Metabotropic Receptor
Mostrando 1-12 de 118 artigos, teses e dissertações.
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1. Association of glutamate metabotropic receptor polymorphisms and sensorineural hearing loss in adults of different age groups
Resumo Introdução: A perda auditiva neurossensorial é um desafio comum no mundo todo, inclui uma parte da população jovem. Embora haja muitos relatos que associem o gene do receptor metabotrópico de glutamato 7 com perda auditiva neurossensorial, não há relato, até a presente data, sobre a associação de polimorfismos do receptor metabotrópico de
Braz. j. otorhinolaryngol.. Publicado em: 07/11/2019
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2. Imunodetecção do receptor metabotrópico mGluR8 no núcleo arqueado do hipotálamo de ratos Wistar e estudo dos efeitos, no receptor, resultantes da exposição oral sub-crônica ao glutamato monossódico / Imunodetecction of mGluR8 receptor in the arcuate nucleus of the hypothalamus of Wistar rats and study of the effects, on the receptor, resulting from sub-chronic exposure to monosodium glutamate
Food is part of human culture not only associated to physiological needs. Food is composed of several molecules among them amino acids. Glutamate (GLU) is the anion of one of the main amino acids found in foods that, besides being part of the food composition, is a molecule essential for human physiology. It can also be ingested due to the use of the food ad
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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3. Crises paroxísticas recorrentes em ratos por inibição do transporte de glutamato durante o desenvolvimento / Genesis of recurrent epileptic paroxysmal burst in newborn rats after inhibition of glutamate transporters
It has been previously shown that cell-surface glutamate transporters efficiently control network activity in the maturing rodent brain, preventing the generation of seizures. In particular, inhibition of glutamate transporters by DL-TBOA leads to a pathological EEG pattern in freely moving rat pups. This is composed of partial seizures and recurrent short p
Publicado em: 2009
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4. Glutamate modulation of melatonin synthesis in the rat pineal gland. / Síntese de melatonina na glândula pineal de ratos: modulação pelo glutamato.
The aim of this work was to study the effects of glutamate on melatonin synthesis, investigating the glutamate receptors involved and a possible interaction between the two predominant cell types of the pineal gland, pinealocytes and astrocytes; moreover, it was investigated the involvement of the transcription factor NF-kB on the glutama
Publicado em: 2008
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5. Expression of metabotropic glutamate receptors in the rat and chick visual system after ocular enucleation. / Expressão dos receptores metabotrópicos de glutamato no sistema visual de ratos e pintos após enucleação ocular.
Os receptores glutamatérgicos metabotrópicos (mGluRs) estão envolvidos nos processos de plasticidade, neurodegeneração e neuroproteção. Avaliamos a expressão de mGluRs no sistema visual de ratos e pintos em diferentes tempos após enucleação ocular. Os animais foram avaliados pelo método de imuno-histoquímica, immunoblotting e RT-PCR, para detec�
Publicado em: 2007
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6. Analysis of P2X2 e P2X4 receptors during neuronal differentiation / Análise dos receptores P2X2 e P2X4 durante a diferenciação neuronal
During the development of the nervous system, oscillations of intracellular calcium concentrations activate programs of gene expression resulting in proliferation, migration and neuronal differentiation of embryonic cells. In this thesis, the participation of ionotropic P2X2 and P2X4 receptor subtypes, whose receptor channels are highly permeable for calcium
Publicado em: 2007
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7. Glutamatergic neurotransmission modulates hypoxia-induced hyperventilation but not anapyrexia
The interaction between pulmonary ventilation (V E) and body temperature (Tb) is essential for O2 delivery to match metabolic rate under varying states of metabolic demand. Hypoxia causes hyperventilation and anapyrexia (a regulated drop in Tb), but the neurotransmitters responsible for this interaction are not well known. Since L-glutamate is released centr
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-10
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8. Site-specific unglycosylation to improve crystallization of the metabotropic glutamate receptor 3 extracellular domain
The site-specific unglycosylated mutant of metabotropic glutamate receptor 3 extracellular domain has been overexpressed, purified, and crystallized. A complete data set has been collected to 2.35 Å resolution.
International Union of Crystallography.
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9. Metabotropic glutamate receptor-initiated translocation of protein kinase p90rsk to polyribosomes: A possible factor regulating synaptic protein synthesis
Maintenance of lasting synaptic efficacy changes requires protein synthesis. We report here a mechanism that might influence translation control at the level of the single synapse. Stimulation of metabotropic glutamate receptors in hippocampal slices induces a rapid protein kinase C-dependent translocation of multifunction kinase p90rsk to polyribosomes; con
The National Academy of Sciences.
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10. Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein.
We have characterized a G-protein-coupled glutamate receptor in primary cultures of striatal neurons. Glutamate, quisqualate, or trans-1-aminocyclopentane-1,3-dicarboxylate inhibited by 30-40% either forskolin-stimulated cAMP production in intact cells or forskolin plus vasoactive intestinal peptide-activated adenylyl cyclase assayed in neuronal membrane pre
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11. Expression cloning of an ATP receptor from mouse neuroblastoma cells.
Extracellular ATP activates cell-surface metabotropic and ionotropic nucleotide (P2) receptors in vascular, neural, connective, and immune tissues. These P2 receptors mediate a wealth of physiological processes, including nitric oxide-dependent vasodilation of vascular smooth muscle and fast excitatory neurotransmission in sensory afferents. Although ATP is
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12. PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7
Both postsynaptic density and presynaptic active zone are structural matrix containing scaffolding proteins that are involved in the organization of the synapse. Little is known about the functional role of these proteins in the signaling of presynaptic receptors. Here we show that the interaction of the presynaptic metabotropic glutamate (mGlu) receptor sub
Oxford University Press.