Mutagens
Mostrando 1-12 de 265 artigos, teses e dissertações.
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1. To be or not to be a carcinogen; delving into the glyphosate classification controversy
The International Agency for Research on Cancer (IARC) placed the most widely used herbicide glyphosate (GLY) into the category 2A (probably carcinogenic to humans), a classification questioned by experts from academia and industry. This article critically appraised the epidemiological and experimental data that led the IARC working group (WG) to consider GL
Braz. J. Pharm. Sci.. Publicado em: 15/07/2019
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2. Improving Production of Tacrolimus In Streptomyces Tacrolimicus (ATCC 55098) Through Development of Novel Mutant by Dual Mutagenesis
ABSTRACT Tacrolimus is a polyketide macrolide produced by Streptomyces species which is widely used as anti-fibrotic agent and potent immunosuppressant. In this article dual mutagenesis approach using mutagens (NTG+EMS+UV) was used to develop a mutant strain of Streptomyces tacrolimicus (ATCC 55098) for higher tacrolimus production and this strain showed hig
Braz. arch. biol. technol.. Publicado em: 17/08/2017
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3. Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow
ABSTRACT The aim of this study was to evaluate the possible protective of C. guianensis oil against MMC and CP, which are direct- and indirect-acting chemical mutagens, using the micronucleus test. Three experiments were performed. First the C. guianensis oil was co-administered to mice at doses of 250, 500 and 1000 mg/kg bw with 4 mg/kg bw MMC or 50 mg/kg b
An. Acad. Bras. Ciênc.. Publicado em: 29/06/2017
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4. Isolation and characterization of flavanols from Anthocephalus cadamba and evaluation of their antioxidant, antigenotoxic, cytotoxic and COX-2 inhibitory activities
ABSTRACT In search of lead molecules for use in disease prevention and as food additive from natural sources, two flavanols were isolated from leaves of Anthocephalus cadamba (Roxb.) Miq., Rubiaceae. Their structures were established as 6-hydroxycoumarin-(4"→8)-(-)-epicatechin and 6-hydroxycoumarin-(4"→8)-(-)-epicatechin-(4→6‴)-(-)-epicatechin on the
Rev. bras. farmacogn.. Publicado em: 2016-08
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5. The improvement of competitive saprophytic capabilities of Trichoderma species through the use of chemical mutagens
Abstract The antagonistic potential of Trichoderma strains was assayed by studying the effect of their culture filtrate on the radial growth of Sclerotium rolfsii, the causal agent of chickpea collar rot. Trichoderma harzianum-1432 (42.2%) and Trichoderma atroviride (40.3%) were found to be strong antagonists. To enhance their antagonistic potential, mutagen
Braz. J. Microbiol.. Publicado em: 2016-03
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6. Enhanced alkaline cellulases production by the thermohalophilic Aspergillus terreus AUMC 10138 mutated by physical and chemical mutagens using corn stover as substrate
Abstract A thermohalophilic fungus, Aspergillus terreus AUMC 10138, isolated from the Wadi El-Natrun soda lakes in northern Egypt was exposed successively to gamma and UV-radiation (physical mutagens) and ethyl methan-sulfonate (EMS; chemical mutagen) to enhance alkaline cellulase production under solid state fermentation (SSF) conditions. The effects of dif
Braz. J. Microbiol.. Publicado em: 2015-12
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7. The influence of organic solvents on estimates of genotoxicity and antigenotoxicity in the SOS chromotest
In this work, the toxicity and genotoxicity of organic solvents (acetone, carbon tetrachloride, dichloromethane, dimethylsulfoxide, ethanol, ether and methanol) were studied using the SOS chromotest. The influence of these solvents on the direct genotoxicity induced by the mutagens mitomycin C (MMC) and 4-nitroquinoline-1-oxide (4-NQO) were also investigated
Genetics and Molecular Biology. Publicado em: 2012
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8. Relação do hábito alimentar e polimorfismos da MTHFR C677T com a instabilidade genômica em fumicultores gaúchos
Genetic damage can occur spontaneously under normal metabolic circumstances and can also be present in situations of dietary deficiency or inadequate intake of nutrients and excessive exposure to environmental mutagens. The purpose of this study was to evaluate the influence of the intake of micronutrients B12, B6 and folate and of polymorphism MTHFR C677T i
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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9. Atividades melanogênica, genotóxica e antiproliferativa de extratos de Brosimum gaudichaudii Trécul e Dorstenia brasiliensis Lam induzidas por radiação UVA.
As furanocumarinas lineares ou psoralenos são fotossensibilizadores empregados na dermatologia associados a ultravioleta A no tratamento de doenças como o vitiligo. A fotoquimioterapia tem reações adversas imediatas (náuseas, prurido, eritema e xerodermia) e tardias (carcinogênese e, possivelmente, catarata). No Brasil, não existe medicamento fitoter�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/11/2011
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10. AvaliaÃÃo das AlteraÃÃes HematolÃgicas, BioquÃmicas e GenotÃxicas nos Trabalhadores Expostos à AgrotÃxicos em MunicÃpios do Estado do Piauà / Evaluation of Hematologic, Biochemical and Genotoxic Effects in Workers Exposed to Pesticide in Municipalities of PiauÃ
A utilizaÃÃo de agrotÃxicos na agricultura elevou rapidamente seu consumo, especialmente de forma indiscriminada, sendo o Brasil um dos maiores mercados, representando 16% da venda mundial. No PiauÃ, a expansÃo agrÃcola na regiÃo dos cerrados contribuiu para o aumento do seu uso, expondo os agricultores a danos ao DNA. O objetivo desse estudo foi aval
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/09/2011
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11. Estudo das alteraÃÃes hematolÃgicas, bioquÃmicas e genotÃxicas induzidas por agrotÃxicos em agricultores do estado do Piauà / STUDY OF POSSIBLE GENETIC CHANGES INDUCED BY PESTICIDES IN FARMERS IN THE STATE OF PIAUÃ
Exposure to pesticides represents a potential risk to human health. In addition to poisoning, these compounds may interact with DNA, causing degenerative diseases, including cancer. The risk assessment for pesticides was conducted in the municipalities of Picos, Piripiri, Barras and Josà de Freitas with farm workers (exposed group) and 55 administrative off
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/09/2011
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12. Estimates of DNA damage by the comet assay in the direct-developing frog Eleutherodactylus johnstonei (Anura, Eleutherodactylidae)
The aim of this study was to use the Comet assay to assess genetic damage in the direct-developing frog Eleutherodactylus johnstonei. A DNA diffusion assay was used to evaluate the effectiveness of alkaline, enzymatic and alkaline/enzymatic treatments for lysing E. johnstonei blood cells and to determine the amount of DNA strand breakage associated with apop
Genetics and Molecular Biology. Publicado em: 28/10/2011