Matrix S P I R
Mostrando 1-12 de 32 artigos, teses e dissertações.
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1. Decellularization of placentas: establishing a protocol
Biological biomaterials for tissue engineering purposes can be produced through tissue and/or organ decellularization. The remaining extracellular matrix (ECM) must be acellular and preserve its proteins and physical features. Placentas are organs of great interest because they are discarded after birth and present large amounts of ECM. Protocols for decellu
Braz J Med Biol Res. Publicado em: 17/11/2017
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2. Methotrexate associated to lipid core nanoparticles improves cardiac allograft vasculopathy and the inflammatory profile in a rabbit heart graft model
Coronary allograft vasculopathy is an inflammatory-proliferative process that compromises the long-term success of heart transplantation and has no effective treatment. A lipid nanoemulsion (LDE) can carry chemotherapeutic agents in the circulation and concentrates them in the heart graft. The aim of the study was to investigate the effects of methotrexate (
Braz J Med Biol Res. Publicado em: 17/08/2017
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3. Cotransfected human chondrocytes: over-expression of IGF-I and SOX9 enhances the synthesis of cartilage matrix components collagen-II and glycosaminoglycans
Damage to cartilage causes a loss of type II collagen (Col-II) and glycosaminoglycans (GAG). To restore the original cartilage architecture, cell factors that stimulate Col-II and GAG production are needed. Insulin-like growth factor I (IGF-I) and transcription factor SOX9are essential for the synthesis of cartilage matrix, chondrocyte proliferation, and phe
Braz J Med Biol Res. Publicado em: 06/10/2015
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4. Periostin as a modulator of chronic cardiac remodeling after myocardial infarction
OBJECTIVE: After acute myocardial infarction, during the cardiac repair phase, periostin is released into the infarct and activates signaling pathways that are essential for the reparative process. However, the role of periostin in chronic cardiac remodeling after myocardial infarction remains to be elucidated. Therefore, the objective of this study was to
Clinics. Publicado em: 2013-10
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5. Young's modulus of Al/SiC P/MgAl2O4 composites with different particle size distribution of reinforcements
The effect of particle size distribution of SiC particulate reinforcements coated with colloidal SiO2 on Young´s modulus of Al/SiCp/MgAl2O4 composites fabricated by reactive infiltration was investigated. Composites were prepared from porous preforms of silica-coated α- SiC powders of 10, 54, 86, and 146 μm, 0.6 volume fraction of reinforcements and parti
Matéria (Rio de Janeiro). Publicado em: 2010
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6. Contributions to the understanding and planning of urban occupation of Baixada de Jacarepagua - Rio de Janeiro / RJ: an application of matrix S.P.I.R. / Contribuições para o entendimento e planejamento da ocupação urbana da Baixada de Jacarepaguá - Rio de Janeiro / RJ: uma aplicação da matriz P.E.I.R
This dissertation presents a geographical approach, applying the methodology Matrix PEIR, in Baixada Jacarepaguá. The Brazilian coast, the colonial period to the present day, has suffered a progressive human occupation that gradually degrades and distorting the natural coastal environments, rather than new forms of urban environment. The marshland is an Jac
Publicado em: 2009
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7. Multicellular spheroids of bone marrow stromal cells: a three-dimensional in vitro culture system for the study of hematopoietic cell migration
Cell fate decisions are governed by a complex interplay between cell-autonomous signals and stimuli from the surrounding tissue. In vivo cells are connected to their neighbors and to the extracellular matrix forming a complex three-dimensional (3-D) microenvironment that is not reproduced in conventional in vitro systems. A large body of evidence indicates t
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-10
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8. Serum laminin, type IV collagen and hyaluronan as fibrosis markers in non-alcoholic fatty liver disease
Hepatic fibrosis in patients with non-alcoholic fatty liver disease is associated with progression of the disease. In the present study, we analyzed the discriminative ability of serum laminin, type IV collagen and hyaluronan levels to predict the presence of fibrosis in these patients. In this preliminary report, we studied 30 overweight patients divided in
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-05
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9. Desenvolvimento de biossensores eletroquimicos como ferramenta para avaliação da capacidade antioxidante de extratos vegetais / Development of electrochemical biosensors as a tool for evaluation of the antioxidant capacity of vegetables extracts
This work describes the development of two kind of electrochemical biosensors to evaluate the antioxidant capacity of vegetables extracts. The first biosensor developed was based on horseradish peroxidase immobilized on silica coated with titanium oxide and this material was employed to modify the carbon paste. In the optimized conditions, the biosensor resp
Publicado em: 2005
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10. Heterofucans from Dictyota menstrualis have anticoagulant activity
Fucan is a term used to denote a family of sulfated L-fucose-rich polysaccharides which are present in the extracellular matrix of brown seaweed and in the egg jelly coat of sea urchins. Plant fucans have several biological activities, including anticoagulant and antithrombotic, related to the structural and chemical composition of polysaccharides. We have e
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-02
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11. Clinical and molecular analysis of human reproductive disorders in Brazilian patients
Several genes that influence the development and function of the hypothalamic-pituitary-gonadal-axis (HPG) have been identified. These genes encode an array of transcription factors, matrix proteins, hormones, receptors, and enzymes that are expressed at multiple levels of the HPG. We report the experience of a single Endocrinology Unit in the identification
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-01
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12. Novos desenvolvimentos e aplicaÃÃes de mÃtodos de quÃmica quÃntica para compostos de coordenaÃÃo com Ãons lantanÃdeos
Theoretical studies on lanthanide compounds were performed, and divided into three parts: (i) generalization of the Linderberg-Seamans equations for an s-p-d-f basis set; (ii) study of the ligand-to-lanthanide ion charge transfer transitions (LMCT) with the ZINDO98 program using the INDO/S semiempirical hamiltonian and (iii) a study of point charge and charg
Publicado em: 2003