4. Kaurene diterpene induces apoptosis in U87 human malignant glioblastoma cells by suppression of anti-apoptotic signals and activation of cysteine proteases
Gliomas are the most common and malignant primary brain tumors in humans. Studies have shown that classes of kaurene diterpene have anti-tumor activity related to their ability to induce apoptosis. We investigated the response of the human glioblastoma cell line U87 to treatment with ent-kaur-16-en-19-oic acid (kaurenoic acid, KA). We analyzed cell survival
Braz J Med Biol Res. Publicado em: 11/01/2013
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5. Avaliação do efeito do alcaloide boldina sobre modelos experimentais de malignidades do sistema nervoso central e bexiga
Plants are important sources of biologically active natural products which differ in terms of structure and biological properties. One of the biological activities of plant compounds that has attracted great interest is the ability to exert antitumoral activity in different types of cancer. Boldine is an alkaloid that occurs abundantly in the leaves and bark
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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6. Xenograft transplantation of human malignant astrocytoma cells into immunodeficient rats: an experimental model of glioblastoma
INTRODUCTION: Astrocytic gliomas are the most common intracranial central nervous system neoplasias, accounting for about 60% of all primary central nervous system tumors. Despite advances in the treatment of gliomas, no effective therapeutic approach is yet available; hence, the search for a more realistic model to generate more effective therapies is essen
Clinics. Publicado em: 2010
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7. In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model
Background: ATP is an important signalling molecule in the peripheral and central nervous system. Both glioma growth and tumor resection induces cell death, thus liberating nucleotides to the extracellular medium. Nucleotides are hydrolyzed very slowly by gliomas when compared with astrocytes and induce neuronal cell death and glioma proliferation. The objec
Publicado em: 2010
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8. Preliminary studies of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas
Arquivos de Neuro-Psiquiatria. Publicado em: 2007-09
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9. Uso do paclitaxel como potencializador da radioterapia em gliomas malignos cerebrais / Use of Paclitaxel to enhance the radiotherapy effects in the treatment of malignant cerebral gliomas
O tratamento dos gliomas malignos cerebrais é um dos grandes desafios da medicina atualmente, pois, apesar do grande avanço no conhecimento destes tumores, o prognóstico de vida dos portadores desta doença é muito ruim. Foram estudados retrospectivamente 61 pacientes com diagnóstico de glioblastoma multiforme ou astrocitoma anaplásico, no período de
Publicado em: 2006
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10. Mecanismos moleculares envolvidos na resposta anti-tumoral e resistência a atra / Molecular mechanisms envolved in the anti-tumoral response and resistance to atRA
Gliomas are among the most common primary tumors of the central nervous system. Despite the advances in surgical and radiotherapy procedures and chemotherapy protocols, efficient treatment is still not available. Retinoic acid is a anti-proliferative agent used for treatment of a number of pre-malignant lesions and tumors, as promyelocytic leukemia. However,
Publicado em: 2005
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11. Pseudoprogression in boron neutron capture therapy for malignant gliomas and meningiomas
Pseudoprogression has been recognized and widely accepted in the treatment of malignant gliomas, as transient increases in the volume of the enhanced area just after chemoradiotherapy, especially using temozolomide. We experienced a similar phenomenon in the treatment of malignant gliomas and meningiomas using boron neutron capture therapy (BNCT), a cell-sel
Duke University Press.
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12. Current and Future Gene Therapy for Malignant Gliomas
Malignant gliomas are the most common neoplasm in the central nervous system. When treated with conventional treatments including surgery, irradiation, and chemotherapy, the average life expectancy of the most malignant type, glioblastoma multiforme is usually less than 1 year. Therefore, gene therapy is expected to be an effective and possibly curative trea
Hindawi Publishing Corporation.