Mimetics
Mostrando 1-12 de 51 artigos, teses e dissertações.
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1. Catalytic application of selenium and tellurium compounds as glutathione peroxidase enzyme mimetics
A glutationa peroxidase (GPx) é uma importante enzima que faz parte do sistema de defesa do organismo frente a substâncias nocivas formadas durante o metabolismo do oxigênio, como peróxidos e seus derivados. Diversas estratégias para desenvolver novos miméticos, assim como para aumentar a atividade mimética da GPx em compostos como disselenetos, selen
Journal of the Brazilian Chemical Society. Publicado em: 2010
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2. TOXICOLOGIA E FARMACOLOGIA IN VITRO DE NOVOS COMPOSTOS ORGÂNICOS DE SELÊNIO E TELÚRIO COM ATIVIDADE TIPO TIOL PEROXIDASE / TOXICOLOGY AND PHARMACOLOGY OF NEW SELENIUM AND TELLURIUM ORGANIC COMPOUNDS IN VITRO WITH THIOL PEROXIDASE ACTIVITY
Glutathione peroxidase (GPx; EC 1.11.1.9) is a well-known selenoenzyme that catalyzes the reduction of hydrogen peroxide and some organic hydroperoxides by glutathione (GSH) and protects lipid membranes and other cellular components against oxidative stress, which is related to many diseases and this enzyme is regarded as one of the most important antioxidan
Publicado em: 2009
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3. A astÃcia da mÃmesis e a (des)qualificaÃÃo do humano? : a diluiÃÃo das fronteiras entre o orgÃnico e o mecÃnico
This study examines the technological advances in the fields of Artificial Intelligence, Robotics, nanotechnology, bioinformatics, Bioengineering, Cybersecurity, from the logic that has driven: the mimesis. To this end, we relate the qualitative analysis of science fiction movies, more specifically RoboCop (1987) and Blade Runner (1982), with theoretical and
Publicado em: 2008
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4. An overview of the effects of annexin 1 on cells involved in the inflammatory process
The concept of anti-inflammation is currently evolving with the definition of several endogenous inhibitory circuits that are important in the control of the host inflammatory response. Here we focus on one of these pathways, the annexin 1 (ANXA1) system. Originally identified as a 37 kDa glucocorticoid-inducible protein, ANXA1 has emerged over the last deca
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
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5. Chelates complexes of oxovanadium (IV): potentials insulin mimetics. / Quelato complexos de oxovanádio (IV): potenciais mimetizadores de insulina.
Based on studies of another studies that explored the capacity of oxovanadium(IV) ion to mimic insulin, we had the idea to contribute with this line of research. For this, our choice of ligands was trans - 1,2 diamineciclohexane - N,N,N`,N` - tetraacétic (CDTA) and ethilenediaminetetraacétic (EDTA) acids, to synthesize the [VO(CDTA)], Na2[VO(EDTA)] and [(V
Publicado em: 2004
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6. Existência de diferentes estados de spin dos íons Fe2+ e Fe3+ do citocromo c resultante da interação com lipossomos modelos. / Existence of different heme iron Fe2+ and Fe3+ spin states cytochrome c ions results the interaction with lipid bilayers.
This association lipid/cytochrome c is interesting to study in order to understand the peroxidase activity of this protein, that plays an important role in the respiratory chain and in the apoptosis process or the programmed cell death. The nature and specificity of the interaction of cytochrome c with lipid bilayers have been major goals in recent studies,
Publicado em: 2001
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7. Nonconventional amide bond formation catalysis: programming enzyme specificity with substrate mimetics
This article reports on the design and characteristics of substrate mimetics in protease-catalyzed reactions. Firstly, the basis of protease-catalyzed peptide synthesis and the general advantages of substrate mimetics over common acyl donor components are described. The binding behavior of these artificial substrates and the mechanism of catalysis are furthe
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-05
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8. Fas-disabling small exocyclic peptide mimetics limit apoptosis by an unexpected mechanism
Fas ligand- (FasL) mediated apoptosis is an important element of tissue-specific organ damage. We have developed biologically active small exocyclic peptide mimetics that disable apoptotic functions of Fas. The most effective mimetic binds to both its receptor and FasL with comparable affinity. In vitro, the most effective antagonist blocked FasL-induced cyt
National Academy of Sciences.
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9. What's potentially more effective than a Roto-Rooter and less toxic than Drano? Anti-adhesion mimetics!
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10. RNA mimetics: oligoribonucleotide N3'-->P5' phosphoramidates.
The synthesis and properties of novel RNA mimetics, oligoribonucleotide N3'-->P5' phosphoramidates, are described. These oligonucleotides contain 3'-aminoribonucleosides connected via N3'-->P5' phosphoramidate linkages, replacing the native RNA O3'-->P5' phosphodiester counterparts. The key monomers 2'-t-butyldimethylsilyl-3'-(monomethoxytrityl)-amino-5'-pho
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11. Synthesis and properties of RNA analogs-oligoribonucleotide N3'-->P5' phosphoramidates.
The synthesis and characterization of RNA mimetics, uniformly modified oligoribonucleotide N3'-->P5' phosphoramidates containing all four natural bases (uracil, cytosine, adenine and guanine) as well as thymidine and 2,6-diaminopurine, are described. These RNA analogs contain N3'-->P5' phosphoramidate internucleotide linkages which replaced natural RNA O3'--
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12. Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues.
Neutrophil (PMN) activation is critical in inflammation and reperfusion injury, suggesting that PMN-directed therapies may be of clinical use. Here, leukotriene B4 (LTB4)-induced PMN influx in ear skin was equivalent between 5-lipoxygenase knockout and wild-type mice. To explore actions of lipoxin (LX) in PMN-mediated tissue injury, we prepared several novel