Methotrexate Toxicity
Mostrando 1-12 de 42 artigos, teses e dissertações.
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1. Drug-induced nephrotoxicity
RESUMO A lesão renal aguda é um diagnóstico muito comum, presente em até 60% dos pacientes críticos, e sua terceira maior causa é a toxicidade de medicamentos. A nefrotoxicidade pode ser definida como qualquer lesão renal causada por medicamentos, direta ou indiretamente, tendo a insuficiência renal aguda, tubulopatias e glomerulopatias como apresent
Rev. Assoc. Med. Bras.. Publicado em: 13/01/2020
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2. Ulcerations due to methotrexate toxicity in a psoriasis patient
Abstract: Methotrexate is one of the most used drugs in the treatment of psoriasis with indication of systemic therapy. Cutaneous and mucous side effects are described by pharmacological characteristics of the drug itself or due to overdose. We report the case of a patient with ulcerations in oral mucosa and psoriatic plaques after incorrect use of Methotrex
An. Bras. Dermatol.. Publicado em: 2016-06
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3. Combined acute interstitial pneumonitis and pancytopenia induced by low-dose methotrexate in a hemodialysis patient treated for bullous pemphigoid
AbstractMethotrexate has been widely used for many years in the treatment of a variety of diseases. Acute pneumonitis and bone marrow suppression are very serious side effects in methotrexate treatment. A 48-year-old man with end-stage renal disease undergoing chronic hemodialysis developed combined acute pneumonitis and pancytopenia after a cumulative dose
An. Bras. Dermatol.. Publicado em: 2015-06
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4. T-cell large granular lymphocytic leukemia: treatment experience with fludarabine
OBJECTIVES: The aim of this retrospective study was to investigate the results of T-cell large granular lymphocytic leukemia treatment with fludarabine by assessing the complete hematologic response, the complete molecular response, progression-free survival, and overall survival. METHODS: We evaluated the records of six patients with T-cell large granular l
Clinics. Publicado em: 2012-07
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5. Brazilian experience using high dose sequential chemotherapy followed by autologous hematopoietic stem cell transplantation for malignant lymphomas
OBJECTIVE: To evaluate the use of high-dose sequential chemotherapy in a Brazilian population. METHODS: High-dose cyclophosphamide followed by autologous hematopoietic stem cell transplantation is an effective and feasible therapy for refractory/relapsed lymphomas; this regimen has never before been evaluated in a Brazilian population. All patients (106 with
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011-12
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6. A comparison of vitamin A and leucovorin for the prevention of methotrexate-induced micronuclei production in rat bone marrow
INTRODUCTION: Methotrexate, a folate antagonist, is a mainstay treatment for childhood acute lymphoblastic leukemia. It is also widely used in a low dose formulation to treat patients with rheumatoid arthritis. In rats, methotrexate is known to induce micronuclei formation, leading to genetic damage, while vitamin A is known to protect against such methotrex
Clinics. Publicado em: 2008
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7. Perfil FitogrÃfico e FarmacolÃgico da Aspidosperma pyriolium mart. "Ensaios prÃ-clÃnicos"
The use of natural products has been growing remarkably in recent years. The search pharmacology of medicinal plants has not only brought about important advances for the treatment of various diseases, but also has provided extremely useful tools for the theoretical study of physiology and pharmacology. Aspidosperma pyrifolium Mart. occurs in the caatinga an
Publicado em: 2008
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8. Uso de uma nanoemulsão rica em colesterol (LDE) como veículo para o di-dodecil metotrexato / Use of a cholesterol-rich nanoemulsion (LDE) as vehicle for di-dodecyl methotrexate
O uso da LDE como veículo para quimioterápicos tem mostrado ser uma boa estratégia para aumentar a eficácia terapêutica dos mesmos. Nesse estudo, a LDE foi empregada como veículo para um derivado lipofílico do metotrexato (MTX), o di-dodecil metotrexato, que foi obtido com rendimento elevado através de reação de esterificação do MTX. O aumento na
Publicado em: 2007
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9. High-dose cyclophosphamide followed by autologous peripheral blood progenitor cell transplantation improves the salvage treatment for persistent or sensitive relapsed malignant lymphoma
Trials have demonstrated that high-dose escalation followed by autologous transplantation can promote better long-term survival as salvage treatment in malignant lymphomas. The aim of the present nonrandomized clinical trial was to demonstrate the role of high-dose cyclophosphamide (HDCY) in reducing tumor burden and also to determine the effectiveness of HD
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-01
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10. Survival and drug discontinuation analyses in a large cohort of methotrexate treated rheumatoid arthritis patients.
OBJECTIVES--To determine the probability of drug continuation in a large cohort of methotrexate treated rheumatoid arthritis (RA) patients, the reasons for discontinuation of methotrexate, the overall survival of the members of this cohort, and the causes of death in these patients. METHODS--Yearly follow up was conducted in methotrexate treated RA patients
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11. Model for specific rescue of normal hepatocytes during methotrexate treatment of hepatic malignancy.
We utilized the presence of hepatic receptors for galactose-terminal glycoproteins to achieve specific rescue of differentiated hepatocytes from methotrexate toxicity. This was accomplished by administration of a conjugate formed by covalent coupling of the methotrexate antagonist, folinic acid (leucovorin), to galactose-terminating (desialylated) bovine fet
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12. New approach to antifolate treatment of certain cancers as demonstrated in tissue culture.
The selective toxicity of antifolates for a variety of cancers can be improved, as illustrated by the combined administration of N5-methyltetrahydrofolate and methotrexate in tissue culture. When a variety of neoplastic cell types characterized by a deficiency of vitamin B12-dependent N5-methyltetrahydrofolate methyltransferase (5-methyltetrahydropteroyl-L-g