Molecular Platform
Mostrando 1-12 de 105 artigos, teses e dissertações.
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1. Downregulation of CSF-derived miRNAs miR-142-3p and miR-17-5p may be associated with post-dural puncture headache in pregnant women upon spinal anesthesia
Abstract Background: Postdural puncture headache (PDPH) develops due to puncture of the dura mater. The risk factors that influence PDPH incidence are Body Mass Index (BMI), sex, spinal needle type, history of headache, and loss of Cerebrospinal fluid (CSF) volume, yet there is no consensus on these risk factors. The pathophysiology of PDPH is poorly unders
Brazilian Journal of Anesthesiology. Publicado em: 2022
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2. In silico Risk Assessment Studies of New Psychoactive Substances Derived from Amphetamines and Cathinones
The amount and variety of new psychoactive substances (NPS) are expanding, and there are difficulties in assessing their risks. In this regard, in silico methods are potentially useful to predict NPS properties faster and at a lower cost. In this work a quantitative structure-activity relationship (QSAR) model was used to verify the risk of drugs derived fro
J. Braz. Chem. Soc.. Publicado em: 2020-05
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3. COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil
ABSTRACT The accuracy of commercially available tests for COVID-19 in Brazil remains unclear. We aimed to perform a meta-analysis to describe the accuracy of available tests to detect COVID-19 in Brazil. We searched at the Brazilian Health Regulatory Agency (ANVISA) online platform to describe the pooled sensitivity (Se), specificity (Sp), diagnostic odds ra
Braz J Infect Dis. Publicado em: 2020-04
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4. Establishment and optimization of a hydroponic system for root morphological and nutritional analysis of citrus
ABSTRACT The hydroponic growth system is a convenient platform for studying whole plant physiology, especially for root morphological and nutritional analysis. However, we found that most hydroponic systems described in the literature are not suitable for citrus plants. In this study, a hydroponic system for citrus was designed, comprising three principal co
Sci. agric. (Piracicaba, Braz.). Publicado em: 04/11/2019
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5. Differential Molecular Signature of Human Saliva Using ATR-FTIR Spectroscopy for Chronic Kidney Disease Diagnosis
Resumo Os sintomas da doença renal crônica (DRC) são frequentemente inespecíficos ou ausentes nos estágios iniciais desta doença. Desta forma, existe uma demanda para o desenvolvimento de plataformas com baixo custo, não-invasivas e com alta acurácia para o diagnóstico da DRC. Nós hipotetizamos que o nível dos componentes salivares se alteram pela
Braz. Dent. J.. Publicado em: 07/10/2019
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6. Um medidor de luminosidade com módulo sensor integrado e aquisição automática de dados com aplicações didáticas
Resumo Este trabalho apresenta o projeto de um medidor de luz para atividades didáticas experimentais utilizando o sensor de luz integrado BH1750. O medidor de luz é construído conectando o sensor BH1750 com a plataforma Arduino. Os dados são transferidos para um computador e são visualizados durante a execução de um experimento por meio de tabelas e
Rev. Bras. Ensino Fís.. Publicado em: 14/02/2019
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7. Improving the reference standard for the diagnosis of canine visceral leishmaniasis: a challenge for current and future tests
BACKGROUND Studies aimed at validating canine visceral leishmaniasis diagnostic tests present heterogeneous results regarding test accuracy, partly due to divergences in reference standards used and different infection evolution periods in animals. OBJECTIVE This study aimed to evaluate the accuracy of the rapid test-dual path platform (TR-DPP) (Biomangu
Mem. Inst. Oswaldo Cruz. Publicado em: 31/01/2019
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8. An alternative storage method for characterization of the intestinal microbiota through next generation sequencing
ABSTRACT Gut microbiota has been the subject of various molecular studies mainly due to its importance and wide-ranging relationships with human hosts. However, the storage of fecal samples prior to DNA extraction is critical when characterizing the composition of intestinal microbiota. Therefore, we aimed to understand the effects of different fecal storage
Rev. Inst. Med. trop. S. Paulo. Publicado em: 29/11/2018
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9. Molecular farming of antimicrobial peptides: available platforms and strategies for improving protein biosynthesis using modified virus vectors
Abstract The constant demand for new antibiotic drugs has driven efforts by the scientific community to prospect for peptides with a broad spectrum of action. In this context, antimicrobial peptides (AMPs) have acquired great scientific importance in recent years due to their ability to possess antimicrobial and immunomodulatory activity. In the last two dec
An. Acad. Bras. Ciênc.. Publicado em: 18/10/2018
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10. Mathematical modeling of the batch adsorption of proteins on new restricted access media with poly(ethylene glycol) as a semi-permeable barrier using compact finite differences
Abstract In this work we describe a mathematical analysis of the batch adsorption process of several proteins using a new restricted access medium consisting of agarose beads grafted with poly(ethylene glycol) (PEG) as a semi-permeable barrier and immobilized metal ions or ion exchange groups as binding sites. The model was fitted to experimental data, allow
Braz. J. Chem. Eng.. Publicado em: 2018-01
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11. The complete mitochondrial genome of Engyodontium album and comparative analyses with Ascomycota mitogenomes
Abstract Engyodontium album is a widespread pathogen that causes different kinds of dermatoses and respiratory tract diseases in humans and animals. In spite of its perniciousness, the basic genetic and molecular background of this species remains poorly understood. In this study, the mitochondrial genome sequence of E. album was determined using a high-thro
Genet. Mol. Biol.. Publicado em: 23/10/2017
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12. Protein-species quantitative venomics: looking through a crystal ball
Abstract In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level of the protein species present in the venom, and the absolute quantification of the venom proteins (the term “protein species” is used he
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 06/07/2017