Melanin Concentrating Hormone Mch
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Efeitos do treinamento físico intenso e da restrição alimentar sobre a ação da leptina mediada pelo hormônio concentrador de melanina no eixo reprodutor de ratas. / Effects of intense physical training and food restriction on the action of leptin mediated by melanin concentrating hormone in the reproductive axis in female rats.
Avaliamos o efeito do treinamento físico intenso e da restrição alimentar no eixo reprodutor e na expressão do RNAm do MCH em ratas fêmeas. Utilizamos ratas fêmeas sedentárias alimentadas (SA), sedentárias com restrição alimentar, treinadas alimentadas (TA) e treinadas com restrição alimentar. O grupo TR entrou em anestro a partir da quarta seman
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/10/2011
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2. Estudo das aferências imunorreativas ao hormônio concentrador de melanina (MCH) do núcleo accumbens, no rato Long-Evans (Rattus norvegicus). / Study of melanin-concentrating hormone (MCH) immunoreactive inputs of nucleus acumbens, in rats Long-Evans (Rattus norvegicus) .
O MCH é um neuropeptídeo sintetizado preferencialmente no hipotálamo que exibe projeções para todo o neuroeixo, podendo modular vários processos fisiológicos, como a ingestão aguda de alimento. Um alvo de suas projeções é o núcleo accumbens (Acb), componente do estriado ventral envolvido na recompensa de estímulos hedônicos. Nossa contribuiçã
Publicado em: 2010
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3. Melanin-concentrating hormone and orexin A neuropeptidergic systems in the dorsal motor nucleus of the vagus nerve in rat / Sistema neuropeptidergico do hormonio concentrador de melanina e da orexina A no nucleo motor dorsal do nervo vago em rato
Melanin-concentrating hormone (MCH) and orexin-A (OXA) are neuromediators expressed in neurons distributed in the diencephalum, mainly in the lateral hypothalamic area, projecting nerve fibers to several parts of the central nervous system. These neuropeptides exert potent orexigenic activity, increasing feeding and controlling the energetic balance. Consequ
Publicado em: 2009
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4. Busca alimentar, memória espacial e ansiedade em ratos: possível participação do núcleo mamilar medial / Search for food, spatial memory and anxiety in rats: possible participation of the medial mammillary nucleus
Seres humanos com danos nos corpos mamilares exibem prejuízos no funcionamento da memória episódica. O presente estudo investigou a possível participação do núcleo mamilar medial (MM), estrutura densamente inervada por fibras imunorreativas ao hormônio concentrador de melanina (MCH) potencialmente envolvida no comportamento alimentar, em processos de
Publicado em: 2008
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5. Melanin-concentrating hormone: unique peptide neuronal system in the rat brain and pituitary gland.
A unique neuronal system was detected in the rat central nervous system by immunohistochemistry and radioimmunoassay with antibodies to salmon melanin-concentrating hormone (MCH). MCH-like immunoreactive (MCH-LI) cell bodies were confined to the hypothalamus. MCH-LI fibers were found throughout the brain but were most prevalent in hypothalamus, mesencephalon
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6. Identification and characterization of a melanin-concentrating hormone receptor
Melanin-concentrating hormone (MCH), a neuropeptide expressed in central and peripheral nervous systems, plays an important role in the control of feeding behaviors and energy metabolism. An orphan G protein-coupled receptor (SLC-1/GPR24) has recently been identified as a receptor for MCH (MCHR1). We report here the identification and characterization of a G
The National Academy of Sciences.
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7. Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism
Melanin-concentrating hormone (MCH) is a cyclic 19-aa hypothalamic neuropeptide derived from a larger prohormone precursor of MCH (Pmch), which also encodes neuropeptide EI (NEI) and neuropeptide GE (NGE). Pmch-deficient (Pmch−/−) mice are lean, hypophagic, and have an increased metabolic rate. Transgenic mice overexpressing Pmch are hyperphagic and deve
The National Academy of Sciences.
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8. Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype
Energy homeostasis is regulated by a complex network involving peripheral and central signals that determine food intake and energy expenditure. Melanin-concentrating hormone (MCH) plays an essential role in this process. Animals treated with MCH develop hyperphagia and obesity. Ablation of the prepro-MCH gene leads to a lean phenotype, as does ablation
National Academy of Sciences.
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9. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
Several lines of investigation suggest that the hypothalamic neuropeptide melanin-concentrating hormone (MCH) regulates body weight in mammals. Obese mice lacking functional leptin overexpress the MCH message in the fed or fasted state. Acute intracerebroventricular injection of MCH increases energy intake in rats. Mice lacking the MCH gene are lean. To test
American Society for Clinical Investigation.
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10. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R
Melanin-concentrating hormone (MCH) is a 19-aa cyclic neuropeptide originally isolated from chum salmon pituitaries. Besides its effects on the aggregation of melanophores in fish several lines of evidence suggest that in mammals MCH functions as a regulator of energy homeostasis. Recently, several groups reported the identification of an orphan G protein-co
The National Academy of Sciences.
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11. The melanin-concentrating hormone receptor 1, a novel target of autoantibody responses in vitiligo
Vitiligo is a common depigmenting disorder resulting from the loss of melanocytes in the skin. The pathogenesis of the disease remains obscure, although autoimmune mechanisms are thought to be involved. Indeed, autoantibodies and autoreactive T lymphocytes that target melanocytes have been reported in some vitiligo patients. The objective of this study was t
American Society for Clinical Investigation.
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12. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness. As compared with WT (CB1+/+) littermates, mice lacking CB1 (CB1–/–) exhibited reduced spontaneous caloric intake and, as
American Society for Clinical Investigation.