Mucosal Immunization
Mostrando 1-12 de 384 artigos, teses e dissertações.
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1. Molecular adjuvant interleukin-33 enhances the antifertility effect of Lagurus lagurus zona pellucida 3 DNA vaccine administered by the mucosal route
It has been shown that cytokines can act as molecular adjuvant to enhance the immune response induced by DNA vaccines, but it is unknown whether interleukin 33 (IL-33) can enhance the immunocontraceptive effect induced by DNA vaccines. In the present study, we explored the effects of murine IL-33 on infertility induced by Lagurus lagurus zona pellucida 3 (Lz
Braz J Med Biol Res. Publicado em: 10/12/2013
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2. The adjuvant effect of the mesoporous nanostructurated SBA-15 silica in immunizations by the oral route. / Efeito adjuvante da sílica mesoporosa nanoestruturada SBA-15 na imunização pela via oral.
The nanostructured SBA-15 silica is a polymer that due to its physicochemical properties shows great potential as a mucosal adjuvant. Immunization by the oral route of mice with Hepatitis A vaccine or human gama globulin adsorbed/encapsulated in SBA-15 revealed increases in the IgG e IgA specific antibody titers and showed that this silica does not interfere
Publicado em: 2009
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3. Avaliação das propriedades imunomoduladoras de toxinas termo-lábeis do tipo II produzidas por Escherichia coli enterotoxigênica (ETEC) administradas por via transcutânea. / Evaluation of the immunomodulatory properties of type II heat-labile toxins produced by enterotoxigenic Escherichia coli (ETEC) administered by transcutaneous route.
Heat-labile toxins expressed by enterotoxigenic Escherichia coli (LT-I, LT-IIa and LT-IIb) are potent systemic and mucosal adjuvants. These proteins have low identity (<14%) in their B subunits and bind to different receptors, which may result in differential biological properties. The objective of this work was to evaluate the immune response induced by LT-
Publicado em: 2009
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4. Nasal immunization with outer membrane antigens of Neisseria meningitidis B selected for the highest expression of the immunotype of LPS 3,7,9 with monoclonal antibodies and Bordetella pertussis as adjuvants in neonates mice. / Imunização nasal com antígenos de membrana externa de Neisseria meningitidis B selecionados para a maior expressão do imunotipo de LPS 3, 7, 9 com anticorpos monoclonais e Bordetella pertussis como adjuvante em camundongos neonatos.
The natural habitat of Neisseria meningitidis is the human nasopharynx, and the bacterium is transmitted by direct mouth-to-mouth contact or by the inhalation of released mucous particles during close contact. N meningitidis is a Gram-negative bacterium responsible for significant mortality worldwide. While effective polysaccharide-based vaccines exist again
Publicado em: 2008
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5. Adjuvant requirement for successful immunization with recombinant derivatives of Plasmodium vivax merozoite surface protein-1 delivered via the intranasal route
Recently, we generated two bacterial recombinant proteins expressing 89 amino acids of the C-terminal domain of the Plasmodium vivax merozoite surface protein-1 and the hexa-histidine tag (His6MSP1(19)). One of these recombinant proteins contained also the amino acid sequence of the universal pan allelic T-cell epitope (His6MSP1(19)-PADRE). In the present st
Memórias do Instituto Oswaldo Cruz. Publicado em: 10/05/2007
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6. Aplicação de linhagens geneticamente modificadas de Bacillus subtilis no desenvolvimento de vacinas de mucosas contra patógenos entéricos. / Genetically modified Bacillus subtilis strains applied in the development of mucosal vaccines against enteric pathogens.
Bacillus subtilis é uma bactéria gram positiva de solo, não patogênica, não colonizadora de tecidos, naturalmente transformável e formadora de esporos utilizada como modelo de estudo de bactérias gram-positivas. Essas características acarretam em vantagens para a produção de proteases de interesse industrial e para utilização como veículo de ant
Publicado em: 2007
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7. IgA response in serum and gut secretion in sensitized mice fed with the dust mite Dermatophagoides pteronyssinus extract
Induced oral tolerance to mucosal-exposed antigens in immunized animals is of particular interest for the development of immunotherapeutic approaches to human allergic diseases. This is a unique feature of mucosal surfaces which represent the main contact interface with the external environment. However, the influence of oral tolerance on specific and natura
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-06
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8. Characterization of the mucosal and systemic immune response induced by Cry1Ac protein from Bacillus thuringiensis HD 73 in mice
The present paper describes important features of the immune response induced by the Cry1Ac protein from Bacillus thuringiensis in mice. The kinetics of induction of serum and mucosal antibodies showed an immediate production of anti-Cry1Ac IgM and IgG antibodies in serum after the first immunization with the protoxin by either the intraperitoneal or intraga
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-02
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9. Mucosal vaccination overcomes the barrier to recombinant vaccinia immunization caused by preexisting poxvirus immunity
Overcoming preexisting immunity to vaccinia virus in the adult population is a key requirement for development of otherwise potent recombinant vaccinia vaccines. Based on our observation that s.c. immunization with vaccinia induces cellular and antibody immunity to vaccinia only in systemic lymphoid tissue and not in mucosal sites, we hypothesized that the m
The National Academy of Sciences.
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10. Human Immunodeficiency Virus Type 1 Gag-Specific Mucosal Immunity after Oral Immunization with Papillomavirus Pseudoviruses Encoding Gag
Mucosal surfaces are the primary portals for human immunodeficiency virus (HIV) transmission. Because systemic immunization, in general, does not induce effective mucosal immune responses, a mucosal HIV vaccine is urgently needed. For this study, we developed papillomavirus pseudoviruses that express HIV-1 Gag. The pseudoviruses are synthetic, nonreplicating
American Society for Microbiology.
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11. Urease-Based Mucosal Immunization against Helicobacter heilmannii Infection Induces Corpus Atrophy in Mice
Mucosal immunization with Helicobacter heilmannii urease B or Helicobacter pylori urease, given nasally with cholera toxin, protects BALB/c mice against H. heilmannii infection and significantly reduces a preexisting infection. However, immunization aggravates gastric corpus atrophy. Our results underline the necessity of defining immunization regimens that
American Society for Microbiology.
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12. Induction of optimal mucosal antibody responses: effects of age, immunization route(s), and dosing schedule in rats.
The antitoxin response in intestinal mucosa was studied in rats immunized either intestinally or by combined parenteral and intestinal dosing with cholera toxin or cholera toxoid. Attention was given to the duration of enteric priming and the magnitude and time course of mucosal anti-cholera toxin responses in rats of defined age. Cholera toxin given only in