Multiepitope Gene
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Expressão de antígeno multiepítopo do Dengue virus em planta utilizando vetor de PVX
Nos últimos anos as infeções pelo Dengue virus (DENV) têm emergido como um grande problema de saúde pública, com expansão da distribui-lo geográfica e aumento da atividade epidêmica em regiões tropicais e subtropicais da Ásia, África, Américas Central e do Sul. O diagnóstico da dengue tem sido realizado principalmente.por técnicas sorológicas
Publicado em: 2009
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2. Expressão e purificação de uma proteína multiepítopo recombinante desenhada a partir de proteínas do vírus da hepatite C
Hepatitis C is considered one of the largest problems of public health in the world, inclusively in Brazil, whereas a preventive vaccine none is available; the number of asymptomatic infections is elevated and for control of the disease, there exist only imported kits. Considering, principally, the increase of preoccupation with the detection of precocious h
Publicado em: 2007
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3. Anaplasma marginale : análise da variabilidade do gene msp1 a e avaliação imunogênica da vacina de DNA contendo genes para MSP1a, MSP1b e MSP5 em camundongos BALB/c
Anaplasma marginale is an important tick-transmitted rickettsial pathogen of cattle that invades and multiplies within erythrocytes, causing severe hemolytic anemia during acute infection. Immunization with purified outer membrane proteins (OMP) induces protection against acute A. marginale disease. Of 21 OMP described six major surface proteins (MSPs 1a, 1b
Publicado em: 2007
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4. Multiantigen/multiepitope–directed immune-specific suppression of “complex autoimmune encephalomyelitis” by a novel protein product of a synthetic gene
Systemic administration of antigen/peptide for peripheral T cell tolerance has long been investigated as a potential approach to therapy of autoimmune diseases. The multiple antimyelin T cell reactivities likely to be associated with multiple sclerosis (MS) impose major difficulties in devising such an immune-specific therapeutic approach to the disease, bec
American Society for Clinical Investigation.
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5. CD8+ Lymphocytes from Simian Immunodeficiency Virus-Infected Rhesus Macaques Recognize 14 Different Epitopes Bound by the Major Histocompatibility Complex Class I Molecule Mamu-A*01: Implications for Vaccine Design and Testing
It is becoming increasingly clear that any human immunodeficiency virus (HIV) vaccine should induce a strong CD8+ response. Additional desirable elements are multispecificity and a focus on conserved epitopes. The use of multiple conserved epitopes arranged in an artificial gene (or EpiGene) is a potential means to achieve these goals. To test this concept i
American Society for Microbiology.
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6. Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen
DNA and modified vaccinia virus Ankara (MVA) are vaccine vehicles suitable and safe for use in humans. Here, by using a multicytotoxic T-lymphocyte (CTL) epitope gene and a DNA prime-MVA boost vaccination regimen, high levels of CTLs specific for a single simian immunodeficiency virus (SIV) gag-derived epitope were elicited in rhesus macaques. These vaccine-
American Society for Microbiology.