Mediation Of Pain
Mostrando 1-11 de 11 artigos, teses e dissertações.
-
1. InteraÃÃo das vias da ciclo-oxigenase-2 e da hemeoxigenase-1 / biliverdina / monÃxido de carbono no controle da nocicepÃÃo e da inflamaÃÃo / Interaction between cyclooxygenase-2 and heme oxygenase-1 / biliverdin / carbon monoxide pathways in nociception and inflammation control in rats and mice.
Introduction: Heme oxygenase-1 (HO-1) plays a preventive role in oxidative stress. In contrast, COX-2 is involved in the pathogenesis of many inflammatory diseases and COX-2 selective inhibition has been shown to be effective in reversing inflammation without gastric side effects. However, serious cardiovascular effects of some selective COX-2 inhibitors eme
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2010
-
2. Caracterização da inflamação articular induzida por fosfolipase A2 - grupo II A: determinação das alterações histopatológicas, comportamentais e mediação química. / Characterization of joint inflammation induced by phospholipase A2 - group II: determination of the histopathological changes, behavioral and chemical mediation.
As fosfolipases A2 secretadas, particularmente do grupo II são abundantes nos venenos de serpentes, incluindo o gênero Bothrops e estão envolvidas em diversos processos fisiológicos e fisiopatológicos, como inflamação e dor, incluindo artrite. Contudo, não está totalmente caracterizado o papel da FLA2 para a gênese e manutenção dos quadros de inf
Publicado em: 2010
-
3. Temporal evaluation of c-fos expression in amygdaloid and hypothalamic areas following experimental tooth movement in rats / Avaliação temporal da expressão da proteína FOS em áreas amigdalóides e hipotalâmicas após movimentação dentária experimental em ratos
In the accomplishment of the orthodontic treatment, it is described that the pain happens immediately after the application of orthodontic forces and disappears after few days. Regarding the neural pathways involved in the sensorial mediation of the orthodontic movement (OM) few are the studies that approach this theme, and in the last decades solid founds d
Publicado em: 2008
-
4. Efeitos da estimulação elétrica do córtex motor na modulação da dor: análise comportamental e eletrofisiológica em ratos / Effects of electrical stimulation of motor cortex on pain modulation: behavior and electrophysiological study in rats.
Background. The motor function has been associated to sensory and pain attenuation, before during and shortly after the muscle activity. How ever the anatomical and functional basis of this phenomenon is not yet defined. The present study was designed to set an animal model and investigate the effect of subthreshold electrical stimulation of motor cortex (MC
Publicado em: 2007
-
5. Mediação química da hiperagesia induzida pelos venenos de serpentes Bothrops jararaca e Bothrops asper e por uma miotoxina com atividade de fosfolipase A2 isolada do veneno de Bothrops asper / Chemical mediation of hyperalgesia induced by Bothrops jararaca and Bothrops asper snake venoms and by a phospholipase A2 miotoxin isolated from Bothrops asper venom.
Bothrops venoms cause pronounced local tissue-damage characterized by hemorrhage, myonecrosis, edema and pain. Venom-induced pain has been poorly investigated, despite its clinical relevance. Furthermore, the ability of antivenom to neutralize hyperalgesia induced by these venoms is not known. In the present study the hyperalgesia and edema induced by Bothro
Publicado em: 2000
-
6. Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.
Autoradiographic studies localize [3H]bradykinin receptor binding sites to the substantia gelatinosa, dorsal root, and a subset of small cells in both the dorsal root and trigeminal ganglia of the guinea pig. [3H]Bradykinin labeling is also observed over myocardial/coronary visceral afferent fibers. The localization of [3H]bradykinin receptors to nociceptive
-
7. The genetic mediation of individual differences in sensitivity to pain and its inhibition
The underlying bases of the considerable interindividual variability in pain-related traits are starting to be revealed. Although the relative importance of genes versus experience in human pain perception remains unclear, rodent populations display large and heritable differences in both nociceptive and analgesic sensitivity. The identification and cha
The National Academy of Sciences.
-
8. The role of nociceptors of cutaneous veins in the mediation of cold pain in man.
1. To test the hypothesis that nociceptors of cutaneous veins mediate cold pain, we studied in man the time course of pain intensity and skin sensibility in relation to both intracutaneous and vein wall temperature during cooling of the dorsum of the hand by ice water before and after perivenous and intravenous nerve block. 2. Upon exposure to cold, intracut
-
9. Galanin-mediated control of pain: enhanced role after nerve injury.
The endogenous inhibitory role of the neuropeptide galanin in pain transmission and spinal cord excitability was demonstrated by the use of a high-affinity galanin receptor antagonist, M-35 [galanin-(1-13)-bradykinin-(2-9)-amide]. M-35, which displaced 125I-labeled galanin from membranes of rat dorsal spinal cord with an IC50 of 0.3 nM, dose-dependently anta
-
10. Suckling and sucrose ingestion suppress persistent hyperalgesia and spinal Fos expression after forepaw inflammation in infant rats
Sweet taste and nonnutritive suckling produce analgesia to transient noxious stimuli in infant rats and humans. The present study evaluated the pain-modulating effects of sucrose and suckling in a rat model of persistent pain and hyperalgesia that mimics the response to tissue injury in humans. Fore- and hindpaw withdrawal latencies from a 30° or 48°C bras
The National Academy of Sciences of the USA.
-
11. Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation.
The original proposal that substance P is involved in the regulation of nociceptive information at the first sensory synapse in the spinal cord has been substantiated by a wide range of evidence, but definitive support has been lacking, due primarily to the lack of evidence that a specific nociceptive response in the dorsal horn can be blocked by a substance