Megestrol Acetate
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Determinação do acetato de megestrol em plasma humano por cromatrografia líquida de alta eficiência acoplada ao espectrômetro de massa : aplicação em estudo de bioequivalência / Determination of megestrol acetate in human plasma by high-performance liquid chromatography coupled to mass spectrometry: application to a bioequivalence study
A sensitive and highly selective liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed to determine megestrol acetate in human plasma using betamethazone as the internal standard. The analyte and internal standard were extracted from plasma samples by hexane/ethyl acetate (1:1 v/v), and chromatographed on a C18 column. The mobile pha
Publicado em: 2004
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2. Mammary fibroadenomatous hyperplasia in a young cat attributed to treatment with megestrol acetate
A male, neutered cat was presented for lethargy, reluctance to walk, and mammary enlargement after recent treatment with megestrol acetate. Mammary fibroadenomatous hyperplasia was diagnosed on the basis of history, clinical signs, and histopathological findings. Pathogenesis, clinical signs, and treatment options for mammary fibroadenomatous hyperplasia att
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3. Oral contraceptives and tryptophan metabolism: Effects of oestrogen in low dose combined with a progestagen and of a low-dose progestagen (megestrol acetate) given alone
The effect upon tryptophan metabolism of the use of combined oestrogen-progestagen oral contraceptives containing a low (0·05 mg) dose of oestrogen, or of the continuous administration of megestrol acetate, has been studied by determining the excretion of tryptophan metabolites in urine collected after a 2 g oral dose of the amino acid.
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4. Pharmacokinetic interaction of megestrol acetate with zidovudine in human immunodeficiency virus-infected patients.
This nonrandomized, two-period crossover study was performed to assess whether concomitant administration of megestrol acetate influences the steady-state pharmacokinetics of zidovudine and its inactive 5'-O-glucuronide metabolite. Twelve HIV-positive, asymptomatic male volunteers received a 100-mg oral capsule dose of zidovudine at least 30 min before meals
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5. Hypospadias associated with the use of high dose megestrol acetate in an HIV infected woman.
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6. Treatment with Megestrol Acetate Improves Human Immunodeficiency Virus-Associated Immune Thrombocytopenia
Splenic macrophage Fcγ receptors participate in the pathophysiology of immune cytopenias, and in such disorders, the beneficial effects of glucocorticoids are in part mediated by decreased expression of macrophage Fcγ receptors. In the animal model, progesterones, like glucocorticoids, inhibit expression of these receptors. Megestrol acetate (MA) is a prog
American Society for Microbiology.
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7. Residual Ca2+ channel current modulation by megestrol acetate via a G-protein alpha s-subunit in rat hypothalamic neurones.
1. The inhibition of voltage-activated Ca2+ channel currents by the orally active progesterone derivative, megestrol acetate (MA), was examined in freshly dissociated rat ventromedial hypothalamic nucleus (VMN) neurones using the whole-cell voltage-clamp technique with 10 mM Ba2+ as the charge carrier. 2. The steady-state inhibition of the peak high-threshol