Mice And Body Weight Measurement
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity
RESUMO Objetivo Avaliar os efeitos de três tipos de treinamentos de resistência na adiposidade, na inflamação e na ação da insulina em camundongos Swiss obesos por dieta hiperlipídica. Métodos Camundongos Swiss machos magros e obesos foram selecionados e posteriormente separados em oito grupos com oito animais em cada: dieta padrão + não treinado
Einstein (São Paulo). Publicado em: 23/09/2019
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2. Caracterização da disfunção erétil em camundongos obesos tratados com dieta hiperlipídica / Characterization of erectile dysfunction in obese mice fed a high-fat diet
The prevalence of obesity is increasing every year, and a becoming a major public health problem. Obesity is considered an important risk factor for development of insulin resistance, dyslipidemia, diabetes mellitus type 2 and arterial hypertension. These are risk factors that act synergistically in the development of erectile dysfunction. However, so far fe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2011
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3. Indican, Ãndigo e indirubina de folhas de indigofera suffruticosa sobre linhagens celulares neoplÃsicas
Ãndigo e Indirubina sÃo derivados da oxidaÃÃo e dimerizaÃÃo do indoxil e isatan e liberados pelo composto precursor, Indican ou Isatan B. A Indirubina inibe a sÃntese de DNA de algumas linhagens celulares. Este trabalho experimental foi desenvolvido para avaliar os efeitos dos compostos quÃmicos identificados e isolados de folhas de Indigofera suffru
Publicado em: 2008
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4. Rapid, Simple In Vivo Screen for New Drugs Active against Mycobacterium tuberculosis
We evaluated the use of a simple and easy-to-obtain potential marker of tuberculosis (TB) drug efficacy, body weight, and correlated weight loss or gain with the number of CFU of Mycobacterium tuberculosis in lungs and spleens of infected mice. C3H mice were infected intravenously with 106 CFU of virulent M. tuberculosis H37Rv, and body weight was evaluated
American Society for Microbiology.
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5. Measurement of Respiratory Volume for Virus Retention Studies in Mice
A pressure plethysmograph for measuring respiratory volume in mice during exposure to virus aerosols is described. The respiratory frequency and tidal volume were measured, and from these data the minute ventilation was calculated. The mean respiratory frequency of adult, male mice was 255 per min; the mean tidal volume of 0.18 ml was inversely related to re
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6. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
Recent data have identified leptin as an afferent signal in a negative-feedback loop regulating the mass of the adipose tissue. High leptin levels are observed in obese humans and rodents, suggesting that, in some cases, obesity is the result of leptin insensitivity. This hypothesis was tested by comparing the response to peripherally and centrally administe
The National Academy of Sciences of the USA.
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7. Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats
Assessing insulin resistance in rodent models gives insight into mechanisms that cause type 2 diabetes and the metabolic syndrome. The hyperinsulinemic euglycemic glucose clamp, the reference standard for measuring insulin sensitivity in humans and animals, is labor intensive and technically demanding. A number of simple surrogate indexes of insulin sensitiv
American Physiological Society.
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8. Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity
Human cytochrome P-450 (CYP)2J2 is abundant in heart and active in biosynthesis of epoxyeicosatrienoic acids (EETs). Recently, we demonstrated that these eicosanoid products protect myocardium from ischemia-reperfusion injury. The present study utilized transgenic (Tr) mice with cardiomyocyte-specific overexpression of human CYP2J2 to investigate protection
American Physiological Society.
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9. Pefloxacin-Induced Achilles Tendon Toxicity in Rodents: Biochemical Changes in Proteoglycan Synthesis and Oxidative Damage to Collagen
Despite a relatively low incidence of serious side effects, fluoroquinolones and the fluoroquinolone pefloxacin have been reported to occasionally promote tendinopathy that might result in the complication of spontaneous rupture of tendons. In the present study, we investigated in rodents the intrinsic deleterious effect of pefloxacin (400 mg/kg of body weig
American Society for Microbiology.
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10. The In Vivo Susceptibility of Leishmania donovani to Sodium Stibogluconate Is Drug Specific and Can Be Reversed by Inhibiting Glutathione Biosynthesis
Resistance to pentavalent antimonial (Sbv) agents such as sodium stibogluconate (SSG) is creating a major problem in the treatment of visceral leishmaniasis. In the present study the in vivo susceptibilities of Leishmania donovani strains, typed as SSG resistant (strain 200011) or SSG sensitive (strain 200016) on the basis of their responses to a single SSG
American Society for Microbiology.
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11. Pharmacodynamics of the New Des-F(6)-Quinolone Garenoxacin in a Murine Thigh Infection Model
Garenoxacin is a new des-F(6)-quinolone with broad-spectrum activity against both gram-positive cocci and gram-negative bacilli. We used the neutropenic murine thigh infection model to characterize the time course of antimicrobial activity of garenoxacin and determine which pharmacokinetic-pharmacodynamic (PK-PD) parameter best correlated with efficacy. Seru
American Society for Microbiology.