Mitogenicity
Mostrando 1-12 de 107 artigos, teses e dissertações.
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1. Purificação e caracterização das lectinas ACL-I e ACL-II da esponja marinha axinella corrugata, imunolocalização da ACL-I e avaliação do seu potencial como marcador de transformação celular / Purification and characterization of lectins ACL-I and ACL-II from the marine sponge Axinella corrugata, immunolocalization of ACL-I and its evaluation as marker of cellular transformation
A partir de extratos aquosos da esponja marinha Axinella corrugata, coletada na costa sul do Brasil (Santa Catarina), foram purificadas duas lectinas, ACL-I e ACL-II, por cromatografia em coluna de afinidade de matriz de estroma de coelhopoliacrilamida, seguida por gel filtração em Ultrogel AcA 44. Os trabalhos se concentraram, especialmente, no estudo da
Publicado em: 2008
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2. Mitogenic activities of synthetic lipid A analogs and suppression of mitogenicity of lipid A.
The effect of synthetic lipid A analogs on murine spleen cells was studied. The preparations represented D-glucosamine and D-glucosaminyl-beta 1,6-D-glucosamine disaccharide derivatives substituted in different combinations by ester- and amide-bound fatty acids and by phosphate groups. Significant mitogenic activity was demonstrated with a number of syntheti
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3. Ganglioside and monosaccharide inhibition of nonspecific lymphocyte mitogenicity by group A streptococcal pyrogenic exotoxins.
Group A streptococcal pyrogenic exotoxins (SPE) types A, B, and C are potent nonspecific lymphocyte mitogens. The mitogenicity of these exotoxins was inhibited by gangliosides and sialic acid, whereas concanavalin A was unaffected. The capacity of both concanavalin A and SPE-A to stimulate lymphocytes was suppressed by alpha-methyl-D-mannopyranoside. Galacto
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4. Mitogenicity of a lipid-deficient lipoprotein from a mutant Escherichia coli strain.
From the mutant bacterial strain Escherichia coli JE5511 lpp lpm, muropeptide-containing and muropeptide-free lipoproteins were prepared. By gas chromatography and by infrared spectroscopy we showed that the products were deficient in the two ester-bound N-terminal fatty acids, but still carried the amide-linked fatty acid. Mutant lipoproteins were tested fo
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5. Low biological activity of Helicobacter pylori lipopolysaccharide.
Lipopolysaccharide from the gastroduodenal pathogen Helicobacter pylori was tested for its ability to induce mitogenicity in mouse spleen cells, pyrogenicity in rabbits, and toxic lethality in galactosamine-sensitized mice. Compared with those for enterobacterial lipopolysaccharide, mitogenicity and pyrogenicity were a thousand-fold lower and lethal toxicity
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6. Mitogenic Effect of Bartonella bacilliformis on Human Vascular Endothelial Cells and Involvement of GroEL
Bartonellae are bacterial pathogens for a wide variety of mammals. In humans, bartonellosis can result in angioproliferative lesions that are potentially life threatening to the patient, including bacillary angiomatosis, bacillary peliosis, and verruga peruana. The results of this study show that Bartonella bacilliformis, the agent of Oroya fever and ve
American Society for Microbiology.
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7. Mitogenicity of formalinized toxoids of staphylococcal enterotoxin B.
Staphylococcal enterotoxin B is a potent mitogen for mouse and human lymphocytes. Mitogenic activity was retained after detoxification of the enterotoxin by formaldehyde at pH 5.0, 7.5, OR 9.5. The most active toxoid (pH 7.5) was separated into a monomeric, a dimeric, and a polymeric fraction (1 x 10(5) to 3 x 10(5) molecular weight) by gel filtration, and a
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8. Mitogenicity of the Recombinant Mycobacterial 27-Kilodalton Lipoprotein Is Not Connected to Its Antiprotective Effect
We reported previously that even though immunization with the recombinant mycobacterial 27-kDa lipoprotein (r27) induced a Th1-type response in mice, the vaccinated mice became more susceptible to challenge with Mycobacterium tuberculosis. In this study we show that r27 stimulates naive splenocytes to proliferate. Acylation of r27 was crucial for this effect
American Society for Microbiology.
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9. Erythropoietin receptor (EpoR)-dependent mitogenicity of spleen focus-forming virus correlates with viral pathogenicity and processing of env protein but not with formation of gp52-EpoR complexes in the endoplasmic reticulum.
Recent evidence suggests that interactions between spleen focus-forming virus (SFFV) env products and the erythropoietin receptor (EpoR) are responsible for viral pathogenicity. Infection of factor-dependent cell lines expressing epoR (the cloned gene for EpoR) with SFFVP is mitogenic, generating cell lines that are no longer dependent on added growth factor
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10. Free hydroxyl groups are not required for endotoxic activity of lipid A.
Previous studies demonstrated that lipid A from Salmonella abortusequi loses its B-cell mitogenicity for murine spleen cells as a result of the introduction of succinyl residues on hydroxyl groups and that the inactivated lipid A specifically antagonizes the mitogenicity of endotoxin. Hypothesizing that the hydroxyl groups are essential both for its biologic
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11. Species-dependent response to streptococcal lymphocyte mitogens in rabbits, guinea pigs, and mice.
Extracellular mitogen preparations from NY5 and S84 strains of streptococci induced different responses among rabbit, guinea pig, and mouse lymphocytes. Evidence of T-cell mitogenicity is presented.
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12. Nonspecific T-lymphocyte mitogenesis by pyrogenic exotoxins from group A streptococci and Staphylococcus aureus.
Group A streptococcal pyrogenic exotoxins types A, B, and C and staphylococcal pyrogenic exotoxin were shown to be potent nonspecific T-lymphocyte mitogens. Adherent cell populations did not significantly affect the nonspecific mitogenicity.