Molecular Entities
Mostrando 1-12 de 71 artigos, teses e dissertações.
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1. Relationship between Electrochemical Parameters, Cytotoxicity Data against Cancer Cells of 3-Thio-Substituted Nor-Beta-Lapachone Derivatives. Implications for Cancer Therapy
Electrochemical methods are powerful in the characterization and design of redox-modulating agents. We, herein, report the electrochemical investigation, in aprotic medium, of eleven synthetic 3-thio-substituted-nor-beta-lapachones, along with the determination of cytotoxic activity and correspondent selectivity index, against several cancer cell lines and o
J. Braz. Chem. Soc.. Publicado em: 2019-03
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2. The role of condensed tannins in ruminant animal production: advances, limitations and future directions
ABSTRACT Tannins represent one of the most abundant polyphenolic compounds in plants. Tannins exist as a multitude of chemically unique entities in nature. The most commonly occurring tannins are typically divided into two major classes based on chemical structure: hydrolysable (HT) or condensed tannins (CT). Hydrolysable tannins are esters of gallic or ella
R. Bras. Zootec.. Publicado em: 2017-12
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3. Urological cancer related to familial syndromes
ABSTRACT Cancer related to hereditary syndromes corresponds to approximately 5-10% of all tumors. Among those from the genitourinary system, many tumors had been identified to be related to genetic syndromes in the last years with the advent of new molecular genetic tests. New entities were described or better characterized, especially in kidney cancer such
Int. braz j urol.. Publicado em: 2017-04
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4. Molecular analysis of phylogeographic subspecies in three Ponto-Caspian sturgeon species
Sturgeons (Order Acipenseriformes) represent an extremely valuable natural resource that is now facing depletion. In the current study we evaluate if the traditional classification in subspecies of Acipenser gueldenstaedtii, Acipenser stellatus and Huso huso, endemic to Ponto-Caspian region is sustained by molecular analysis and if these represent Evolutiona
Genet. Mol. Biol.. Publicado em: 2014-09
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5. Industry withdrawal from psychiatric medication development
Between 1950 and 1969, on a serendipitous basis, psychiatric drug development flourished. However, there has been a steep decline in the development of new medication classes. Instead of new molecular entities, slight molecular modifications producing “me-too” drugs attempted to garner market share. With failing profitability, industry is now withdrawing
Rev. Bras. Psiquiatr.. Publicado em: 02/06/2014
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6. Philadelphia-negative chronic myeloproliferative neoplasms
Chronic myeloproliferative diseases without the Philadelphia chromosome marker (Ph-), although first described 60 years ago, only became the subject of interest after the turn of the millennium. In 2001, the World Health Organization (WHO) defined the classification of this group of diseases and in 2008 they were renamed myeloproliferative neoplasms based on
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2012
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7. Tipos especiais histológicos de carcinomas da mama : perfil imunoistoquímico com ênfase na classificação molecular / Histological special types of breast carcinomas : immunohistochemical profile with emphasis on molecular classification
Most invasive breast carcinomas are classified as invasive ductal carcinoma, not otherwise specified (IDC-NOS), while approximately 25% are defined as special histological types (HST). These HST of breast carcinomas are categorized into at least 17 distinct pathological entities. Most studies in the literature regarding the molecular classification (luminal
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/12/2011
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8. Pharmacokinetic Properties In Silico Modeling for New Chemical Entities Evaluation. / Modelagem In silico de propriedades farmacocinéticas para a avaliação de candidatos a novos fármacos
The pharmacokinetic (PK) processes of absorption, distribution, metabolism and excretion (ADME), have been identified as one of the major causes of new chemical entities (NCEs) failure in early clinical trials. In silico models are receiving increased attention in recent years from the pharmaceutical industry, which is integrating a paradigm of multiple phar
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/08/2011
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9. Genetic diversity and population structure of Brazilian native bovine breeds.
Conservation and improvement strategies should be based on the association between genetic and phenotypic characteristics. The objective of this work was to characterize five native Brazilian cattle breeds (Caracu, Crioulo Lageano, Curraleiro, National Polled and Pantaneiro) and two commercial breeds (Holstein and Nellore) using RAPD technique to estimate ge
Pesquisa Agropecuária Brasileira. Publicado em: 2011
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10. Novel targeted agents for the treatment of bladder cancer: translating laboratory advances into clinical application
Bladder cancer is a common and frequently lethal cancer. Natural history studies indicate two distinct clinical and molecular entities corresponding to invasive and non-muscle invasive disease. The high frequency of recurrence of noninvasive bladder cancer and poor survival rate of invasive bladder cancer emphasizes the need for novel therapeutic approaches.
International braz j urol. Publicado em: 2010-06
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11. The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases- a review
Publicado em: 2010
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12. Avaliação da Associação Molecular de Complexos Metálicos com Ligante Triazenido 1-óxido / Evaluation of the Association of Molecular Complexes Metallics with Binding Triazenide 1-oxide
In this dissertation were synthetized six compounds, of the which one is free ligand 1- phenyl-3-(4-nitrophenyl) triazene 1-oxide (1) and five are triazenido complexes of [Ni(O2NC6H4NNN(O)C6H5)2(C5H5N)2] (2), [Zn(O2NC6H4NNN(O)C6H5)2(C5H5N)2] (3), [Ag(O2NC6H4NNN(O)C6H4)(PPh3)2] (4), [V(O)2(O2NC6H4NNN(O)C6H4)(C5H5N)] (5) e [Pb(O2NC6H4NNN(O)C6H5)2] (6). The com
Publicado em: 2008