Matrix Metalloproteinase 20
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. Ganoderma lucidum, a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in rats
Abstract Purpose: Ganoderma lucidum, a kind of mushroom used for its antioxidant, anti-inflammatory, and immunomodulatory activities, was investigated in the present study for its possible healing effect on calvarial defects with bone grafts. Methods: Wistar male rats (n = 30) were divided into 3 groups: 1) the control (defect) group (n = 10), 2) defect an
Acta Cir. Bras.. Publicado em: 25/11/2019
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2. Methotrexate associated to lipid core nanoparticles improves cardiac allograft vasculopathy and the inflammatory profile in a rabbit heart graft model
Coronary allograft vasculopathy is an inflammatory-proliferative process that compromises the long-term success of heart transplantation and has no effective treatment. A lipid nanoemulsion (LDE) can carry chemotherapeutic agents in the circulation and concentrates them in the heart graft. The aim of the study was to investigate the effects of methotrexate (
Braz J Med Biol Res. Publicado em: 17/08/2017
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3. In vivo performance of different scaffolds for dental pulp stem cells induced for odontogenic differentiation
Abstract This study was designed to determine the in vivo performance of three different materials as scaffolds for dental pulp stem cells (DPSC) undergoing induced odontogenic differentiation. An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. Mesenc
Braz. oral res.. Publicado em: 28/11/2016
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4. Neutrophil elastase ameliorates matrix metalloproteinase-9 to promote lipopolysaccharide-induced acute lung injury in mice 1
ABSTRACT PURPOSE: To investigate the regulatory roles of neutrophil elastase (NE) and matrix metalloproteinase-9 (MMP-9) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. METHODS: To construct LPS-induced ALI mouse models, wild-type C57BL/6 mice were administered 5.0 mg/kg of LPS through endotracheal, and/or 1.0 mg/kg of ONO-5046, and/
Acta Cir. Bras.. Publicado em: 2016-06
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5. Medium modification with bone morphogenetic protein 2 addition for odontogenic differentiation
Abstract The aim of this study was to evaluate whether medium modification improves the odontogenic differentiation of human dental pulp stem cells (DPSC) in vitro and in vivo. DPSC isolated from human impacted third molar teeth were analysed for clusters of differentiation with flow cytometry. Odontogenic differentiation was stimulated by medium modificatio
Braz. oral res.. Publicado em: 08/03/2016
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6. Characterization of reactive stroma in prostate cancer: involvement of growth factors, metalloproteinase matrix, sexual hormones receptors and prostatic stem cells
ABSTRACT Introduction and Objectives: Reactive Stroma (RStr) is observed in many human cancers and is related to carcinogenesis. The objectives of the present study were to stablish a relationship of the RStr microenvironment with prostate cancer (Pca) through a morphological and molecular characterization, and to identify a possible relationship between RS
Int. braz j urol.. Publicado em: 2015-10
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7. Protective effects of tumor necrosis factor-α blockade by adalimumab on articular cartilage and subchondral bone in a rat model of osteoarthritis
We aimed to investigate the effects of an anti-tumor necrosis factor-α antibody (ATNF) on cartilage and subchondral bone in a rat model of osteoarthritis. Twenty-four rats were randomly divided into three groups: sham-operated group (n=8); anterior cruciate ligament transection (ACLT)+normal saline (NS) group (n=8); and ACLT+ATNF group (n=8). The rats in th
Braz J Med Biol Res. Publicado em: 31/07/2015
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8. ImunoexpressÃo de metaloproteinases 2 e 14 e do inibidor TIMP-2 no cÃncer colorretal / Immunoexpression of metalloproteinases 2 and 14 and the inhibitor TIMP-2 in colorectal cancer
O cÃncer colorretal(CCR) Ã altamente prevalente nos paÃses mais ricos e industrializados. As metaloproteinases de matriz (MMPs) sÃo importantes enzimas que facilitam a invasÃo e disseminaÃÃo do tumor em vÃrios tipos de cÃncer, inclusive o colorretal. Os inibidores teciduais de metaloproteinases (TIMPs) sÃo os principais inativadores fisiolÃgicos d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/08/2012
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9. Effects of genetic and environmental alterations on the birefringence of dental enamel organic matrix / Efeitos de alterações geneticas e ambientais sobre a birrefringencia da matriz organica do esmalte dentario
O esmalte envolve a porção coronária dos dentes e constitui a estrutura mais mineralizada do corpo vertebrado. Seu desenvolvimento tem início com secreção, processamento proteolítico e auto-agregação de uma complexa mistura de proteínas. O estabelecimento de uma matriz orgânica ordenada parece ser fundamental para a formação adequada da fase min
Publicado em: 2008
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10. Dose-dependent in vitro inhibition of rabbit corneal matrix metalloproteinases by an extract of Pothomorphe umbellata after alkali injury
The in vitro ability of Pothomorphe umbellata ethanolic crude extract to inhibit matrix metalloproteinase (MMP) in normal cornea and in cornea after alkali injury was demonstrated. Corneas of albino rabbits were injured with 1 N NaOH for 20 s. After 48 h the corneas were excised, homogenized and analyzed for MMP-9 (92 kDa), pro-MMP-2 (72 kDa) and MMP-2 (67 k
Brazilian Journal of Medical and Biological Research. Publicado em: 04/06/2007
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11. Evaluation of matrix metalloproteinases 2 and 9 and CD31 immune staining in squamous cell carcinomas of the floor of the mouth / Avaliação imunoistoquímica da expressão das metaloproteinases de matriz 2 e 9 e CD31 em carcinomas espinocelulares de soalho bucal
Avaliar a expressão das MMPs 2 e 9 e CD31 por meio de imunoistoquímica em carcinomas espoinocelulares de soalho bucal, e correlacionar os resultados com variáveis demográficas, estadiamento tumoral TNM, parâmetros microscópicos, como invasão perineural, embolização, grau de diferenciação tumoral, e sobrevida. Material e métodos: dados de prontuá
Publicado em: 2007
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12. A role for matrix metalloproteinase-9 in the hemodynamic changes following acute pulmonary embolism / Participação da metaloproteinase 9 da matriz extracelular nas alterações hemodinamicas apos embolia pulmonar aguda
Metaloproteinases modulam a contratilidade vascular e podem afetar a hipertensão pulmonar que ocorre na embolia pulmonar induzida (EPA). Nós examinamos os efeitos da administração de doxiciclina ( um inibidor das metaloproteinases) em cães anestesiados e submetidos à EPA. Métodos: 5 cães no grupo sham receberam somente salina. EPA foi induzida por in
Publicado em: 2007