Monocyte Chemoattractant Proteins
Mostrando 1-12 de 23 artigos, teses e dissertações.
-
1. As células linhagem negativa (Lin) de medula óssea atenuam a progressão da doença renal crônica / Lineage negative bone marrow cells attenuate the progression of chronic renal failure
Progressive renal failure continues to be a challenge. The use of bone marrowderived stem cells (SCs) represents a means of meeting that challenge. We used lineage-negative (Lin-) SCs to test the hypothesis that Lin- cell infusion decreases renal injury. Syngeneic Fischer 344 rats were submitted to 5/6 nephrectomy and divided into 3 groups: Nx (untreated); N
Publicado em: 2008
-
2. Estudo da inibição do oxido nitrico sobre funções de eosinofilos humanos estimulados com eotaxina e RANTES in vitro / Study of nitric oxide inhibition in human eosinophil functions stimulated in vitro with eotaxin and RANTES
Eosinophils participate in the pathogenesis of many inflammatory diseases, including parasitic infections and allergic diseases. Of the allergic diseases, asthma is characterized by eosinophilia. Currently, asthma affects 300 million people in world, and is an important public health problem. Asthma is an inflammatory chronic disease that involves interactio
Publicado em: 2008
-
3. Influência do polimorfismo do gene do MCP-1 e do seu receptor CCR2 em parâmetros clínicos e excreção urinária do MCP-1 em pacientes com nefrite lúpica / Influence of MCP-1 gene polymorphism and its receptor CCR2 polymorphism in clinical parameters and urinary excretion of MCP-1 with lupus nephritis patients
Introdução: A nefrite lúpica (NL) é o maior preditor de morbidade e mortalidade em pacientes portadores de lupus eritematoso sistêmico. Recentes estudos mostram que a proteína quimiotática de monócitos (MCP-1) está implicada na ativação de células inflamatórias, afetando a progressão e a severidade da NL, e que a excreção urinária do MCP-1 (
Publicado em: 2008
-
4. Quantification of bovine cytokine gene expression using real-time RT-PCR methodology
T cells produce cytokines that affect host response to infection. This paper reports real-time RT-PCR conditions and validation steps for accurate quantification of Bos indicus cytokines, interleukin (IL)-2, IL-4, IL-8, IL12p-35, IL-13, tumoral necrosis factor (TNF)-alpha, interferon (IFN)-gamma, monocyte chemoattractant proteins (MCP)-1 and MCP-2, and the g
Genetics and Molecular Biology. Publicado em: 2007
-
5. Induction of selective biological responses to chemoattractants in a human monocyte-like cell line.
The availability of monocyte cell lines that can be induced to differentiate in a predictable fashion can provide important tools for the study of the biochemical mechanisms of specific cellular responses. The U937 human monocyte cell line was previously shown to differentiate into chemotactically responsive cells when incubated with supernatants of lectin-s
-
6. C/EBP-related protein 2 confers lipopolysaccharide-inducible expression of interleukin 6 and monocyte chemoattractant protein 1 to a lymphoblastic cell line.
C/EBP-related proteins 2 and 3 (CRP2 and CRP3) are differentially expressed by P388 lymphoblasts and their derivative P388D1(IL1) macrophages. We have ectopically expressed CRP2, the predominant CRP in macrophages, in P388 lymphoblasts. The expression of CRP2 is sufficient to confer the lipopolysaccharide (LPS)-inducible expression of interleukin 6 and monoc
-
7. Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses.
Individuals with cancer have previously been shown to have abnormal chemotactic responsiveness. Surgical removal of the tumor often resulted in normalization of monocyte function, which suggests that human neoplasms might inhibit monocyte chemotaxis by release of soluble mediators. We therefore examined the effects of cancerous effusions on monocyte polariza
-
8. Mycoplasmal Lipopeptide MALP-2 Induces the Chemoattractant Proteins Macrophage Inflammatory Protein 1α (MIP-1α), Monocyte Chemoattractant Protein 1, and MIP-2 and Promotes Leukocyte Infiltration in Mice
Natural as well as experimental infections with pathogenic mycoplasmas lead to cellular responses characterized by early polymorphonuclear leukocyte influx, which in turn is followed by infiltration of macrophages. Since some of the most potent leukocyte chemoattractants are macrophage products, we investigated whether the 2-kDa macrophage-activating lipopep
American Society for Microbiology.
-
9. Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface.
Monocytes were stimulated to increase their cell surface quantity of leukocyte adhesion proteins p150,95 and Mac-1 by the chemoattractant formyl-methionyl-leucyl-phenylalanine, or other mediators such as platelet-derived growth factor, tumor necrosis factor, C5a, and leukotriene B4. Dose-response curves indicated variations in the sensitivity of monocytes an
-
10. The human homolog of the JE gene encodes a monocyte secretory protein.
The mouse fibroblast gene, JE, was one of the first platelet-derived growth factor-inducible genes to be described as such. The protein encoded by JE (mJE) is the prototype of a large family of secreted, cytokinelike glycoproteins, all of whose members are induced by a mitogenic or activation signal in monocytes macrophages, and T lymphocytes; JE is the only
-
11. MIP-1alpha as a critical macrophage chemoattractant in murine wound repair.
At sites of injury, macrophages secrete growth factors and proteins that promote tissue repair. While this central role of the macrophage has been well studied, the specific stimuli that recruit macrophages into sites of injury are not well understood. This study examines the role of macrophage inflammatory protein 1alpha (MIP-1alpha), a C-C chemokine with m
-
12. Molecular determinants for CC-chemokine recognition by a poxvirus CC-chemokine inhibitor
Poxviruses express a family of secreted proteins that bind with high affinity to chemokines and antagonize the interaction with their cognate G protein-coupled receptors (GPCRs). These viral inhibitors are novel in structure and, unlike cellular chemokine receptors, are able to specifically interact with most, if not all, CC-chemokines. We therefore sought t
The National Academy of Sciences.