Mevalonic Acid
Mostrando 1-12 de 71 artigos, teses e dissertações.
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1. Effect of precursors feeding and media manipulation on production of novel anticancer pro-drug camptothecin from endophytic fungus
We have established methodology for the isolation and characterization of a novel endophytic fungus from the inner bark of medicinal plant Nothapodytes foetida, which produced camptothecin in Sabouraud broth (SB) under shake flask conditions. Camptothecin and its related compounds are at present obtained by extraction from intact plants, but fungal endopytes
Braz. J. Microbiol.. Publicado em: 2012-12
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2. Obtenção e propriedades de toruleno da levedura Rhodotorula glutinis / Obtaining and properties of torulene from Rhodotorula glutinis yeast
Carotenoids are natural colorants, some of which are precursors of vitamin A. Since the past decade, an important role in reducing the risk of various degenerative diseases was attributed to these compounds. With these vital functions, the search for sources has intensified worldwide. The biotechnological production of specific carotenoids, using bacteria, f
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/11/2011
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3. Production of Mevalonic Acid by Fermentation
The purpose of this investigation was to select microorganisms that produce substantial quantities of mevalonic acid and to develop an economic fermentation process. To screen for mevalonic acid-producing microorganisms, it was necessary to improve the method for the quantitative determination of this acid. The biological assay was modified by shortening the
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4. Neutrophils are required for the DNA synthetic response of human lymphocytes to mevalonic acid: evidence suggesting that a nonsterol product of mevalonate is involved.
Human peripheral blood lymphocytes, in the presence of human neutrophils, initiate DNA synthesis and cell cycling when exposed to mevalonic acid. The ability of lymphocytes to respond in this manner is a radiosensitive property of cells, whereas the help provided by neutrophils is maintained despite their exposure to x-irradiation. Other organic acid anions,
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5. METABOLISM OF MEVALONIC ACID BY LACTOBACILLUS PLANTARUM
Durr, I. F. (American University of Beirut, Beirut, Lebanon), and A. N. Shwayri. Metabolism of mevalonic acid by Lactobacillus plantarum. J. Bacteriol. 88:361–366. 1964.—Lactobacillus plantarum strain 8014-H2, unlike other lactobacilli studied, does not require mevalonic acid for growth, but growing and resting cells utilize it only for the synthesis of
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6. The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism
LXRα is an orphan member of the nuclear hormone receptor superfamily that displays constitutive transcriptional activity. We reasoned that this activity may result from the production of an endogenous activator that is a component of intermediary metabolism. The use of metabolic inhibitors revealed that mevalonic acid biosynthesis is required for LXRα acti
The National Academy of Sciences of the USA.
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7. Biosynthesis of radiolabeled T-2 toxin by Fusarium tricinctum.
Incubation of Fusarium tricinctum NRRL 3299 on a solid rice medium in the presence of [1-14C]sodium acetate, [2-3H]mevalonic acid, [2-14C]mevalonic acid, or [5-3H]mevalonic acid yielded preparations of radiolabeled T-2 toxin with specific activities of 1.008, 1.64, 0.656, and 7.35 muCi/mmol, respectively.
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8. Effect of Light on Mevalonic Acid Incorporation into the Phytosterols of Nicotiana tabacum L. Seedlings 12
Mevalonic acid-2-14C was readily incorporated into the free, esterified, and glycosidic sterol fractions of tobacco (Nicotiana tabacum L. var. Burley 21) seedlings. The time course of mevalonic acid-2-14C incorporation was different for the various individual sterols. Campesterol and sitosterol (group I) became radioactive as the free sterol and subsequently
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9. Conversion of Mevalonic Acid to γ,γ-Dimethylallyl Pyrophosphate by Mycoplasma
Henrikson, Carl V. (University of South Dakota, Vermillion), and Paul F. Smith. Conversion of mevalonic acid to γ,γ-dimethylallyl pyrophosphate by Mycoplasma. J. Bacteriol. 92:701–706. 1966.—Three representative strains of Mycoplasma, M. laidlawii strain B, Mycoplasma sp. avian strain J, and M. hominis type 2 strain O7, were examined for the presence o
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10. Incorporation of Mevalonic Acid into Ribosylzeatin in Tobacco Callus Ribonucleic Acid Preparations 1
The incorporation of 14C-2-mevalonic acid into transfer RNA and ribosomal RNA (high molecular weight RNA) in rapidly growing, cytokinin-dependent tobacco (Nicotiana tabacum var. Wisconsin No. 38) callus cultures has been investigated. Approximately 40% of the label incorporated into transfer RNA was present in a ribonucleoside with chromatographic properties
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11. Cholesterol Inhibition of Isopentenyl Pyrophosphate Δ3,Δ2-Isomerase in Mycoplasma laidlawii
Cholesterol inhibits isopentenyl Δ3,Δ2-isomerase of Mycoplasma laidlawii in an apparently competitive fashion. The conversion of mevalonic acid to isopentenyl pyrophosphate is slightly stimulated. Organisms grown in the presence of mevalonic-2-14C acid contain small amounts of radio-label in nucleic acid and protein fractions. Most of the label is found in
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12. Comparative Biosynthesis of Mevalonic Acid by Mycoplasma
Smith, Paul F. (University of South Dakota, Vermillion), and C. V. Henrikson. Comparative biosynthesis of mevalonic acid by Mycoplasma. J. Bacteriol. 89:146–153. 1965.—Three representative Mycoplasma, M. laidlawii strain B, M. gallisepticum strain J, and M. hominis strain 07, were examined for the presence or absence of enzymes associated with the biosyn