Marine Alkaloids
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Bromopyrrole alkaloids from the caribbean sponge Agelas cerebrum
Bioguided fractionation of Agelas cerebrum crude extract resulted in isolation of four bromopyrrole and four bromopyrrole aminoimidazole alkaloids, identified as 5-bromopyrrole-2-carboxylic acid (1), 4-bromopyrrole-2-carboxylic acid (2), 3,4-bromopyrrole-2-carboxylic acid (3), 4,5-bromopyrrole-2-carboxylic acid (4), oroidin (5), bromoageliferin (6), dibromoa
Química Nova. Publicado em: 2011
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2. Investigação das condições de crescimento e produção de metabólitos secundários das linhagens de fungos Penicillium citrinum e Penicillium oxalicum / Investigation of conditions for growth and production of secondary metabolites of fungi strains P. citrinum and P. oxalicum
In this study, two species of fungi isolated from the marine environment had their active extracts against Staphylococcus aureus and Candida albicans to a strain of P. citrinum, and activity cytotoxic and against Mycobacterium tuberculosis to a strain of P. oxalicum. This studied aims the optimization their growth conditions for the production of secondary m
Publicado em: 2010
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3. Contribuição ao Conhecimento Químico de Esponjas do Litoral Cearense: Monanchora arbuscula / Contribution to Knowledge of Chemical Sponges Coastal Ceará: Monanchora arbuscula
Monanchora arbuscula (DUCHASSAING &MICHELOTTI, 1864) (Crambeidae) is an incrustant sponge, massive or branched with 15 cm high. Its color ranges from salmon to bright red or light pink with white conspicuous channels. Previous studies of M. arbuscula led to the isolation of some polycyclic guanidine alkaloids; ptilocaulin, 8bhydroxyptilocaulin, dehydrobatzel
Publicado em: 2008
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4. Do isolamento à síntese da convolutamidina A
Convolutamydine A is a member of a family of oxindole alkaloids isolated from the Floridian marine bryozan Amathia convoluta in 8.6x10-6 % yield. This compound is interesting as it has been described in the literature to have significant pharmacological activity. When bioactive substances are isolated in low yields, such as in the case of convolutamydine A,
Química Nova. Publicado em: 2008
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5. Estudos visando a construção de sistemas 6-Aza-[4. 5. 0]-espirobiciclodecano : aplicação na sintese de haliclorina e analogos / Studies toward the 6-Azaspiro[4. 5. 0] decane systems : application in the halichlorine and analogs
Os alcalóides marinhos haliclorina (1), ácido pináico (2) e ácido tauropináico (3), isolados, por D. Uemura e colaboradores em 1996, apresentam em comum um sistema 6-aza-[4.5.0]-espirobiciclodecano. A atividade biológica da haliclorina (1) está relacionada com a inibição de moléculas associadas à adesão de células vasculares (VCAM-1) com IC50 de
Publicado em: 2006
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6. Secondary Metabolites of Flustra foliacea and Their Influence on Bacteria
The North Sea bryozoan Flustra foliacea was investigated to determine its secondary metabolite content. Gas chromatography-mass spectrometry analysis of a dichloromethane extract of the bryozoan enabled 11 compounds to be identified. Preparative high-performance liquid chromatography of the extract resulted in the isolation of 10 brominated alkaloids (compou
American Society for Microbiology.
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7. Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters.
Dihydroteleocidin B, which is a derivative of teleocidin from Streptomyces, showed potent tumor-promoting activity in vivo when painted on mouse skin. Although the chemical structure of dihydroteleocidin B is entirely different from those of phorbol esters, the tumor-promoting activity of dihydroteleocidin B was found to be comparable to that of 12-O-tetrade
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8. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.
The bryostatins are macrocyclic lactones that represent an additional structural class of potent activators of protein kinase C. These marine animal biosynthetic products are of unusual interest because they induce only a subset of the biological responses induced by the phorbol esters. We have now determined the binding affinities of naturally occurring and