Mecamylamine
Mostrando 1-12 de 38 artigos, teses e dissertações.
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1. Um estudo sobre a interação dos sistemas colinérgico nicotínico e dopaminérgico na persistência de memórias aversivas
Long-term memory (LTM) storage requires activation of the ventral tegmental area (VTA)- hippocampus dopaminergic loop and synthesis of brain-derived neurotrophic factor (BDNF) late after learning (Bekinschtein et al., 2007; Rossato et al., 2009). Nicotinic acetylcholine receptors (nAChR) modulate VTA function. Therefore, we analyzed the involvement of these
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2012
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2. Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: roles of the peripheral vasopressin and central cholinergic systems
Our objective was to investigate in conscious Sprague-Dawley (6-8 weeks, 250-300 g) female rats (N = 7 in each group) the effects of intracerebroventricularly (icv) injected adrenomedullin (ADM) on blood pressure and heart rate (HR), and to determine if ADM and calcitonin gene-related peptide (CGRP) receptors, peripheral V1 receptors or the central cholinerg
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
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3. Nicotine effects on LPS-induced NF-capaB in the central nervous system / Efeito da nicotina na ativação do fator de transcrição NF-B no sistema nervoso central na vigência de estímulo inflamatório induzido por lipopolissacarídeo (LPS)
Nicotine is an alkaloid extracted from Tobacco plants, and it acts as an agonist in neurons and other cells that express nicotinic receptors. This substance crosses the blood brain barrier and mimics endogenous acetylcholine in interacting with various receptor subtypes. The hippocampus and cerebellum are brain regions rich in nicotinic receptors including 7
Publicado em: 2009
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4. Influence of melatonin on the development of functional nicotinic acetylcholine receptors in cultured chick retinal cells
The influence of melatonin on the developmental pattern of functional nicotinic acetylcholine receptors was investigated in embryonic 8-day-old chick retinal cells in culture. The functional response to acetylcholine was measured in cultured retina cells by microphysiometry. The maximal functional response to acetylcholine increased 2.7 times between the 4th
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-04
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5. Influência da nicotina e da mecamelamina em teste de preferência condicionada por lugar em peixes da espécie Carassius auratus.
A nicotina é um neuromodulador do sistema nervoso central que produz ampla variedade de efeitos comportamentais. A proposta deste estudo foi investigar o papel da nicotina e da mecamelamina sobre o mecanismo de aprendizagem e memória, através de condicionamento por reforço positivo, em peixes da espécie Carassius auratus. Foram utilizados 158 animais; u
Publicado em: 2003
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6. Coantagonism of glutamate receptors and nicotinic acetylcholinergic receptors disrupts fear conditioning and latent inhibition of fear conditioning
The present study investigated the hypothesis that both nicotinic acetylcholinergic receptors (nAChRs) and glutamate receptors (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPARs) and N-methyl-d-aspartate glutamate receptors (NMDARs)) are involved in fear conditioning, and may modulate similar processes. The effects of the nAChR antagonist
Cold Spring Harbor Laboratory Press.
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7. Non-cholinergic nervous control of catecholamine secretion from perfused bovine adrenal glands.
1. Field stimulation of adrenal nerves was used to study nervous control of adrenal catecholamine secretion in isolated, retrogradely perfused, bovine adrenal glands. 2. Secretion of both adrenaline and noradrenaline was maximal at 10 Hz. Secretion at 2 Hz was < 10% of maximum. Stimulating with trains of pulses at ten times the average frequency for 1 s out
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8. Mechanisms Regulating the Cardiac Output Response to Cyanide Infusion, a Model of Hypoxia
When tissue metabolic changes like those of hypoxia were induced by intra-aortic infusion of cyanide in dogs, cardiac output began to increase after 3 to 5 min, reached a peak (220% of the control value) at 15 min, and returned to control in 40 min. This pattern of cardiac output rise was not altered by vagotomy with or without atropine pretreatment. However
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9. The action of cholinomimetic substances on impulse conduction in the habenulointerpeduncular pathway of the rat in vitro.
The effects of some cholinomimetic substances and their antagonists on the peak height of compound action potentials recorded from the terminal region of the habenulointerpeduncular pathway have been studied using a rat brain slice preparation. Carbachol and acetylcholine (ACh) depressed the peak height of the compound action potential and increased the late
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10. Non-cholinergic component of rat splanchnic nerves predominates at low neuronal activity and is eliminated by naloxone.
1. Effects of nicotinic (mecamylamine) and muscarinic (atropine) receptor antagonists were investigated on the secretion of catecholamines evoked by stimulation of splanchnic nerve terminals and acetylcholine in the isolated perfused adrenal gland of the rat to determine whether non-cholinergic substances released from nerve terminals participate in the secr
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11. Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats.
Galanin coexists with acetylcholine in medial septal neurons projecting to the ventral hippocampus, a projection thought to modulate memory functions. Neurochemical lesions of the nucleus basalis-medial septal area in rats impaired choice accuracy on a delayed alternation t-maze task. Acetylcholine (7.5 or 10 micrograms intraventricularly or 1 micrograms mic
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12. A patch clamp study of the nicotinic acetylcholine receptor of bovine adrenomedullary chromaffin cells in culture.
1. Acetylcholine-induced currents recorded from bovine adrenal medullary chromaffin cells maintained in culture were studied during pressure or ionophoretic applications of ACh, using the 'whole-cell' and 'outside-out' configurations of the patch clamp technique. In standard salines, ACh evoked whole-cell currents of -38 pA to -1 nA at -60 mV, which had a re