Mmp 1 Il 1 B
Mostrando 1-12 de 37 artigos, teses e dissertações.
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1. Molecular signature of immunological mechanism behind impaired endometrial receptivity in polycystic ovarian syndrome
ABSTRACT Objective: Despite the treatment of anovulation, infertility is still one of the main complications in PCOS women during reproductive age, which appears to be mainly due to impaired uterine receptivity. This study investigated the transcriptome profiles of endometrium in PCOS patients and healthy fertile individuals as the control group. Material
Archives of Endocrinology and Metabolism. Publicado em: 2022
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2. Comparison of the effects of corneal and lacrimal gland denervation on the lacrimal functional unit of rats
RESUMO Objetivo: O nosso objetivo neste estudo foi comparar as alterações na unidade funcional lacrimal em dois modelos de síndrome do olho seco neurogênica: desnervação sensorial da córnea versus desnervação autonômica da glândula lacrimal. Métodos: A rede neural é um importante suporte para a unidade funcional lacrimal. Pode ser dividido em
Arquivos Brasileiros de Oftalmologia. Publicado em: 2022
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3. In Vitro Homeostasis of Rat Oral Epithelial Cell Cultures Following Withdrawal of Periodontal Pathogens
Resumo A inflamação dos tecidos periodontais é a consequência da interação entre patógenos periodontais e o sistema imunológico. Isso está associado ao aumento da expressão de citocinas inflamatórias, que podem exercer efeito destrutivo nos tecidos periodontais quando liberadas por um longo período. O objetivo deste estudo foi rastrear cronologic
Braz. Dent. J.. Publicado em: 2020-04
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4. Concentração de metaloprotease-2 e de interleucina-1 β no humor aquoso de cães com olhos normais e cataratosos
RESUMO: Objetivou-se determinar as concentrações da metalloprotease-2 (MMP-2) e de interleucina-1 β (IL-1 β) em cães com olhos saudáveis (n=8) e naqueles com catarata madura (n=8) e hipermatura (n=8). Correlações entre ambas as citocinas, entre as citocinas e a pressão intraocular (PIO), assim como entre as citocinas e a idade dos pacientes dentro d
Pesq. Vet. Bras.. Publicado em: 2020-03
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5. Gliclazide reduced oxidative stress, inflammation, and bone loss in an experimental periodontal disease model
Abstract Objective The aim of this study was to evaluate the effects of gliclazide on oxidative stress, inflammation, and bone loss in an experimental periodontal disease model. Material and Methods Male albino Wistar rats were divided into no ligature, ligature, and ligature with 1, 5, and 10 mg/kg gliclazide groups. Maxillae were fixed and scanned usin
J. Appl. Oral Sci.. Publicado em: 21/02/2019
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6. Etanercept protects rat cardiomyocytes against hypertrophy by regulating inflammatory cytokines secretion and cell apoptosis
We aimed to investigate the effect of etanercept, a tumor necrosis factor-α (TNF-α) inhibitor, on rat cardiomyocyte hypertrophy and its underlying mechanism. Primary neonatal rat cardiomyocytes were isolated from Sprague-Dawley rats. The model of rat cardiomyocyte hypertrophy was induced by endothelin, and then treated with different concentrations of etan
Braz J Med Biol Res. Publicado em: 15/05/2017
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7. Naringenin regulates production of matrix metalloproteinases in the knee-joint and primary cultured articular chondrocytes and alleviates pain in rat osteoarthritis model
Inflammation of cartilage is a primary symptom for knee-joint osteoarthritis. Matrix metalloproteinases (MMPs) are known to play an important role in the articular cartilage destruction related to osteoarthritis. Naringenin is a plant-derived flavonoid known for its anti-inflammatory properties. We studied the effect of naringenin on the transcriptional expr
Braz J Med Biol Res. Publicado em: 23/03/2017
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8. Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model
Liver fibrosis occurring as an outcome of non-alcoholic steatohepatitis (NASH) can precede the development of cirrhosis. We investigated the effects of sorafenib in preventing liver fibrosis in a rodent model of NASH. Adult Sprague-Dawley rats were fed a choline-deficient high-fat diet and exposed to diethylnitrosamine for 6 weeks. The NASH group (n=10) rece
Braz J Med Biol Res. Publicado em: 24/02/2015
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9. Effects of bromopride on expression of metalloproteinases and interleukins in left colonic anastomoses: an experimental study
Anastomotic dehiscence is the most severe complication of colorectal surgery. Metalloproteinases (MMPs) and interleukins (ILs) can be used to analyze the healing process of anastomosis. To evaluate the effects of bromopride on MMP and cytokine gene expression in left colonic anastomoses in rats with or without induced abdominal sepsis, 80 rats were divided i
Braz J Med Biol Res. Publicado em: 15/08/2014
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10. SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway
Chronic inflammation induced by amyloid-beta (Aβ) plays a key role in the development of age-related macular degeneration (AMD), and matrix metalloproteinase-9 (MMP-9), interleukin (IL)-6, and IL-8 may be associated with chronic inflammation in AMD. Sirtuin 1 (SIRT1) regulates inflammation via inhibition of nuclear factor-kappa B (NF-κB) signaling, and res
Braz J Med Biol Res. Publicado em: 2013-08
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11. Ethyl-pyruvate reduces lung injury matrix metalloproteinases and cytokines and improves survival in experimental model of severe acute pancreatitis
PURPOSE: To investigate if the ethyl-pyruvate solution could reduce mortality in AP and/or diminish the acute lung injury. METHODS: Forty male rats, weighing between 270 to 330 grams were operated. An experimental model of severe AP by injection of 0.1ml/100g of 2.5% sodium taurocholate into the bilio-pancreatic duct was utilized. The rats were divided into
Acta Cir. Bras.. Publicado em: 2013-08
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12. Tratamento com inibidor da Rho quinase em cobais com inflamação pulmonar alérgica crônica: modulação da inflamação eosinofílica, da expressão de citocinas inflamatórias, da matriz extracelular e do estresse oxidativo no parênquima pulmonar / Treatment with Rho-kinase inhibitor in guinea pigs with chronic allergic inflammation: modulation of eosinophilic inflammation, expression of inflammatory cytokines, extracellular matrix and oxidative stress in lung tissue
RATIONALE: Previous studies with Rho-kinase inhibitors suggest a beneficial influence of these drugs in asthma. The relevance of distal lung tissue in functional asthmatic impairment has been intensely emphasized. There have not been any previous studies evaluating the effects of these inhibitors on the modulation of distal lung mechanics and histopathologic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/12/2012